Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Physiological properties of the peritoneum in an adult peritoneal dialysis population over a three-year period

Johansson, Ann-Cathrine LU and Haraldsson, Borje (2006) In Peritoneal Dialysis International 26(4). p.482-489
Abstract
Objectives: To describe the physiological properties of the peritoneal membrane in adult patients treated with peritoneal dialysis (PD) and to analyze the effects of patient characteristics and time. Design: Observational study. Setting: Department of Nephrology at the Sahlgrenska University Hospital. Method: Peritoneal function was analyzed by the Personal Dialysis Capacity (PDC) test, based on the three-pore theory of capillary transport. The functional PDC variables are absorption, large-pore flow, and the area parameter (A(0)/Delta x), which determines the diffusion of small solutes. The ultrafiltration (UF) coefficient is determined mainly by A(0)/Delta x. Patients: All patients (n = 280) who had at least one PDC test done between... (More)
Objectives: To describe the physiological properties of the peritoneal membrane in adult patients treated with peritoneal dialysis (PD) and to analyze the effects of patient characteristics and time. Design: Observational study. Setting: Department of Nephrology at the Sahlgrenska University Hospital. Method: Peritoneal function was analyzed by the Personal Dialysis Capacity (PDC) test, based on the three-pore theory of capillary transport. The functional PDC variables are absorption, large-pore flow, and the area parameter (A(0)/Delta x), which determines the diffusion of small solutes. The ultrafiltration (UF) coefficient is determined mainly by A(0)/Delta x. Patients: All patients (n = 280) who had at least one PDC test done between September 1990 and August 1999. Results: In 249 patients examined soon after start of PD, area was 19000 (SD 7100) cm(2)/cm/1.73 m(2), large-pore flow 0.112 (SD 0.052) mL/min/1.73 m(2), and the UF coefficient 0.071 (SD 0.032) mL/minute/mmHg/1.73 m(2). Absorption was 1.54 (SD +2.64, -0.97) mL/min/1.73 m(2). Large-pore flow was greater in patients with severe comorbidity than in patients with fewer comorbid conditions. Elderly patients had a lower UF coefficient than did younger patients (p < 0.05). Repeated PDC tests were performed in 208 patients during a mean observation time of 18.4 months. There was a slight increase in the slope of the area-versus-time curve of 54 cm(2)/cm/1.73 m(2) per month (approximately 10% after 3 years, p < 0.01); all other parameters remained constant. Conclusion: Patient characteristics have an impact on peritoneal performance already at the start of dialysis. Peritoneal function can remain essentially stable during medium long-term PD. (Less)
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
peritoneal physiology, Personal Dialysis Capacity (PDC)
in
Peritoneal Dialysis International
volume
26
issue
4
pages
482 - 489
publisher
Multimed Inc.
external identifiers
  • wos:000239577000013
  • scopus:33748430828
ISSN
1718-4304
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)
id
bdbc8b80-af57-4ba2-9af6-ff0be9710690 (old id 686295)
alternative location
http://www.pdiconnect.com/cgi/content/abstract/26/4/482
date added to LUP
2016-04-01 15:58:52
date last changed
2021-09-29 04:44:08
@article{bdbc8b80-af57-4ba2-9af6-ff0be9710690,
  abstract     = {Objectives: To describe the physiological properties of the peritoneal membrane in adult patients treated with peritoneal dialysis (PD) and to analyze the effects of patient characteristics and time. Design: Observational study. Setting: Department of Nephrology at the Sahlgrenska University Hospital. Method: Peritoneal function was analyzed by the Personal Dialysis Capacity (PDC) test, based on the three-pore theory of capillary transport. The functional PDC variables are absorption, large-pore flow, and the area parameter (A(0)/Delta x), which determines the diffusion of small solutes. The ultrafiltration (UF) coefficient is determined mainly by A(0)/Delta x. Patients: All patients (n = 280) who had at least one PDC test done between September 1990 and August 1999. Results: In 249 patients examined soon after start of PD, area was 19000 (SD 7100) cm(2)/cm/1.73 m(2), large-pore flow 0.112 (SD 0.052) mL/min/1.73 m(2), and the UF coefficient 0.071 (SD 0.032) mL/minute/mmHg/1.73 m(2). Absorption was 1.54 (SD +2.64, -0.97) mL/min/1.73 m(2). Large-pore flow was greater in patients with severe comorbidity than in patients with fewer comorbid conditions. Elderly patients had a lower UF coefficient than did younger patients (p &lt; 0.05). Repeated PDC tests were performed in 208 patients during a mean observation time of 18.4 months. There was a slight increase in the slope of the area-versus-time curve of 54 cm(2)/cm/1.73 m(2) per month (approximately 10% after 3 years, p &lt; 0.01); all other parameters remained constant. Conclusion: Patient characteristics have an impact on peritoneal performance already at the start of dialysis. Peritoneal function can remain essentially stable during medium long-term PD.},
  author       = {Johansson, Ann-Cathrine and Haraldsson, Borje},
  issn         = {1718-4304},
  language     = {eng},
  number       = {4},
  pages        = {482--489},
  publisher    = {Multimed Inc.},
  series       = {Peritoneal Dialysis International},
  title        = {Physiological properties of the peritoneum in an adult peritoneal dialysis population over a three-year period},
  url          = {http://www.pdiconnect.com/cgi/content/abstract/26/4/482},
  volume       = {26},
  year         = {2006},
}