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Trends in medication and health-related quality of life in a population-based rheumatoid arthritis register in Malmo, Sweden

Söderlin, Maria LU ; Lindroth, Y. and Jacobsson, L. T. H. (2007) In Rheumatology 46(8). p.1355-1358
Abstract
Objectives. To study trends in treatment, health status and health-related quality of life (HRQL) in two cross-sectional surveys over a 5-yr period and in an observational follow-up sub-cohort based on a population-based rheumatoid arthritis (RA) register in Malm6, Sweden. Material and methods. A continuously updated population-based RA register was established in Malm6 city in southern Sweden in 1997. Patient-administered questionnaires in 1997 and 2002 were used to collect information on demographics, medication and health status. Cross-sectional comparisons were made between 1997 and 2002. A longitudinal analysis was also performed in the RA patients participating in both surveys. Results. Increased proportions of patients were treated... (More)
Objectives. To study trends in treatment, health status and health-related quality of life (HRQL) in two cross-sectional surveys over a 5-yr period and in an observational follow-up sub-cohort based on a population-based rheumatoid arthritis (RA) register in Malm6, Sweden. Material and methods. A continuously updated population-based RA register was established in Malm6 city in southern Sweden in 1997. Patient-administered questionnaires in 1997 and 2002 were used to collect information on demographics, medication and health status. Cross-sectional comparisons were made between 1997 and 2002. A longitudinal analysis was also performed in the RA patients participating in both surveys. Results. Increased proportions of patients were treated with disease-modifying anti-rheumatic drugs (DMARDs) (69 vs 52%), corticosteroids (30 vs 23%), methotrexate (52 vs 29%) and biologics (14 vs 0%) in 2002 compared with 1997. In the cross-sectional analysis, the visual analogue scores (VAS) for pain and general health and the short form 36 (SF-36) domains were slightly better in 2002 than in 1997. In the observational sub-cohort, patients treated with biologics improved significantly in several measures of health status, whereas those starting on methotrexate or undergoing other or no changes in DMARD therapy did not. Conclusions. In this population-based RA cohort, patients were more actively treated in 2002. Small improvements were seen in health status and these improvements were exclusively attributable to treatment with biologics. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
SF-36, rheumatoid arthritis, health-related quality of life, biologics, epidemiology
in
Rheumatology
volume
46
issue
8
pages
1355 - 1358
publisher
Oxford University Press
external identifiers
  • wos:000248686800025
  • scopus:34547839820
ISSN
1462-0332
DOI
10.1093/rheumatology/kem143
language
English
LU publication?
yes
id
e3d28ef4-873a-46fb-97be-7f0210106b40 (old id 688649)
date added to LUP
2007-12-19 09:11:55
date last changed
2017-01-01 06:45:25
@article{e3d28ef4-873a-46fb-97be-7f0210106b40,
  abstract     = {Objectives. To study trends in treatment, health status and health-related quality of life (HRQL) in two cross-sectional surveys over a 5-yr period and in an observational follow-up sub-cohort based on a population-based rheumatoid arthritis (RA) register in Malm6, Sweden. Material and methods. A continuously updated population-based RA register was established in Malm6 city in southern Sweden in 1997. Patient-administered questionnaires in 1997 and 2002 were used to collect information on demographics, medication and health status. Cross-sectional comparisons were made between 1997 and 2002. A longitudinal analysis was also performed in the RA patients participating in both surveys. Results. Increased proportions of patients were treated with disease-modifying anti-rheumatic drugs (DMARDs) (69 vs 52%), corticosteroids (30 vs 23%), methotrexate (52 vs 29%) and biologics (14 vs 0%) in 2002 compared with 1997. In the cross-sectional analysis, the visual analogue scores (VAS) for pain and general health and the short form 36 (SF-36) domains were slightly better in 2002 than in 1997. In the observational sub-cohort, patients treated with biologics improved significantly in several measures of health status, whereas those starting on methotrexate or undergoing other or no changes in DMARD therapy did not. Conclusions. In this population-based RA cohort, patients were more actively treated in 2002. Small improvements were seen in health status and these improvements were exclusively attributable to treatment with biologics.},
  author       = {Söderlin, Maria and Lindroth, Y. and Jacobsson, L. T. H.},
  issn         = {1462-0332},
  keyword      = {SF-36,rheumatoid arthritis,health-related quality of life,biologics,epidemiology},
  language     = {eng},
  number       = {8},
  pages        = {1355--1358},
  publisher    = {Oxford University Press},
  series       = {Rheumatology},
  title        = {Trends in medication and health-related quality of life in a population-based rheumatoid arthritis register in Malmo, Sweden},
  url          = {http://dx.doi.org/10.1093/rheumatology/kem143},
  volume       = {46},
  year         = {2007},
}