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2-deoxy-2-[F-18]fluoro-D-glucose uptake and correlation to intratumoral heterogeneity

Henriksson, Eva LU ; Kjellén, Elisabeth LU ; Wahlberg, Peter LU ; Ohlsson, Tomas G LU ; Wennerberg, Johan LU and Brun, Eva LU (2007) In Anticancer Research 27(4B). p.2155-2159
Abstract
The aim of this study was to investigate the pattern of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) uptake in relation to the intratumoral histopathological appearance. Materials and Methods: Intratumoral distribution of FDG in nude mice with xenografted tumours originating from an established head and neck squamous cell carcinoma was studied. FDG uptake and the con-elation to histopathological appearance was evaluated in four separate quarters of each tumour. Results: Variations in FDG uptake correlating to the presence of tumour cells was demonstrated. Quarters containing more than 50% tumour cells showed a significantly higher FDG uptake (p=0.028) than quarters with more stromal tissue and necrosis. Conclusion: This Study shows that the... (More)
The aim of this study was to investigate the pattern of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) uptake in relation to the intratumoral histopathological appearance. Materials and Methods: Intratumoral distribution of FDG in nude mice with xenografted tumours originating from an established head and neck squamous cell carcinoma was studied. FDG uptake and the con-elation to histopathological appearance was evaluated in four separate quarters of each tumour. Results: Variations in FDG uptake correlating to the presence of tumour cells was demonstrated. Quarters containing more than 50% tumour cells showed a significantly higher FDG uptake (p=0.028) than quarters with more stromal tissue and necrosis. Conclusion: This Study shows that the heterogenic FDG uptake within a tumour correlates to histopathological findings and that the variable appearance of tracer uptake on the PET scan depends on distribution of different tissue components in the tumour. This intratumoral heterogeneity calls for caution when evaluating a PET scan where median values of larger areas will be misguiding and thus small areas with high uptake should be regarded as the regions of interest. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
keywords
squamous cell carcinoma, 2-deoxy-2-[F-18]fluoro-D-glucose, positron emission tomography, head, and neck, intratumoral heterogeneity, xenograft
in
Anticancer Research
volume
27
issue
4B
pages
2155 - 2159
publisher
International Institute of Cancer Research
external identifiers
  • wos:000248545900006
ISSN
1791-7530
language
English
LU publication?
yes
id
fceda519-df72-4a3c-a6d6-647e35a141f0 (old id 686795)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17695498&dopt=Abstract
date added to LUP
2007-12-11 09:58:01
date last changed
2016-04-15 19:40:37
@article{fceda519-df72-4a3c-a6d6-647e35a141f0,
  abstract     = {The aim of this study was to investigate the pattern of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) uptake in relation to the intratumoral histopathological appearance. Materials and Methods: Intratumoral distribution of FDG in nude mice with xenografted tumours originating from an established head and neck squamous cell carcinoma was studied. FDG uptake and the con-elation to histopathological appearance was evaluated in four separate quarters of each tumour. Results: Variations in FDG uptake correlating to the presence of tumour cells was demonstrated. Quarters containing more than 50% tumour cells showed a significantly higher FDG uptake (p=0.028) than quarters with more stromal tissue and necrosis. Conclusion: This Study shows that the heterogenic FDG uptake within a tumour correlates to histopathological findings and that the variable appearance of tracer uptake on the PET scan depends on distribution of different tissue components in the tumour. This intratumoral heterogeneity calls for caution when evaluating a PET scan where median values of larger areas will be misguiding and thus small areas with high uptake should be regarded as the regions of interest.},
  author       = {Henriksson, Eva and Kjellén, Elisabeth and Wahlberg, Peter and Ohlsson, Tomas G and Wennerberg, Johan and Brun, Eva},
  issn         = {1791-7530},
  keyword      = {squamous cell carcinoma,2-deoxy-2-[F-18]fluoro-D-glucose,positron emission tomography,head,and neck,intratumoral heterogeneity,xenograft},
  language     = {eng},
  number       = {4B},
  pages        = {2155--2159},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer Research},
  title        = {2-deoxy-2-[F-18]fluoro-D-glucose uptake and correlation to intratumoral heterogeneity},
  volume       = {27},
  year         = {2007},
}