Sentinel node biopsy for breast cancer larger than 3 cm in diameter
(2007) In British Journal of Surgery 94(8). p.948-951- Abstract
- Background: Sentinel node biopsy (SNB) is a standard staging procedure in early breast cancer. Its suitability for larger tumours has been questioned. This study evaluated the reliability of SNB in women with invasive breast cancer larger than 3 cm in diameter who were clinically axillary node negative. Methods: Some 109 women with a turnout larger than 3 cm on pathological analysis were identified from the Swedish prospective SNB database. They were included if a completion axillary clearance was planned, regardless of SNB results. Results: The sentinel node detection rate was 103 (94.5 per cent) of 109. The overall false-negative rate was eight (13 per cent) of 64. Although a preoperative diagnosis of multifocal turnout was an exclusion... (More)
- Background: Sentinel node biopsy (SNB) is a standard staging procedure in early breast cancer. Its suitability for larger tumours has been questioned. This study evaluated the reliability of SNB in women with invasive breast cancer larger than 3 cm in diameter who were clinically axillary node negative. Methods: Some 109 women with a turnout larger than 3 cm on pathological analysis were identified from the Swedish prospective SNB database. They were included if a completion axillary clearance was planned, regardless of SNB results. Results: The sentinel node detection rate was 103 (94.5 per cent) of 109. The overall false-negative rate was eight (13 per cent) of 64. Although a preoperative diagnosis of multifocal turnout was an exclusion criterion, 16 such cases were revealed on postoperative pathological examination. The false-negative rate in this subgroup was higher than that in women with a unifocal tumour (four (31 per cent) of 13 versus four (8 per cent) of 51; P = 0.012). No other significant predictors of a false-negative sentinel node biopsy were identified. Conclusion: SNB is feasible in patients with unifocal breast tumours larger than 3 cm. When large tumour size coincides with multifocality, however, the false-negative rate seems to be increased and a completion axillary clearance should be considered even if the SNB is negative. (Less)
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https://lup.lub.lu.se/record/689601
- author
- Schule, J. ; Frisell, J. ; Ingvar, Christian LU and Bergkvist, L.
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Surgery
- volume
- 94
- issue
- 8
- pages
- 948 - 951
- publisher
- Oxford University Press
- external identifiers
-
- wos:000248921700006
- scopus:34547762285
- pmid:17436338
- ISSN
- 1365-2168
- DOI
- 10.1002/bjs.5713
- language
- English
- LU publication?
- yes
- id
- b04f2863-8eb6-49b3-8867-d2cd6c9f91db (old id 689601)
- date added to LUP
- 2016-04-01 11:34:30
- date last changed
- 2022-01-26 07:15:01
@article{b04f2863-8eb6-49b3-8867-d2cd6c9f91db,
abstract = {{Background: Sentinel node biopsy (SNB) is a standard staging procedure in early breast cancer. Its suitability for larger tumours has been questioned. This study evaluated the reliability of SNB in women with invasive breast cancer larger than 3 cm in diameter who were clinically axillary node negative. Methods: Some 109 women with a turnout larger than 3 cm on pathological analysis were identified from the Swedish prospective SNB database. They were included if a completion axillary clearance was planned, regardless of SNB results. Results: The sentinel node detection rate was 103 (94.5 per cent) of 109. The overall false-negative rate was eight (13 per cent) of 64. Although a preoperative diagnosis of multifocal turnout was an exclusion criterion, 16 such cases were revealed on postoperative pathological examination. The false-negative rate in this subgroup was higher than that in women with a unifocal tumour (four (31 per cent) of 13 versus four (8 per cent) of 51; P = 0.012). No other significant predictors of a false-negative sentinel node biopsy were identified. Conclusion: SNB is feasible in patients with unifocal breast tumours larger than 3 cm. When large tumour size coincides with multifocality, however, the false-negative rate seems to be increased and a completion axillary clearance should be considered even if the SNB is negative.}},
author = {{Schule, J. and Frisell, J. and Ingvar, Christian and Bergkvist, L.}},
issn = {{1365-2168}},
language = {{eng}},
number = {{8}},
pages = {{948--951}},
publisher = {{Oxford University Press}},
series = {{British Journal of Surgery}},
title = {{Sentinel node biopsy for breast cancer larger than 3 cm in diameter}},
url = {{http://dx.doi.org/10.1002/bjs.5713}},
doi = {{10.1002/bjs.5713}},
volume = {{94}},
year = {{2007}},
}