Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation
(2018) In Dalton Transactions 47(16). p.5548-5552- Abstract
- Ormaplatin ([Pt(dach)Cl4]) represents one of the three primary structural prototypes of Pt(IV) anticancer-active prodrugs. The reduction of ormaplatin by an extended series of thiols has been studied kinetically in a broad pH range. A novel and remarkable correlation between logkRS− and the thiol dissociation constants pKRSH is disclosed: logkRS− = (0.50 ± 0.02)pKRSH + (0.68 ± 0.13), where kRS− denotes the second-order rate constant of each thiolate towards the reduction of ormaplatin.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/6913db70-66a0-4f0a-8f9f-119ef677e6c5
- author
- Dong, Jingran ; Tian, Hongwu ; Song, Changying ; Shi, Tiesheng and Elding, Lars Ivar LU
- organization
- publishing date
- 2018-03-27
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Ormaplatin, Thiols, Reduction, Kinetics, Mechanism, Anti-cancer drug, Brönsted correlation, Linear free energy correlation
- in
- Dalton Transactions
- volume
- 47
- issue
- 16
- pages
- 5 pages
- publisher
- Royal Society of Chemistry
- external identifiers
-
- pmid:29611592
- scopus:85045947996
- ISSN
- 1477-9234
- DOI
- 10.1039/c8dt00852c
- language
- English
- LU publication?
- yes
- id
- 6913db70-66a0-4f0a-8f9f-119ef677e6c5
- date added to LUP
- 2018-04-16 18:55:42
- date last changed
- 2022-04-25 06:53:24
@article{6913db70-66a0-4f0a-8f9f-119ef677e6c5, abstract = {{Ormaplatin ([Pt(dach)Cl4]) represents one of the three primary structural prototypes of Pt(IV) anticancer-active prodrugs. The reduction of ormaplatin by an extended series of thiols has been studied kinetically in a broad pH range. A novel and remarkable correlation between logkRS− and the thiol dissociation constants pKRSH is disclosed: logkRS− = (0.50 ± 0.02)pKRSH + (0.68 ± 0.13), where kRS− denotes the second-order rate constant of each thiolate towards the reduction of ormaplatin.}}, author = {{Dong, Jingran and Tian, Hongwu and Song, Changying and Shi, Tiesheng and Elding, Lars Ivar}}, issn = {{1477-9234}}, keywords = {{Ormaplatin; Thiols; Reduction; Kinetics; Mechanism; Anti-cancer drug; Brönsted correlation; Linear free energy correlation}}, language = {{eng}}, month = {{03}}, number = {{16}}, pages = {{5548--5552}}, publisher = {{Royal Society of Chemistry}}, series = {{Dalton Transactions}}, title = {{Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation}}, url = {{http://dx.doi.org/10.1039/c8dt00852c}}, doi = {{10.1039/c8dt00852c}}, volume = {{47}}, year = {{2018}}, }