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Progression parameters for emphysema: A clinical investigation

Stolk, Jan; Putter, Hein; Bakker, Els M.; Shaker, Saher B.; Parre, David G.; Piitulainen, Eeva LU ; Russi, Erich W.; Grebski, Elzbieta; Dirksen, Asger and Stockley, Robert A., et al. (2007) In Respiratory Medicine 101(9). p.1924-1930
Abstract
In patients with airflow limitation caused by cigarette smoking, lung density measured by computed tomography is strongly correlated with quantitative pathology scores of emphysema, but the ability of lung densitometry to detect progression of emphysema is disputed. We assessed the sensitivity of lung densitometry as a parameter of disease progression of emphysema in comparison to FEV1 and gas transfer. At study baseline and after 30 months we measured computed tomography (CT)-derived lung density, spirometry and carbon monoxide diffusion coefficient in 144 patients with chronic obstructive pulmonary disease (COPD) in five different centers. Annual change in lung density was 1.31 g/L/year (CI 95%: -2.12 to -0.50 HU, p = 0.0015, 39.5... (More)
In patients with airflow limitation caused by cigarette smoking, lung density measured by computed tomography is strongly correlated with quantitative pathology scores of emphysema, but the ability of lung densitometry to detect progression of emphysema is disputed. We assessed the sensitivity of lung densitometry as a parameter of disease progression of emphysema in comparison to FEV1 and gas transfer. At study baseline and after 30 months we measured computed tomography (CT)-derived lung density, spirometry and carbon monoxide diffusion coefficient in 144 patients with chronic obstructive pulmonary disease (COPD) in five different centers. Annual change in lung density was 1.31 g/L/year (CI 95%: -2.12 to -0.50 HU, p = 0.0015, 39.5 mL/year (CI 95%: -100.0-21.0 mL, p = 0.2) for FEV1, (-39.5 mL) and 24.3 mu mol/min/kPa/L/year for gas transfer (CI 95%: -61.0-12.5 mu mol/min/kPa/L/year, p = 0.2). Signal-to-noise ratio (mean change divided by standard error of the change) for the detection of annual change was 3.2 for lung densitometry, but 1.3 for both FEV1 and gas diffusion. We conclude that detection of progression of emphysema was found to be 2.5-fold more sensitive using lung densitometry than by using currently recommended lung function parameters. Our results support CT scan as an efficacious test for novel drugs for emphysema. (c) 2007 Published by Elsevier Ltd. (Less)
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publication status
published
subject
keywords
lung densitometry, airflow limitation, alveolar destruction
in
Respiratory Medicine
volume
101
issue
9
pages
1924 - 1930
publisher
Elsevier
external identifiers
  • wos:000249092300010
  • scopus:34547476189
ISSN
1532-3064
DOI
10.1016/j.rmed.2007.04.016
language
English
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yes
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7c39fb5b-d4ef-49a0-8dd1-26d2a82cd7f8 (old id 688658)
date added to LUP
2007-12-19 10:34:35
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2017-10-01 04:34:38
@article{7c39fb5b-d4ef-49a0-8dd1-26d2a82cd7f8,
  abstract     = {In patients with airflow limitation caused by cigarette smoking, lung density measured by computed tomography is strongly correlated with quantitative pathology scores of emphysema, but the ability of lung densitometry to detect progression of emphysema is disputed. We assessed the sensitivity of lung densitometry as a parameter of disease progression of emphysema in comparison to FEV1 and gas transfer. At study baseline and after 30 months we measured computed tomography (CT)-derived lung density, spirometry and carbon monoxide diffusion coefficient in 144 patients with chronic obstructive pulmonary disease (COPD) in five different centers. Annual change in lung density was 1.31 g/L/year (CI 95%: -2.12 to -0.50 HU, p = 0.0015, 39.5 mL/year (CI 95%: -100.0-21.0 mL, p = 0.2) for FEV1, (-39.5 mL) and 24.3 mu mol/min/kPa/L/year for gas transfer (CI 95%: -61.0-12.5 mu mol/min/kPa/L/year, p = 0.2). Signal-to-noise ratio (mean change divided by standard error of the change) for the detection of annual change was 3.2 for lung densitometry, but 1.3 for both FEV1 and gas diffusion. We conclude that detection of progression of emphysema was found to be 2.5-fold more sensitive using lung densitometry than by using currently recommended lung function parameters. Our results support CT scan as an efficacious test for novel drugs for emphysema. (c) 2007 Published by Elsevier Ltd.},
  author       = {Stolk, Jan and Putter, Hein and Bakker, Els M. and Shaker, Saher B. and Parre, David G. and Piitulainen, Eeva and Russi, Erich W. and Grebski, Elzbieta and Dirksen, Asger and Stockley, Robert A. and Reiber, Johan H. C. and Stoel, Berend C.},
  issn         = {1532-3064},
  keyword      = {lung densitometry,airflow limitation,alveolar destruction},
  language     = {eng},
  number       = {9},
  pages        = {1924--1930},
  publisher    = {Elsevier},
  series       = {Respiratory Medicine},
  title        = {Progression parameters for emphysema: A clinical investigation},
  url          = {http://dx.doi.org/10.1016/j.rmed.2007.04.016},
  volume       = {101},
  year         = {2007},
}