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Cryogelation for preparation of novel biodegradable tissue-engineering scaffolds

Boelgen, Nimet; Plieva, Fatima LU ; Galaev, Igor LU ; Mattiasson, Bo LU and Piskin, Erhan (2007) In Journal of Biomaterials Science. Polymer Edition 18(9). p.1165-1179
Abstract
2-Hydroxyethyl methacrylate-L-lactate (HEMA-LLA) and HEMA-L-lactate-dextran (HEMA-LLA-D) were synthesized. H-1-NMR confirmed the formation of these oligomers and macromers. Cryogels with different pore structures were prepared using different amounts of HEMA, HEMA-LLA and HEMA-LLA-D by a cryogelation technique. SEM micrographs exhibited pore morphologies. Cryogels were highly porous with interconnected pore structures, opaque, spongy and highly elastic. It was possible to compress them to remove the water in the pores and to return to their original form just by immersing them in water in few minutes, which was quite reproducible. Their swelling abilities, compressive strengths and degradation in buffer solutions were found to be related... (More)
2-Hydroxyethyl methacrylate-L-lactate (HEMA-LLA) and HEMA-L-lactate-dextran (HEMA-LLA-D) were synthesized. H-1-NMR confirmed the formation of these oligomers and macromers. Cryogels with different pore structures were prepared using different amounts of HEMA, HEMA-LLA and HEMA-LLA-D by a cryogelation technique. SEM micrographs exhibited pore morphologies. Cryogels were highly porous with interconnected pore structures, opaque, spongy and highly elastic. It was possible to compress them to remove the water in the pores and to return to their original form just by immersing them in water in few minutes, which was quite reproducible. Their swelling abilities, compressive strengths and degradation in buffer solutions were found to be related with their structural properties which was controlled by changing the cryogelation recipe. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
HEMA-L-lactate, HEMA, scaffold for tissue engineering, cryogelation, degradable cryogels, HEMA-L-lactate-dextran
in
Journal of Biomaterials Science. Polymer Edition
volume
18
issue
9
pages
1165 - 1179
publisher
VSP BV
external identifiers
  • wos:000249315400005
  • scopus:35048840133
ISSN
0920-5063
DOI
10.1163/156856207781554064
language
English
LU publication?
yes
id
1a187326-9101-4b7c-9f17-3c56645a72bd (old id 687970)
date added to LUP
2007-12-11 14:04:43
date last changed
2017-05-28 04:27:39
@article{1a187326-9101-4b7c-9f17-3c56645a72bd,
  abstract     = {2-Hydroxyethyl methacrylate-L-lactate (HEMA-LLA) and HEMA-L-lactate-dextran (HEMA-LLA-D) were synthesized. H-1-NMR confirmed the formation of these oligomers and macromers. Cryogels with different pore structures were prepared using different amounts of HEMA, HEMA-LLA and HEMA-LLA-D by a cryogelation technique. SEM micrographs exhibited pore morphologies. Cryogels were highly porous with interconnected pore structures, opaque, spongy and highly elastic. It was possible to compress them to remove the water in the pores and to return to their original form just by immersing them in water in few minutes, which was quite reproducible. Their swelling abilities, compressive strengths and degradation in buffer solutions were found to be related with their structural properties which was controlled by changing the cryogelation recipe.},
  author       = {Boelgen, Nimet and Plieva, Fatima and Galaev, Igor and Mattiasson, Bo and Piskin, Erhan},
  issn         = {0920-5063},
  keyword      = {HEMA-L-lactate,HEMA,scaffold for tissue engineering,cryogelation,degradable cryogels,HEMA-L-lactate-dextran},
  language     = {eng},
  number       = {9},
  pages        = {1165--1179},
  publisher    = {VSP BV},
  series       = {Journal of Biomaterials Science. Polymer Edition},
  title        = {Cryogelation for preparation of novel biodegradable tissue-engineering scaffolds},
  url          = {http://dx.doi.org/10.1163/156856207781554064},
  volume       = {18},
  year         = {2007},
}