Neutrophil granules: a library of innate immunity proteins
(2007) In Trends in Immunology 28(8). p.340-345- Abstract
- Gene expression profiling has revealed that circulating neutrophils rest between two major bursts of transcriptional and protein synthetic activities. The first occurs in the bone marrow. This equips the neutrophil with stocks of innate defense armory that are packaged into different granule subsets. The second burst occurs when the neutrophil exits circulation and migrates into tissues to find, capture and phagocytose microorganisms. This burst results in the synthesis and secretion of cytokines and chemokines that support resolution of inflammation and healing of damaged tissue. Gene expression profiling has revealed that neutrophils express a variety of innate immunity proteins, known previously only to be expressed in other cells.... (More)
- Gene expression profiling has revealed that circulating neutrophils rest between two major bursts of transcriptional and protein synthetic activities. The first occurs in the bone marrow. This equips the neutrophil with stocks of innate defense armory that are packaged into different granule subsets. The second burst occurs when the neutrophil exits circulation and migrates into tissues to find, capture and phagocytose microorganisms. This burst results in the synthesis and secretion of cytokines and chemokines that support resolution of inflammation and healing of damaged tissue. Gene expression profiling has revealed that neutrophils express a variety of innate immunity proteins, known previously only to be expressed in other cells. Likewise, it has become clear that some proteins previously thought to be specific to the neutrophil are expressed in epithelial cells during inflammation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/689754
- author
- Borregaard, Niels ; Sørensen, Ole E LU and Theilgaard-Wnchl, Kim
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Immunology
- volume
- 28
- issue
- 8
- pages
- 340 - 345
- publisher
- Elsevier
- external identifiers
-
- wos:000248883500003
- scopus:34447561633
- ISSN
- 1471-4981
- DOI
- 10.1016/j.it.2007.06.002
- language
- English
- LU publication?
- yes
- id
- 1702e33a-268b-4125-87b3-ba0c2b4ec795 (old id 689754)
- date added to LUP
- 2016-04-01 11:58:16
- date last changed
- 2022-04-21 00:25:32
@article{1702e33a-268b-4125-87b3-ba0c2b4ec795,
abstract = {{Gene expression profiling has revealed that circulating neutrophils rest between two major bursts of transcriptional and protein synthetic activities. The first occurs in the bone marrow. This equips the neutrophil with stocks of innate defense armory that are packaged into different granule subsets. The second burst occurs when the neutrophil exits circulation and migrates into tissues to find, capture and phagocytose microorganisms. This burst results in the synthesis and secretion of cytokines and chemokines that support resolution of inflammation and healing of damaged tissue. Gene expression profiling has revealed that neutrophils express a variety of innate immunity proteins, known previously only to be expressed in other cells. Likewise, it has become clear that some proteins previously thought to be specific to the neutrophil are expressed in epithelial cells during inflammation.}},
author = {{Borregaard, Niels and Sørensen, Ole E and Theilgaard-Wnchl, Kim}},
issn = {{1471-4981}},
language = {{eng}},
number = {{8}},
pages = {{340--345}},
publisher = {{Elsevier}},
series = {{Trends in Immunology}},
title = {{Neutrophil granules: a library of innate immunity proteins}},
url = {{http://dx.doi.org/10.1016/j.it.2007.06.002}},
doi = {{10.1016/j.it.2007.06.002}},
volume = {{28}},
year = {{2007}},
}