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DNA-induced programmable fusion of phospholipid vesicles

Stengel, Gudrun LU ; Zahn, Raphael and Höök, Fredrik LU (2007) In Journal of the American Chemical Society 129(31). p.9584-9584
Abstract
In nature, the fusion of phospholipid vesicles is regulated and catalyzed by highly specialized SNARE proteins. A key step in this process is to bring about close apposition of the lipid bilayers that are destined to fuse. Inspired by nature's use of molecular recognition between receptor proteins, we developed a method to force bilayers into proximity by the selective hybridization of membrane-anchored DNA strands. We demonstrate that this forced bilayer contact triggers vesicle fusion.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of the American Chemical Society
volume
129
issue
31
pages
9584 - 9584
publisher
The American Chemical Society
external identifiers
  • wos:000248484400026
  • scopus:34547791948
ISSN
1520-5126
DOI
10.1021/ja073200k
language
English
LU publication?
yes
id
3ed27c0e-0404-40fc-a90c-9de07aa26d6b (old id 687881)
date added to LUP
2007-12-20 11:54:14
date last changed
2017-11-12 03:59:21
@article{3ed27c0e-0404-40fc-a90c-9de07aa26d6b,
  abstract     = {In nature, the fusion of phospholipid vesicles is regulated and catalyzed by highly specialized SNARE proteins. A key step in this process is to bring about close apposition of the lipid bilayers that are destined to fuse. Inspired by nature's use of molecular recognition between receptor proteins, we developed a method to force bilayers into proximity by the selective hybridization of membrane-anchored DNA strands. We demonstrate that this forced bilayer contact triggers vesicle fusion.},
  author       = {Stengel, Gudrun and Zahn, Raphael and Höök, Fredrik},
  issn         = {1520-5126},
  language     = {eng},
  number       = {31},
  pages        = {9584--9584},
  publisher    = {The American Chemical Society},
  series       = {Journal of the American Chemical Society},
  title        = {DNA-induced programmable fusion of phospholipid vesicles},
  url          = {http://dx.doi.org/10.1021/ja073200k},
  volume       = {129},
  year         = {2007},
}