Glymphatic pathways in the gyrencephalic brain
(2021) In Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism- Abstract
- Identification of the perivascular compartment as the point of exchange between cerebrospinal fluid (CSF) and interstitial fluid mediating solute clearance in the brain, named the glymphatic system, has emerged as an important clearance pathway for neurotoxic peptides such as amyloid-beta. However, the foundational science of the glymphatic system is based on rodent studies. Here we investigated whether the glymphatic system exists in a large mammal with a highly gyrified brain. CSF penetration into the brain via perivascular pathways, a hallmark of glymphatic function, was seen throughout the gyrencephalic cortex and subcortical structures, validating the conservation of the glymphatic system in a large mammal. Macroscopic CSF tracer... (More)
- Identification of the perivascular compartment as the point of exchange between cerebrospinal fluid (CSF) and interstitial fluid mediating solute clearance in the brain, named the glymphatic system, has emerged as an important clearance pathway for neurotoxic peptides such as amyloid-beta. However, the foundational science of the glymphatic system is based on rodent studies. Here we investigated whether the glymphatic system exists in a large mammal with a highly gyrified brain. CSF penetration into the brain via perivascular pathways, a hallmark of glymphatic function, was seen throughout the gyrencephalic cortex and subcortical structures, validating the conservation of the glymphatic system in a large mammal. Macroscopic CSF tracer distribution followed the sulci and fissures showing that these folds enhance CSF dispersion. Three-dimensional renditions from light sheet microscopy showed a PVS influx density 4-fold larger in the pig brain than in mice. This demonstrates the existence of an advanced solute transport system in the gyrencephalic brain that could be utilised therapeutically for enhancing waste clearance. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/68a913cf-108e-4ba8-9b06-92b64c4b8097
- author
- Bèchet, Nicholas Burdon LU ; Shanbhag, Nagesh C LU and Lundgaard, Iben LU
- organization
- publishing date
- 2021-02-27
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:33641515
- scopus:85101804469
- ISSN
- 1559-7016
- DOI
- 10.1177/0271678X21996175
- language
- English
- LU publication?
- yes
- id
- 68a913cf-108e-4ba8-9b06-92b64c4b8097
- date added to LUP
- 2021-03-19 17:44:35
- date last changed
- 2022-05-12 19:01:38
@article{68a913cf-108e-4ba8-9b06-92b64c4b8097,
abstract = {{Identification of the perivascular compartment as the point of exchange between cerebrospinal fluid (CSF) and interstitial fluid mediating solute clearance in the brain, named the glymphatic system, has emerged as an important clearance pathway for neurotoxic peptides such as amyloid-beta. However, the foundational science of the glymphatic system is based on rodent studies. Here we investigated whether the glymphatic system exists in a large mammal with a highly gyrified brain. CSF penetration into the brain via perivascular pathways, a hallmark of glymphatic function, was seen throughout the gyrencephalic cortex and subcortical structures, validating the conservation of the glymphatic system in a large mammal. Macroscopic CSF tracer distribution followed the sulci and fissures showing that these folds enhance CSF dispersion. Three-dimensional renditions from light sheet microscopy showed a PVS influx density 4-fold larger in the pig brain than in mice. This demonstrates the existence of an advanced solute transport system in the gyrencephalic brain that could be utilised therapeutically for enhancing waste clearance.}},
author = {{Bèchet, Nicholas Burdon and Shanbhag, Nagesh C and Lundgaard, Iben}},
issn = {{1559-7016}},
language = {{eng}},
month = {{02}},
publisher = {{Nature Publishing Group}},
series = {{Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism}},
title = {{Glymphatic pathways in the gyrencephalic brain}},
url = {{http://dx.doi.org/10.1177/0271678X21996175}},
doi = {{10.1177/0271678X21996175}},
year = {{2021}},
}