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A Review of the Combination of Experimental Measurements and Fibril-Reinforced Modeling for Investigation of Articular Cartilage and Chondrocyte Response to Loading

Julkunen, Petro; Wilson, Wouter; Isaksson, Hanna LU ; Jurvelin, Jukka S.; Herzog, Walter and Korhonen, Rami K. (2013) In Computational & Mathematical Methods in Medicine
Abstract
The function of articular cartilage depends on its structure and composition, sensitively impaired in disease (e. g. osteoarthritis, OA). Responses of chondrocytes to tissue loading are modulated by the structure. Altered cell responses as an effect of OA may regulate cartilage mechanotransduction and cell biosynthesis. To be able to evaluate cell responses and factors affecting the onset and progression of OA, local tissue and cell stresses and strains in cartilage need to be characterized. This is extremely challenging with the presently available experimental techniques and therefore computational modeling is required. Modern models of articular cartilage are inhomogeneous and anisotropic, and they include many aspects of the real... (More)
The function of articular cartilage depends on its structure and composition, sensitively impaired in disease (e. g. osteoarthritis, OA). Responses of chondrocytes to tissue loading are modulated by the structure. Altered cell responses as an effect of OA may regulate cartilage mechanotransduction and cell biosynthesis. To be able to evaluate cell responses and factors affecting the onset and progression of OA, local tissue and cell stresses and strains in cartilage need to be characterized. This is extremely challenging with the presently available experimental techniques and therefore computational modeling is required. Modern models of articular cartilage are inhomogeneous and anisotropic, and they include many aspects of the real tissue structure and composition. In this paper, we provide an overview of the computational applications that have been developed for modeling the mechanics of articular cartilage at the tissue and cellular level. We concentrate on the use of fibril-reinforced models of cartilage. Furthermore, we introduce practical considerations for modeling applications, including also experimental tests that can be combined with the modeling approach. At the end, we discuss the prospects for patient-specific models when aiming to use finite element modeling analysis and evaluation of articular cartilage function, cellular responses, failure points, OA progression, and rehabilitation. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Computational & Mathematical Methods in Medicine
publisher
Hindawi Publishing Corporation
external identifiers
  • wos:000317775400001
  • scopus:84877283509
ISSN
1748-6718
DOI
10.1155/2013/326150
language
English
LU publication?
yes
id
6920ab89-abeb-4fe7-a2ef-910d8ea2b88e (old id 3857800)
date added to LUP
2013-06-19 12:47:44
date last changed
2019-03-12 01:24:52
@article{6920ab89-abeb-4fe7-a2ef-910d8ea2b88e,
  abstract     = {The function of articular cartilage depends on its structure and composition, sensitively impaired in disease (e. g. osteoarthritis, OA). Responses of chondrocytes to tissue loading are modulated by the structure. Altered cell responses as an effect of OA may regulate cartilage mechanotransduction and cell biosynthesis. To be able to evaluate cell responses and factors affecting the onset and progression of OA, local tissue and cell stresses and strains in cartilage need to be characterized. This is extremely challenging with the presently available experimental techniques and therefore computational modeling is required. Modern models of articular cartilage are inhomogeneous and anisotropic, and they include many aspects of the real tissue structure and composition. In this paper, we provide an overview of the computational applications that have been developed for modeling the mechanics of articular cartilage at the tissue and cellular level. We concentrate on the use of fibril-reinforced models of cartilage. Furthermore, we introduce practical considerations for modeling applications, including also experimental tests that can be combined with the modeling approach. At the end, we discuss the prospects for patient-specific models when aiming to use finite element modeling analysis and evaluation of articular cartilage function, cellular responses, failure points, OA progression, and rehabilitation.},
  articleno    = {326150},
  author       = {Julkunen, Petro and Wilson, Wouter and Isaksson, Hanna and Jurvelin, Jukka S. and Herzog, Walter and Korhonen, Rami K.},
  issn         = {1748-6718},
  language     = {eng},
  publisher    = {Hindawi Publishing Corporation},
  series       = {Computational & Mathematical Methods in Medicine},
  title        = {A Review of the Combination of Experimental Measurements and Fibril-Reinforced Modeling for Investigation of Articular Cartilage and Chondrocyte Response to Loading},
  url          = {http://dx.doi.org/10.1155/2013/326150},
  year         = {2013},
}