Validity and reproducibility of HOMA-IR, 1/HOMA-IR, QUICKI and McAuley's indices in patients with hypertension and type II diabetes
(2007) In Journal of Human Hypertension 21(9). p.709-716- Abstract
- The aim of this study was to evaluate the validity and reliability of homeostasis model assessment-insulin resistance (HOMA-IR) index, its reciprocal (1/HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and McAuley's index in hypertensive diabetic patients. In 78 patients with hypertension and type II diabetes glucose, insulin and triglyceride levels were determined after a 12-h fast to calculate these indices, and insulin sensitivity (IS) was measured with the hyperinsulinemic euglycemic clamp technique. Two weeks later, subjects had again their glucose, insulin and triglycerides measured. Simple and multiple linear regression analysis were applied to assess the validity of these indices compared to clamp IS and coefficients... (More)
- The aim of this study was to evaluate the validity and reliability of homeostasis model assessment-insulin resistance (HOMA-IR) index, its reciprocal (1/HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and McAuley's index in hypertensive diabetic patients. In 78 patients with hypertension and type II diabetes glucose, insulin and triglyceride levels were determined after a 12-h fast to calculate these indices, and insulin sensitivity (IS) was measured with the hyperinsulinemic euglycemic clamp technique. Two weeks later, subjects had again their glucose, insulin and triglycerides measured. Simple and multiple linear regression analysis were applied to assess the validity of these indices compared to clamp IS and coefficients of variation between the two visits were estimated to assess their reproducibility. HOMA-IR index was strongly and inversely correlated with the basic IS clamp index, the M-value (r = 0.572, P < 0.001), M- value normalized with subjects' body weight or fat-free mass and every other clamp-derived index. 1/HOMA-IR and QUICKI indices were positively correlated with the M- value (r = 0.342, P < 0.05 and r = 0.456, P < 0.01, respectively) and the rest clamp indices. McAuley's index generally presented less strong correlations ( r = 0.317, P < 0.05 with M- value). In multivariate analysis, HOMA-IR was the best fit of clampderived IS. Coefficients of variation between the two visits were 23.5% for HOMA-IR, 19.2% for 1/HOMA-IR, 7.8% for QUICKI and 15.1% for McAuley's index. In conclusion, HOMA- IR, 1/HOMA-IR and QUICKI are valid estimates of clamp-derived IS in patients with hypertension and type II diabetes, whereas the validity of McAuley's index needs further evaluation. QUICKI displayed better reproducibility than the other indices. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/688934
- author
- Sarafidis, P. A. ; Lasaridis, A. N. ; Nilsson, Peter LU ; Pikilidou, M. I. ; Stafilas, P. C. ; Kanaki, A. ; Kazakos, K. ; Yovos, J. and Bakris, G. L.
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- QUICKI, insulin resistance, HOMA-IR, McAuley's index
- in
- Journal of Human Hypertension
- volume
- 21
- issue
- 9
- pages
- 709 - 716
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000248968300004
- scopus:34548336411
- ISSN
- 1476-5527
- DOI
- 10.1038/sj.jhh.1002201
- language
- English
- LU publication?
- yes
- id
- 44c89fb6-2bb8-43e3-b81f-93433d37bbd4 (old id 688934)
- date added to LUP
- 2016-04-01 12:10:37
- date last changed
- 2022-04-21 03:31:24
@article{44c89fb6-2bb8-43e3-b81f-93433d37bbd4,
abstract = {{The aim of this study was to evaluate the validity and reliability of homeostasis model assessment-insulin resistance (HOMA-IR) index, its reciprocal (1/HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and McAuley's index in hypertensive diabetic patients. In 78 patients with hypertension and type II diabetes glucose, insulin and triglyceride levels were determined after a 12-h fast to calculate these indices, and insulin sensitivity (IS) was measured with the hyperinsulinemic euglycemic clamp technique. Two weeks later, subjects had again their glucose, insulin and triglycerides measured. Simple and multiple linear regression analysis were applied to assess the validity of these indices compared to clamp IS and coefficients of variation between the two visits were estimated to assess their reproducibility. HOMA-IR index was strongly and inversely correlated with the basic IS clamp index, the M-value (r = 0.572, P < 0.001), M- value normalized with subjects' body weight or fat-free mass and every other clamp-derived index. 1/HOMA-IR and QUICKI indices were positively correlated with the M- value (r = 0.342, P < 0.05 and r = 0.456, P < 0.01, respectively) and the rest clamp indices. McAuley's index generally presented less strong correlations ( r = 0.317, P < 0.05 with M- value). In multivariate analysis, HOMA-IR was the best fit of clampderived IS. Coefficients of variation between the two visits were 23.5% for HOMA-IR, 19.2% for 1/HOMA-IR, 7.8% for QUICKI and 15.1% for McAuley's index. In conclusion, HOMA- IR, 1/HOMA-IR and QUICKI are valid estimates of clamp-derived IS in patients with hypertension and type II diabetes, whereas the validity of McAuley's index needs further evaluation. QUICKI displayed better reproducibility than the other indices.}},
author = {{Sarafidis, P. A. and Lasaridis, A. N. and Nilsson, Peter and Pikilidou, M. I. and Stafilas, P. C. and Kanaki, A. and Kazakos, K. and Yovos, J. and Bakris, G. L.}},
issn = {{1476-5527}},
keywords = {{QUICKI; insulin resistance; HOMA-IR; McAuley's index}},
language = {{eng}},
number = {{9}},
pages = {{709--716}},
publisher = {{Nature Publishing Group}},
series = {{Journal of Human Hypertension}},
title = {{Validity and reproducibility of HOMA-IR, 1/HOMA-IR, QUICKI and McAuley's indices in patients with hypertension and type II diabetes}},
url = {{http://dx.doi.org/10.1038/sj.jhh.1002201}},
doi = {{10.1038/sj.jhh.1002201}},
volume = {{21}},
year = {{2007}},
}