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The effects of growth hormone (GH) deficiency and GH replacement on cognitive performance in adults: A meta-analysis of the current literature

Falleti, MG ; Maruff, P ; Burman, Pia LU and Harris, A (2006) In Psychoneuroendocrinology 31(6). p.681-691
Abstract
Objective: There is growing evidence in the neuropsychological literature that growth hormone (GH) deficiency is associated with cognitive impairment. There is also evidence that this impairment may be ameliorated with GH replacement therapy. The current study assessed the nature and severity of cognitive impairment associated with growth hormone deficiency, as well as effect of GH replacement on cognitive function by conducting a-meta-analysis of the published literature to date. Method: Thirteen studies met the inclusion criteria and these included: five cross-sectional studies investigating GH deficiency; and, eight (eight prospective, two of which also included cross-sectional comparisons) investigating GH replacement. Effect sizes... (More)
Objective: There is growing evidence in the neuropsychological literature that growth hormone (GH) deficiency is associated with cognitive impairment. There is also evidence that this impairment may be ameliorated with GH replacement therapy. The current study assessed the nature and severity of cognitive impairment associated with growth hormone deficiency, as well as effect of GH replacement on cognitive function by conducting a-meta-analysis of the published literature to date. Method: Thirteen studies met the inclusion criteria and these included: five cross-sectional studies investigating GH deficiency; and, eight (eight prospective, two of which also included cross-sectional comparisons) investigating GH replacement. Effect sizes (Cohen's d) fatting into six cognitive domains were computed (separately for GH deficiency and GH replacement). Results: For GH deficiency, each of the cognitive domains assessed (besides language) showed moderate to Large impairments when compared to matched controls (Effect sizes -0.46 to - 1.46). For GH replacement, even though treated patients still performed moderately to largely below that of controls, when compared to their own baselines (as in prospective analyses), moderate improvements were found in cognitive performance, particularly attention and memory. Conclusion: This meta-analysis clearly demonstrates the link between GH and cognitive performance, where poor performance can be ameliorated with GH treatment. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
meta-analysis, deficiency, growth hormone, cognition, replacement
in
Psychoneuroendocrinology
volume
31
issue
6
pages
681 - 691
publisher
Elsevier
external identifiers
  • pmid:16621325
  • wos:000238279400001
  • scopus:33646503505
ISSN
1873-3360
DOI
10.1016/j.psyneuen.2006.01.005
language
English
LU publication?
yes
id
39ec3eab-9d08-4c47-add5-4d6dd5a06071 (old id 686546)
date added to LUP
2016-04-01 12:30:02
date last changed
2020-12-08 04:00:54
@article{39ec3eab-9d08-4c47-add5-4d6dd5a06071,
  abstract     = {Objective: There is growing evidence in the neuropsychological literature that growth hormone (GH) deficiency is associated with cognitive impairment. There is also evidence that this impairment may be ameliorated with GH replacement therapy. The current study assessed the nature and severity of cognitive impairment associated with growth hormone deficiency, as well as effect of GH replacement on cognitive function by conducting a-meta-analysis of the published literature to date. Method: Thirteen studies met the inclusion criteria and these included: five cross-sectional studies investigating GH deficiency; and, eight (eight prospective, two of which also included cross-sectional comparisons) investigating GH replacement. Effect sizes (Cohen's d) fatting into six cognitive domains were computed (separately for GH deficiency and GH replacement). Results: For GH deficiency, each of the cognitive domains assessed (besides language) showed moderate to Large impairments when compared to matched controls (Effect sizes -0.46 to - 1.46). For GH replacement, even though treated patients still performed moderately to largely below that of controls, when compared to their own baselines (as in prospective analyses), moderate improvements were found in cognitive performance, particularly attention and memory. Conclusion: This meta-analysis clearly demonstrates the link between GH and cognitive performance, where poor performance can be ameliorated with GH treatment.},
  author       = {Falleti, MG and Maruff, P and Burman, Pia and Harris, A},
  issn         = {1873-3360},
  language     = {eng},
  number       = {6},
  pages        = {681--691},
  publisher    = {Elsevier},
  series       = {Psychoneuroendocrinology},
  title        = {The effects of growth hormone (GH) deficiency and GH replacement on cognitive performance in adults: A meta-analysis of the current literature},
  url          = {http://dx.doi.org/10.1016/j.psyneuen.2006.01.005},
  doi          = {10.1016/j.psyneuen.2006.01.005},
  volume       = {31},
  year         = {2006},
}