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Sentinel node biopsy for breast cancer larger than 3 cm in diameter

Schule, J.; Frisell, J.; Ingvar, Christian LU and Bergkvist, L. (2007) In British Journal of Surgery 94(8). p.948-951
Abstract
Background: Sentinel node biopsy (SNB) is a standard staging procedure in early breast cancer. Its suitability for larger tumours has been questioned. This study evaluated the reliability of SNB in women with invasive breast cancer larger than 3 cm in diameter who were clinically axillary node negative. Methods: Some 109 women with a turnout larger than 3 cm on pathological analysis were identified from the Swedish prospective SNB database. They were included if a completion axillary clearance was planned, regardless of SNB results. Results: The sentinel node detection rate was 103 (94.5 per cent) of 109. The overall false-negative rate was eight (13 per cent) of 64. Although a preoperative diagnosis of multifocal turnout was an exclusion... (More)
Background: Sentinel node biopsy (SNB) is a standard staging procedure in early breast cancer. Its suitability for larger tumours has been questioned. This study evaluated the reliability of SNB in women with invasive breast cancer larger than 3 cm in diameter who were clinically axillary node negative. Methods: Some 109 women with a turnout larger than 3 cm on pathological analysis were identified from the Swedish prospective SNB database. They were included if a completion axillary clearance was planned, regardless of SNB results. Results: The sentinel node detection rate was 103 (94.5 per cent) of 109. The overall false-negative rate was eight (13 per cent) of 64. Although a preoperative diagnosis of multifocal turnout was an exclusion criterion, 16 such cases were revealed on postoperative pathological examination. The false-negative rate in this subgroup was higher than that in women with a unifocal tumour (four (31 per cent) of 13 versus four (8 per cent) of 51; P = 0.012). No other significant predictors of a false-negative sentinel node biopsy were identified. Conclusion: SNB is feasible in patients with unifocal breast tumours larger than 3 cm. When large tumour size coincides with multifocality, however, the false-negative rate seems to be increased and a completion axillary clearance should be considered even if the SNB is negative. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Surgery
volume
94
issue
8
pages
948 - 951
publisher
John Wiley & Sons
external identifiers
  • wos:000248921700006
  • scopus:34547762285
ISSN
1365-2168
DOI
10.1002/bjs.5713
language
English
LU publication?
yes
id
b04f2863-8eb6-49b3-8867-d2cd6c9f91db (old id 689601)
date added to LUP
2007-12-18 09:31:07
date last changed
2017-09-17 04:28:32
@article{b04f2863-8eb6-49b3-8867-d2cd6c9f91db,
  abstract     = {Background: Sentinel node biopsy (SNB) is a standard staging procedure in early breast cancer. Its suitability for larger tumours has been questioned. This study evaluated the reliability of SNB in women with invasive breast cancer larger than 3 cm in diameter who were clinically axillary node negative. Methods: Some 109 women with a turnout larger than 3 cm on pathological analysis were identified from the Swedish prospective SNB database. They were included if a completion axillary clearance was planned, regardless of SNB results. Results: The sentinel node detection rate was 103 (94.5 per cent) of 109. The overall false-negative rate was eight (13 per cent) of 64. Although a preoperative diagnosis of multifocal turnout was an exclusion criterion, 16 such cases were revealed on postoperative pathological examination. The false-negative rate in this subgroup was higher than that in women with a unifocal tumour (four (31 per cent) of 13 versus four (8 per cent) of 51; P = 0.012). No other significant predictors of a false-negative sentinel node biopsy were identified. Conclusion: SNB is feasible in patients with unifocal breast tumours larger than 3 cm. When large tumour size coincides with multifocality, however, the false-negative rate seems to be increased and a completion axillary clearance should be considered even if the SNB is negative.},
  author       = {Schule, J. and Frisell, J. and Ingvar, Christian and Bergkvist, L.},
  issn         = {1365-2168},
  language     = {eng},
  number       = {8},
  pages        = {948--951},
  publisher    = {John Wiley & Sons},
  series       = {British Journal of Surgery},
  title        = {Sentinel node biopsy for breast cancer larger than 3 cm in diameter},
  url          = {http://dx.doi.org/10.1002/bjs.5713},
  volume       = {94},
  year         = {2007},
}