DNA-induced programmable fusion of phospholipid vesicles
(2007) In Journal of the American Chemical Society 129(31). p.9584-9584- Abstract
- In nature, the fusion of phospholipid vesicles is regulated and catalyzed by highly specialized SNARE proteins. A key step in this process is to bring about close apposition of the lipid bilayers that are destined to fuse. Inspired by nature's use of molecular recognition between receptor proteins, we developed a method to force bilayers into proximity by the selective hybridization of membrane-anchored DNA strands. We demonstrate that this forced bilayer contact triggers vesicle fusion.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/687881
- author
- Stengel, Gudrun LU ; Zahn, Raphael and Höök, Fredrik LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of the American Chemical Society
- volume
- 129
- issue
- 31
- pages
- 9584 - 9584
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000248484400026
- scopus:34547791948
- ISSN
- 1520-5126
- DOI
- 10.1021/ja073200k
- language
- English
- LU publication?
- yes
- id
- 3ed27c0e-0404-40fc-a90c-9de07aa26d6b (old id 687881)
- date added to LUP
- 2016-04-01 16:28:10
- date last changed
- 2024-08-20 11:37:41
@article{3ed27c0e-0404-40fc-a90c-9de07aa26d6b, abstract = {{In nature, the fusion of phospholipid vesicles is regulated and catalyzed by highly specialized SNARE proteins. A key step in this process is to bring about close apposition of the lipid bilayers that are destined to fuse. Inspired by nature's use of molecular recognition between receptor proteins, we developed a method to force bilayers into proximity by the selective hybridization of membrane-anchored DNA strands. We demonstrate that this forced bilayer contact triggers vesicle fusion.}}, author = {{Stengel, Gudrun and Zahn, Raphael and Höök, Fredrik}}, issn = {{1520-5126}}, language = {{eng}}, number = {{31}}, pages = {{9584--9584}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Journal of the American Chemical Society}}, title = {{DNA-induced programmable fusion of phospholipid vesicles}}, url = {{http://dx.doi.org/10.1021/ja073200k}}, doi = {{10.1021/ja073200k}}, volume = {{129}}, year = {{2007}}, }