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Low total cholesterol and low-density lipoprotein associated with aggression and hostility in recent suicide attempters

Suneson, Klara LU ; Asp, Marie LU ; Träskman-Bendz, Lil LU ; Westrin, Åsa LU ; Ambrus, Livia LU and Lindqvist, Daniel LU (2019) In Psychiatry Research 273. p.430-434
Abstract

Low cholesterol levels have been correlated with both suicidal and aggressive behavior in psychiatric patients. Few studies have investigated associations between serum lipid profiles and both aggressive state and trait. Fifty-two psychiatric medication-free inpatients were included in this study after a suicide attempt. Composite scores of “State Aggression” and “Trait Aggression” were calculated using relevant items from the Comprehensive Psychopathological Rating Scale and the Karolinska Scales of Personality. State Aggression was significantly and negatively correlated with total cholesterol (TC) and low-density lipoprotein (LDL). Trait Aggression was also significantly and negatively correlated with LDL, but not TC. There were... (More)

Low cholesterol levels have been correlated with both suicidal and aggressive behavior in psychiatric patients. Few studies have investigated associations between serum lipid profiles and both aggressive state and trait. Fifty-two psychiatric medication-free inpatients were included in this study after a suicide attempt. Composite scores of “State Aggression” and “Trait Aggression” were calculated using relevant items from the Comprehensive Psychopathological Rating Scale and the Karolinska Scales of Personality. State Aggression was significantly and negatively correlated with total cholesterol (TC) and low-density lipoprotein (LDL). Trait Aggression was also significantly and negatively correlated with LDL, but not TC. There were small but significant mediation effects of severity of anxiety symptoms on the relationship between State Aggression and TC as well as LDL. In exploratory analyses we found that low cholesterol was also associated with personality traits of hostility. Moreover, low cholesterol was more robustly associated with personality trait items related to interpersonal aggression, as opposed to items related to irritability or more indirect, non-overt aggression. Our findings suggest that low cholesterol is associated with both state and trait aggression in suicide attempters. Future mechanistic studies are warranted to better understand the relationship between low cholesterol and high aggression in suicide attempters.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biological, Lipids, Personality, Psychiatry
in
Psychiatry Research
volume
273
pages
5 pages
publisher
Elsevier
external identifiers
  • scopus:85060296708
ISSN
0165-1781
DOI
10.1016/j.psychres.2019.01.056
language
English
LU publication?
yes
id
68740756-8db3-4ae5-bbfd-47614c80e96a
date added to LUP
2019-01-31 12:56:55
date last changed
2019-02-27 05:11:40
@article{68740756-8db3-4ae5-bbfd-47614c80e96a,
  abstract     = {<p>Low cholesterol levels have been correlated with both suicidal and aggressive behavior in psychiatric patients. Few studies have investigated associations between serum lipid profiles and both aggressive state and trait. Fifty-two psychiatric medication-free inpatients were included in this study after a suicide attempt. Composite scores of “State Aggression” and “Trait Aggression” were calculated using relevant items from the Comprehensive Psychopathological Rating Scale and the Karolinska Scales of Personality. State Aggression was significantly and negatively correlated with total cholesterol (TC) and low-density lipoprotein (LDL). Trait Aggression was also significantly and negatively correlated with LDL, but not TC. There were small but significant mediation effects of severity of anxiety symptoms on the relationship between State Aggression and TC as well as LDL. In exploratory analyses we found that low cholesterol was also associated with personality traits of hostility. Moreover, low cholesterol was more robustly associated with personality trait items related to interpersonal aggression, as opposed to items related to irritability or more indirect, non-overt aggression. Our findings suggest that low cholesterol is associated with both state and trait aggression in suicide attempters. Future mechanistic studies are warranted to better understand the relationship between low cholesterol and high aggression in suicide attempters.</p>},
  author       = {Suneson, Klara and Asp, Marie and Träskman-Bendz, Lil and Westrin, Åsa and Ambrus, Livia and Lindqvist, Daniel},
  issn         = {0165-1781},
  keyword      = {Biological,Lipids,Personality,Psychiatry},
  language     = {eng},
  pages        = {430--434},
  publisher    = {Elsevier},
  series       = {Psychiatry Research},
  title        = {Low total cholesterol and low-density lipoprotein associated with aggression and hostility in recent suicide attempters},
  url          = {http://dx.doi.org/10.1016/j.psychres.2019.01.056},
  volume       = {273},
  year         = {2019},
}