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Diagnostic challenges in patients with reninomas and extrarenal renin-producing tumours

Fabian, Botond ; Ragnarsson, Oskar ; Prazic, Aleksandar LU ; Rydén, Mikael ; Volpe, Cristina and Lindgren, Ola LU (2024) In Clinical Endocrinology
Abstract

Renin-secreting tumours are rare causes of secondary hypertension and hypokalaemia. They are usually surgically curable, hence proper diagnostic work-up and tumour localisation is essential. In this paper, we present three Swedish patients recently diagnosed with renin secreting tumours, two with reninomas and one with an extrarenal renin-producing tumour, to illustrate diagnostic challenges. We also discuss the biochemical work-up, the pros and cons of different imaging techniques (computer tomography [CT], magnetic resonance imaging and [18F]fluorodeoxyglucose-positron emission tomography-CT), as well as how renal vein sampling (RVC) may contribute to localisation of the tumour.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
in press
subject
keywords
aldosterone, extrarenal renin-production, juxtaglomerular cell tumour, renal vein catheterisation, renin, reninoma, secondary hypertension
in
Clinical Endocrinology
publisher
Wiley-Blackwell
external identifiers
  • pmid:38696530
  • scopus:85192174029
ISSN
0300-0664
DOI
10.1111/cen.15069
language
English
LU publication?
yes
id
690a4f66-2651-4c5a-ab79-d8b506020ed8
date added to LUP
2024-05-14 15:34:00
date last changed
2024-06-25 20:04:32
@article{690a4f66-2651-4c5a-ab79-d8b506020ed8,
  abstract     = {{<p>Renin-secreting tumours are rare causes of secondary hypertension and hypokalaemia. They are usually surgically curable, hence proper diagnostic work-up and tumour localisation is essential. In this paper, we present three Swedish patients recently diagnosed with renin secreting tumours, two with reninomas and one with an extrarenal renin-producing tumour, to illustrate diagnostic challenges. We also discuss the biochemical work-up, the pros and cons of different imaging techniques (computer tomography [CT], magnetic resonance imaging and [18F]fluorodeoxyglucose-positron emission tomography-CT), as well as how renal vein sampling (RVC) may contribute to localisation of the tumour.</p>}},
  author       = {{Fabian, Botond and Ragnarsson, Oskar and Prazic, Aleksandar and Rydén, Mikael and Volpe, Cristina and Lindgren, Ola}},
  issn         = {{0300-0664}},
  keywords     = {{aldosterone; extrarenal renin-production; juxtaglomerular cell tumour; renal vein catheterisation; renin; reninoma; secondary hypertension}},
  language     = {{eng}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Clinical Endocrinology}},
  title        = {{Diagnostic challenges in patients with reninomas and extrarenal renin-producing tumours}},
  url          = {{http://dx.doi.org/10.1111/cen.15069}},
  doi          = {{10.1111/cen.15069}},
  year         = {{2024}},
}