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Validity and reproducibility of HOMA-IR, 1/HOMA-IR, QUICKI and McAuley's indices in patients with hypertension and type II diabetes

Sarafidis, P. A.; Lasaridis, A. N.; Nilsson, Peter LU ; Pikilidou, M. I.; Stafilas, P. C.; Kanaki, A.; Kazakos, K.; Yovos, J. and Bakris, G. L. (2007) In Journal of Human Hypertension 21(9). p.709-716
Abstract
The aim of this study was to evaluate the validity and reliability of homeostasis model assessment-insulin resistance (HOMA-IR) index, its reciprocal (1/HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and McAuley's index in hypertensive diabetic patients. In 78 patients with hypertension and type II diabetes glucose, insulin and triglyceride levels were determined after a 12-h fast to calculate these indices, and insulin sensitivity (IS) was measured with the hyperinsulinemic euglycemic clamp technique. Two weeks later, subjects had again their glucose, insulin and triglycerides measured. Simple and multiple linear regression analysis were applied to assess the validity of these indices compared to clamp IS and coefficients... (More)
The aim of this study was to evaluate the validity and reliability of homeostasis model assessment-insulin resistance (HOMA-IR) index, its reciprocal (1/HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and McAuley's index in hypertensive diabetic patients. In 78 patients with hypertension and type II diabetes glucose, insulin and triglyceride levels were determined after a 12-h fast to calculate these indices, and insulin sensitivity (IS) was measured with the hyperinsulinemic euglycemic clamp technique. Two weeks later, subjects had again their glucose, insulin and triglycerides measured. Simple and multiple linear regression analysis were applied to assess the validity of these indices compared to clamp IS and coefficients of variation between the two visits were estimated to assess their reproducibility. HOMA-IR index was strongly and inversely correlated with the basic IS clamp index, the M-value (r = 0.572, P < 0.001), M- value normalized with subjects' body weight or fat-free mass and every other clamp-derived index. 1/HOMA-IR and QUICKI indices were positively correlated with the M- value (r = 0.342, P < 0.05 and r = 0.456, P < 0.01, respectively) and the rest clamp indices. McAuley's index generally presented less strong correlations ( r = 0.317, P < 0.05 with M- value). In multivariate analysis, HOMA-IR was the best fit of clampderived IS. Coefficients of variation between the two visits were 23.5% for HOMA-IR, 19.2% for 1/HOMA-IR, 7.8% for QUICKI and 15.1% for McAuley's index. In conclusion, HOMA- IR, 1/HOMA-IR and QUICKI are valid estimates of clamp-derived IS in patients with hypertension and type II diabetes, whereas the validity of McAuley's index needs further evaluation. QUICKI displayed better reproducibility than the other indices. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
QUICKI, insulin resistance, HOMA-IR, McAuley's index
in
Journal of Human Hypertension
volume
21
issue
9
pages
709 - 716
publisher
Nature Publishing Group
external identifiers
  • wos:000248968300004
  • scopus:34548336411
ISSN
1476-5527
DOI
10.1038/sj.jhh.1002201
language
English
LU publication?
yes
id
44c89fb6-2bb8-43e3-b81f-93433d37bbd4 (old id 688934)
date added to LUP
2007-12-18 13:57:14
date last changed
2017-10-29 03:36:26
@article{44c89fb6-2bb8-43e3-b81f-93433d37bbd4,
  abstract     = {The aim of this study was to evaluate the validity and reliability of homeostasis model assessment-insulin resistance (HOMA-IR) index, its reciprocal (1/HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and McAuley's index in hypertensive diabetic patients. In 78 patients with hypertension and type II diabetes glucose, insulin and triglyceride levels were determined after a 12-h fast to calculate these indices, and insulin sensitivity (IS) was measured with the hyperinsulinemic euglycemic clamp technique. Two weeks later, subjects had again their glucose, insulin and triglycerides measured. Simple and multiple linear regression analysis were applied to assess the validity of these indices compared to clamp IS and coefficients of variation between the two visits were estimated to assess their reproducibility. HOMA-IR index was strongly and inversely correlated with the basic IS clamp index, the M-value (r = 0.572, P &lt; 0.001), M- value normalized with subjects' body weight or fat-free mass and every other clamp-derived index. 1/HOMA-IR and QUICKI indices were positively correlated with the M- value (r = 0.342, P &lt; 0.05 and r = 0.456, P &lt; 0.01, respectively) and the rest clamp indices. McAuley's index generally presented less strong correlations ( r = 0.317, P &lt; 0.05 with M- value). In multivariate analysis, HOMA-IR was the best fit of clampderived IS. Coefficients of variation between the two visits were 23.5% for HOMA-IR, 19.2% for 1/HOMA-IR, 7.8% for QUICKI and 15.1% for McAuley's index. In conclusion, HOMA- IR, 1/HOMA-IR and QUICKI are valid estimates of clamp-derived IS in patients with hypertension and type II diabetes, whereas the validity of McAuley's index needs further evaluation. QUICKI displayed better reproducibility than the other indices.},
  author       = {Sarafidis, P. A. and Lasaridis, A. N. and Nilsson, Peter and Pikilidou, M. I. and Stafilas, P. C. and Kanaki, A. and Kazakos, K. and Yovos, J. and Bakris, G. L.},
  issn         = {1476-5527},
  keyword      = {QUICKI,insulin resistance,HOMA-IR,McAuley's index},
  language     = {eng},
  number       = {9},
  pages        = {709--716},
  publisher    = {Nature Publishing Group},
  series       = {Journal of Human Hypertension},
  title        = {Validity and reproducibility of HOMA-IR, 1/HOMA-IR, QUICKI and McAuley's indices in patients with hypertension and type II diabetes},
  url          = {http://dx.doi.org/10.1038/sj.jhh.1002201},
  volume       = {21},
  year         = {2007},
}