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Dose integration characteristics in normoxic polymer gel dosimetry investigated using sequential beam irradiation

Karlsson, Anna LU ; Gustafsson, Helen LU ; Ceberg, Sofie LU ; McAuley, K. B. and Bäck, Sven LU (2007) In Physics in Medicine and Biology 52(15). p.4697-4706
Abstract
Dose integration properties were investigated for normoxic polymer gels based on methacrylic acid (nMAG) and acrylamide/ N, N'-methylenebisacrylamide (nPAG). The effect of sequential irradiation was studied for different fractionation schemes and varying amounts of methacrylic acid for the nMAG gels. Magnetic resonance imaging (MRI) was used for read out of the absorbed dose response. The investigated gels exhibited a dependence on the fractionation scheme. The response when the total dose was divided into fractions of 0.5 Gy was compared with the response when the total dose was delivered in a single fraction. The slope of the R2 versus the absorbed dose response decreased when the absorbed dose per fraction was increased. Also, for... (More)
Dose integration properties were investigated for normoxic polymer gels based on methacrylic acid (nMAG) and acrylamide/ N, N'-methylenebisacrylamide (nPAG). The effect of sequential irradiation was studied for different fractionation schemes and varying amounts of methacrylic acid for the nMAG gels. Magnetic resonance imaging (MRI) was used for read out of the absorbed dose response. The investigated gels exhibited a dependence on the fractionation scheme. The response when the total dose was divided into fractions of 0.5 Gy was compared with the response when the total dose was delivered in a single fraction. The slope of the R2 versus the absorbed dose response decreased when the absorbed dose per fraction was increased. Also, for higher amounts of methacrylic acid in the nMAG system the difference in the response increased. For gels containing 2, 4, 6 and 8% methacrylic acid, the R2 versus the absorbed dose response increased by 35, 37, 63 and 93%, respectively. Furthermore, the effect of the fractionation was larger when a higher total absorbed dose was given. The effect was less pronounced for the investigated nPAG, containing 3% acrylamide and 3% N, N'-methylenebisacrylamide, than for the nMAG systems. Consequently, this study indicates that the nPAG system has preferable beam integration characteristics compared with the nMAG system. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Physics in Medicine and Biology
volume
52
issue
15
pages
4697 - 4706
publisher
IOP Publishing
external identifiers
  • wos:000249084000021
  • scopus:34547133466
ISSN
1361-6560
DOI
10.1088/0031-9155/52/15/021
language
English
LU publication?
yes
id
796e1a9f-8456-4152-89e0-59df2295756a (old id 687037)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17634658&dopt=Abstract
date added to LUP
2007-12-13 16:19:43
date last changed
2017-07-23 03:38:37
@article{796e1a9f-8456-4152-89e0-59df2295756a,
  abstract     = {Dose integration properties were investigated for normoxic polymer gels based on methacrylic acid (nMAG) and acrylamide/ N, N'-methylenebisacrylamide (nPAG). The effect of sequential irradiation was studied for different fractionation schemes and varying amounts of methacrylic acid for the nMAG gels. Magnetic resonance imaging (MRI) was used for read out of the absorbed dose response. The investigated gels exhibited a dependence on the fractionation scheme. The response when the total dose was divided into fractions of 0.5 Gy was compared with the response when the total dose was delivered in a single fraction. The slope of the R2 versus the absorbed dose response decreased when the absorbed dose per fraction was increased. Also, for higher amounts of methacrylic acid in the nMAG system the difference in the response increased. For gels containing 2, 4, 6 and 8% methacrylic acid, the R2 versus the absorbed dose response increased by 35, 37, 63 and 93%, respectively. Furthermore, the effect of the fractionation was larger when a higher total absorbed dose was given. The effect was less pronounced for the investigated nPAG, containing 3% acrylamide and 3% N, N'-methylenebisacrylamide, than for the nMAG systems. Consequently, this study indicates that the nPAG system has preferable beam integration characteristics compared with the nMAG system.},
  author       = {Karlsson, Anna and Gustafsson, Helen and Ceberg, Sofie and McAuley, K. B. and Bäck, Sven},
  issn         = {1361-6560},
  language     = {eng},
  number       = {15},
  pages        = {4697--4706},
  publisher    = {IOP Publishing},
  series       = {Physics in Medicine and Biology},
  title        = {Dose integration characteristics in normoxic polymer gel dosimetry investigated using sequential beam irradiation},
  url          = {http://dx.doi.org/10.1088/0031-9155/52/15/021},
  volume       = {52},
  year         = {2007},
}