Adventures on the Routes of Protein Evolution-In Memoriam Dan Salah Tawfik (1955-2021)
Jackson, Colin ; Toth-Petroczy, Agnes ; Kolodny, Rachel ; Hollfelder, Florian ; Fuxreiter, Monika ; Kamerlin, Shina Caroline Lynn LU
and Tokuriki, Nobuhiko
(2022)
In Journal of Molecular Biology
434(7).
- Abstract
Understanding how proteins evolved not only resolves mysteries of the past, but also helps address challenges of the future, particularly those relating to the design and engineering of new protein functions. Here we review the work of Dan S. Tawfik, one of the pioneers of this area, highlighting his seminal contributions in diverse fields such as protein design, high throughput screening, protein stability, fundamental enzyme-catalyzed reactions and promiscuity, that underpin biology and the origins of life. We discuss the influence of his work on how our models of enzyme and protein function have developed and how the main driving forces of molecular evolution were elucidated. The discovery of the rugged routes of evolution has... (More)
Understanding how proteins evolved not only resolves mysteries of the past, but also helps address challenges of the future, particularly those relating to the design and engineering of new protein functions. Here we review the work of Dan S. Tawfik, one of the pioneers of this area, highlighting his seminal contributions in diverse fields such as protein design, high throughput screening, protein stability, fundamental enzyme-catalyzed reactions and promiscuity, that underpin biology and the origins of life. We discuss the influence of his work on how our models of enzyme and protein function have developed and how the main driving forces of molecular evolution were elucidated. The discovery of the rugged routes of evolution has enabled many practical applications, some which are now widely used.
(Less)
- author
- Jackson, Colin
; Toth-Petroczy, Agnes
; Kolodny, Rachel
; Hollfelder, Florian
; Fuxreiter, Monika
; Kamerlin, Shina Caroline Lynn
LU
and Tokuriki, Nobuhiko
- publishing date
- 2022-04-15
- type
- Contribution to journal
- publication status
- published
- keywords
- Catalysis, Directed Molecular Evolution, Enzymes, Evolution, Molecular, High-Throughput Screening Assays, Proteins
- in
- Journal of Molecular Biology
- volume
- 434
- issue
- 7
- article number
- 167462
- publisher
- Elsevier
- external identifiers
-
- scopus:85135147336
- pmid:35104498
- ISSN
- 1089-8638
- DOI
- 10.1016/j.jmb.2022.167462
- language
- English
- LU publication?
- no
- additional info
- Copyright © 2022 Elsevier Ltd. All rights reserved.
- id
- 69054440-9d30-4854-bf80-813948088bdb
- date added to LUP
- 2025-01-11 18:48:27
- date last changed
- 2025-06-01 15:05:47
@article{69054440-9d30-4854-bf80-813948088bdb,
abstract = {{<p>Understanding how proteins evolved not only resolves mysteries of the past, but also helps address challenges of the future, particularly those relating to the design and engineering of new protein functions. Here we review the work of Dan S. Tawfik, one of the pioneers of this area, highlighting his seminal contributions in diverse fields such as protein design, high throughput screening, protein stability, fundamental enzyme-catalyzed reactions and promiscuity, that underpin biology and the origins of life. We discuss the influence of his work on how our models of enzyme and protein function have developed and how the main driving forces of molecular evolution were elucidated. The discovery of the rugged routes of evolution has enabled many practical applications, some which are now widely used.</p>}},
author = {{Jackson, Colin and Toth-Petroczy, Agnes and Kolodny, Rachel and Hollfelder, Florian and Fuxreiter, Monika and Kamerlin, Shina Caroline Lynn and Tokuriki, Nobuhiko}},
issn = {{1089-8638}},
keywords = {{Catalysis; Directed Molecular Evolution; Enzymes; Evolution, Molecular; High-Throughput Screening Assays; Proteins}},
language = {{eng}},
month = {{04}},
number = {{7}},
publisher = {{Elsevier}},
series = {{Journal of Molecular Biology}},
title = {{Adventures on the Routes of Protein Evolution-In Memoriam Dan Salah Tawfik (1955-2021)}},
url = {{http://dx.doi.org/10.1016/j.jmb.2022.167462}},
doi = {{10.1016/j.jmb.2022.167462}},
volume = {{434}},
year = {{2022}},
}