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Mercaptobenzothiazole or the mercapto-mix: which should be in the standard series?

Diepgen, TL ; Bruynzeel, DP ; Andersen, KE ; Brandao, FM ; Bruze, Magnus LU ; Goncalo, M ; Goossens, A ; Lahti, A ; Mahler, V and Menne, T , et al. (2006) In Contact Dermatitis 55(1). p.36-38
Abstract
Mercaptobenzothiazole (MBT) compounds are well known contact allergens. To detect rubber allergic patients we use both MBT (2% in petrolatum) and a mercapto-mix with 4 constituents of 0.5% each in our standard series. In this article the EECDRG presents data of in total 32 475 consecutive tested patients attending the respective contact dermatitis clinics from 11 centres in Europe to determine if the mix and MBT detected the same allergic patients. We found 327 patients positive to the mix or MBT, or to both. 261 were positive to the mix and 254 to MBT. MBT was negative in 73 patients who were positive to the mix. If the mix had not been in the standard series, on average 22% of patients allergic to a mercapto-compound would have been... (More)
Mercaptobenzothiazole (MBT) compounds are well known contact allergens. To detect rubber allergic patients we use both MBT (2% in petrolatum) and a mercapto-mix with 4 constituents of 0.5% each in our standard series. In this article the EECDRG presents data of in total 32 475 consecutive tested patients attending the respective contact dermatitis clinics from 11 centres in Europe to determine if the mix and MBT detected the same allergic patients. We found 327 patients positive to the mix or MBT, or to both. 261 were positive to the mix and 254 to MBT. MBT was negative in 73 patients who were positive to the mix. If the mix had not been in the standard series, on average 22% of patients allergic to a mercapto-compound would have been missed, for MBT this would have been on average 20%. All clinics would have missed a significant number of positive reactions if both compounds had not been tested. We conclude, that both the mercapto mix and MBT are required in the standard series. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
European standard series, contact dermatitis, delayed-type allergy, mercapto-mix, mercaptobenzothiazole
in
Contact Dermatitis
volume
55
issue
1
pages
36 - 38
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000238654800006
  • scopus:33745629037
ISSN
0105-1873
DOI
10.1111/j.0105-1873.2006.00864.x
language
English
LU publication?
yes
id
f4edfb14-cdd2-4d9a-890e-5532abbfd159 (old id 686533)
date added to LUP
2016-04-01 12:11:13
date last changed
2020-12-15 01:56:54
@article{f4edfb14-cdd2-4d9a-890e-5532abbfd159,
  abstract     = {Mercaptobenzothiazole (MBT) compounds are well known contact allergens. To detect rubber allergic patients we use both MBT (2% in petrolatum) and a mercapto-mix with 4 constituents of 0.5% each in our standard series. In this article the EECDRG presents data of in total 32 475 consecutive tested patients attending the respective contact dermatitis clinics from 11 centres in Europe to determine if the mix and MBT detected the same allergic patients. We found 327 patients positive to the mix or MBT, or to both. 261 were positive to the mix and 254 to MBT. MBT was negative in 73 patients who were positive to the mix. If the mix had not been in the standard series, on average 22% of patients allergic to a mercapto-compound would have been missed, for MBT this would have been on average 20%. All clinics would have missed a significant number of positive reactions if both compounds had not been tested. We conclude, that both the mercapto mix and MBT are required in the standard series.},
  author       = {Diepgen, TL and Bruynzeel, DP and Andersen, KE and Brandao, FM and Bruze, Magnus and Goncalo, M and Goossens, A and Lahti, A and Mahler, V and Menne, T and White, IR and Wilkinson, JD},
  issn         = {0105-1873},
  language     = {eng},
  number       = {1},
  pages        = {36--38},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Mercaptobenzothiazole or the mercapto-mix: which should be in the standard series?},
  url          = {http://dx.doi.org/10.1111/j.0105-1873.2006.00864.x},
  doi          = {10.1111/j.0105-1873.2006.00864.x},
  volume       = {55},
  year         = {2006},
}