Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis.
(2007) In Circulation 115(4). p.459-467- Abstract
- Background— Carotid intima-media thickness (IMT) is increasingly used as a surrogate marker for atherosclerosis. Its use relies on its ability to predict future clinical cardiovascular end points. We performed a systematic review and meta-analysis of data to examine this association.
Methods and Results— Using a prespecified search strategy, we identified 8 relevant studies and compared study design, measurement protocols, and reported data. We identified sources of heterogeneity between studies. The assumption of a linear relationship between IMT and risk was challenged by use of a graphical technique. To obtain a pooled estimate of the relative risk per IMT difference, we performed a meta-analysis based on random... (More) - Background— Carotid intima-media thickness (IMT) is increasingly used as a surrogate marker for atherosclerosis. Its use relies on its ability to predict future clinical cardiovascular end points. We performed a systematic review and meta-analysis of data to examine this association.
Methods and Results— Using a prespecified search strategy, we identified 8 relevant studies and compared study design, measurement protocols, and reported data. We identified sources of heterogeneity between studies. The assumption of a linear relationship between IMT and risk was challenged by use of a graphical technique. To obtain a pooled estimate of the relative risk per IMT difference, we performed a meta-analysis based on random effects models. The age- and sex-adjusted overall estimates of the relative risk of myocardial infarction were 1.26 (95% CI, 1.21 to 1.30) per 1–standard deviation common carotid artery IMT difference and 1.15 (95% CI, 1.12 to 1.17) per 0.10-mm common carotid artery IMT difference. The age- and sex-adjusted relative risks of stroke were 1.32 (95% CI, 1.27 to 1.38) per 1–standard deviation common carotid artery IMT difference and 1.18 (95% CI, 1.16 to 1.21) per 0.10-mm common carotid artery IMT difference. Major sources of heterogeneity were age distribution, carotid segment definition, and IMT measurement protocol. The relationship between IMT and risk was nonlinear, but the linear models fitted relatively well for moderate to high IMT values.
Conclusions— Carotid IMT is a strong predictor of future vascular events. The relative risk per IMT difference is slightly higher for the end point stroke than for myocardial infarction. In future IMT studies, ultrasound protocols should be aligned with published studies. Data for younger individuals are limited and more studies are required. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/164704
- author
- Lorenz, Matthias W ; Markus, Hugh S ; Bots, Michiel L ; Rosvall, Maria LU and Sitzer, Matthias
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- myocardial infarction, atherosclerosis, meta-analysis, stroke, carotid arteries
- in
- Circulation
- volume
- 115
- issue
- 4
- pages
- 459 - 467
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000243853400009
- scopus:33846609195
- ISSN
- 1524-4539
- DOI
- 10.1161/CIRCULATIONAHA.106.628875
- language
- English
- LU publication?
- yes
- id
- 6917c006-6952-4d15-b954-af24867ea048 (old id 164704)
- date added to LUP
- 2016-04-01 16:00:06
- date last changed
- 2022-05-08 06:31:00
@article{6917c006-6952-4d15-b954-af24867ea048,
abstract = {{Background— Carotid intima-media thickness (IMT) is increasingly used as a surrogate marker for atherosclerosis. Its use relies on its ability to predict future clinical cardiovascular end points. We performed a systematic review and meta-analysis of data to examine this association.<br/><br>
<br/><br>
Methods and Results— Using a prespecified search strategy, we identified 8 relevant studies and compared study design, measurement protocols, and reported data. We identified sources of heterogeneity between studies. The assumption of a linear relationship between IMT and risk was challenged by use of a graphical technique. To obtain a pooled estimate of the relative risk per IMT difference, we performed a meta-analysis based on random effects models. The age- and sex-adjusted overall estimates of the relative risk of myocardial infarction were 1.26 (95% CI, 1.21 to 1.30) per 1–standard deviation common carotid artery IMT difference and 1.15 (95% CI, 1.12 to 1.17) per 0.10-mm common carotid artery IMT difference. The age- and sex-adjusted relative risks of stroke were 1.32 (95% CI, 1.27 to 1.38) per 1–standard deviation common carotid artery IMT difference and 1.18 (95% CI, 1.16 to 1.21) per 0.10-mm common carotid artery IMT difference. Major sources of heterogeneity were age distribution, carotid segment definition, and IMT measurement protocol. The relationship between IMT and risk was nonlinear, but the linear models fitted relatively well for moderate to high IMT values.<br/><br>
<br/><br>
Conclusions— Carotid IMT is a strong predictor of future vascular events. The relative risk per IMT difference is slightly higher for the end point stroke than for myocardial infarction. In future IMT studies, ultrasound protocols should be aligned with published studies. Data for younger individuals are limited and more studies are required.}},
author = {{Lorenz, Matthias W and Markus, Hugh S and Bots, Michiel L and Rosvall, Maria and Sitzer, Matthias}},
issn = {{1524-4539}},
keywords = {{myocardial infarction; atherosclerosis; meta-analysis; stroke; carotid arteries}},
language = {{eng}},
number = {{4}},
pages = {{459--467}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Circulation}},
title = {{Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis.}},
url = {{http://dx.doi.org/10.1161/CIRCULATIONAHA.106.628875}},
doi = {{10.1161/CIRCULATIONAHA.106.628875}},
volume = {{115}},
year = {{2007}},
}