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Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation

Dong, Jingran; Tian, Hongwu; Song, Changying; Shi, Tiesheng and Elding, Lars Ivar LU (2018) In Dalton Transactions 47(16). p.5548-5552
Abstract
Ormaplatin ([Pt(dach)Cl4]) represents one of the three primary structural prototypes of Pt(IV) anticancer-active prodrugs. The reduction of ormaplatin by an extended series of thiols has been studied kinetically in a broad pH range. A novel and remarkable correlation between logkRS− and the thiol dissociation constants pKRSH is disclosed: logkRS− = (0.50 ± 0.02)pKRSH + (0.68 ± 0.13), where kRS− denotes the second-order rate constant of each thiolate towards the reduction of ormaplatin.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ormaplatin , Thiols, Reduction, Kinetics, Mechanism, Anti-cancer drug, Brönsted correlation, Linear free energy correlation
in
Dalton Transactions
volume
47
issue
16
pages
5 pages
publisher
Royal Society of Chemistry
external identifiers
  • scopus:85045947996
ISSN
1477-9234
DOI
10.1039/c8dt00852c
language
English
LU publication?
yes
id
6913db70-66a0-4f0a-8f9f-119ef677e6c5
date added to LUP
2018-04-16 18:55:42
date last changed
2019-03-19 03:53:07
@article{6913db70-66a0-4f0a-8f9f-119ef677e6c5,
  abstract     = {Ormaplatin ([Pt(dach)Cl4]) represents one of the three primary structural prototypes of Pt(IV) anticancer-active prodrugs. The reduction of ormaplatin by an extended series of thiols has been studied kinetically in a broad pH range. A novel and remarkable correlation between logkRS− and the thiol dissociation constants pKRSH is disclosed: logkRS− = (0.50 ± 0.02)pKRSH + (0.68 ± 0.13), where kRS− denotes the second-order rate constant of each thiolate towards the reduction of ormaplatin.},
  author       = {Dong, Jingran and Tian, Hongwu and Song, Changying and Shi, Tiesheng  and Elding, Lars Ivar},
  issn         = {1477-9234},
  keyword      = {Ormaplatin ,Thiols,Reduction,Kinetics,Mechanism,Anti-cancer drug,Brönsted correlation,Linear free energy correlation},
  language     = {eng},
  month        = {03},
  number       = {16},
  pages        = {5548--5552},
  publisher    = {Royal Society of Chemistry},
  series       = {Dalton Transactions},
  title        = {Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation},
  url          = {http://dx.doi.org/10.1039/c8dt00852c},
  volume       = {47},
  year         = {2018},
}