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Neutrophil granules: a library of innate immunity proteins

Borregaard, Niels; Sørensen, Ole E LU and Theilgaard-Wnchl, Kim (2007) In Trends in Immunology 28(8). p.340-345
Abstract
Gene expression profiling has revealed that circulating neutrophils rest between two major bursts of transcriptional and protein synthetic activities. The first occurs in the bone marrow. This equips the neutrophil with stocks of innate defense armory that are packaged into different granule subsets. The second burst occurs when the neutrophil exits circulation and migrates into tissues to find, capture and phagocytose microorganisms. This burst results in the synthesis and secretion of cytokines and chemokines that support resolution of inflammation and healing of damaged tissue. Gene expression profiling has revealed that neutrophils express a variety of innate immunity proteins, known previously only to be expressed in other cells.... (More)
Gene expression profiling has revealed that circulating neutrophils rest between two major bursts of transcriptional and protein synthetic activities. The first occurs in the bone marrow. This equips the neutrophil with stocks of innate defense armory that are packaged into different granule subsets. The second burst occurs when the neutrophil exits circulation and migrates into tissues to find, capture and phagocytose microorganisms. This burst results in the synthesis and secretion of cytokines and chemokines that support resolution of inflammation and healing of damaged tissue. Gene expression profiling has revealed that neutrophils express a variety of innate immunity proteins, known previously only to be expressed in other cells. Likewise, it has become clear that some proteins previously thought to be specific to the neutrophil are expressed in epithelial cells during inflammation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Immunology
volume
28
issue
8
pages
340 - 345
publisher
Elsevier
external identifiers
  • wos:000248883500003
  • scopus:34447561633
ISSN
1471-4981
DOI
10.1016/j.it.2007.06.002
language
English
LU publication?
yes
id
1702e33a-268b-4125-87b3-ba0c2b4ec795 (old id 689754)
date added to LUP
2007-12-05 11:45:03
date last changed
2017-11-19 03:30:51
@article{1702e33a-268b-4125-87b3-ba0c2b4ec795,
  abstract     = {Gene expression profiling has revealed that circulating neutrophils rest between two major bursts of transcriptional and protein synthetic activities. The first occurs in the bone marrow. This equips the neutrophil with stocks of innate defense armory that are packaged into different granule subsets. The second burst occurs when the neutrophil exits circulation and migrates into tissues to find, capture and phagocytose microorganisms. This burst results in the synthesis and secretion of cytokines and chemokines that support resolution of inflammation and healing of damaged tissue. Gene expression profiling has revealed that neutrophils express a variety of innate immunity proteins, known previously only to be expressed in other cells. Likewise, it has become clear that some proteins previously thought to be specific to the neutrophil are expressed in epithelial cells during inflammation.},
  author       = {Borregaard, Niels and Sørensen, Ole E and Theilgaard-Wnchl, Kim},
  issn         = {1471-4981},
  language     = {eng},
  number       = {8},
  pages        = {340--345},
  publisher    = {Elsevier},
  series       = {Trends in Immunology},
  title        = {Neutrophil granules: a library of innate immunity proteins},
  url          = {http://dx.doi.org/10.1016/j.it.2007.06.002},
  volume       = {28},
  year         = {2007},
}