Chemokine receptor expression defines heterogeneity in the earliest thymic migrants
(2007) In European Journal of Immunology 37(8). p.2090-2096- Abstract
- Chemokine signaling has been implicated in directing colonization of the fetal thymus by hematopoietic precursors. However, the patterns of expression of the chemokine receptors responsible for directing thymic colonization by the earliest thymic migrants remain unknown. We have identified heterogeneity within the earliest thymus seeding cells based on chemokine receptor expression. By analyzing the first wave of progenitors to colonize the thymus at E12 of gestation, we show that multiple chemokine receptors are expressed by T-lymphoid precursors present within perithymic mesenchyme, while expression of chemokine ligands is limited to CCL21, CCL25 and CXCL12, which are located in distinct epithelial and mesenchymal compartments of the... (More)
- Chemokine signaling has been implicated in directing colonization of the fetal thymus by hematopoietic precursors. However, the patterns of expression of the chemokine receptors responsible for directing thymic colonization by the earliest thymic migrants remain unknown. We have identified heterogeneity within the earliest thymus seeding cells based on chemokine receptor expression. By analyzing the first wave of progenitors to colonize the thymus at E12 of gestation, we show that multiple chemokine receptors are expressed by T-lymphoid precursors present within perithymic mesenchyme, while expression of chemokine ligands is limited to CCL21, CCL25 and CXCL12, which are located in distinct epithelial and mesenchymal compartments of the thymic/parathyroid anlagen. Collectively, these results identify multiple populations of T-lymphoid precursors colonizing the fetal thymus and provide evidence for several potential pathways mediating migration of precursors into the embryonic thymus. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/692645
- author
- Jenkinson, William E. ; Rossi, Simona W. ; Parnell, Sonia ; Agace, William LU ; Takahama, Yousuke ; Jenkinson, Eric J. and Anderson, Graham
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- chemokine receptor, colonization, T cell, thymus
- in
- European Journal of Immunology
- volume
- 37
- issue
- 8
- pages
- 2090 - 2096
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000248936000005
- scopus:34547895468
- ISSN
- 1521-4141
- DOI
- 10.1002/eji.200737212
- language
- English
- LU publication?
- yes
- id
- f1866e6f-6606-44f2-8e2e-6eaaa039d329 (old id 692645)
- date added to LUP
- 2016-04-01 12:24:56
- date last changed
- 2022-01-27 03:27:24
@article{f1866e6f-6606-44f2-8e2e-6eaaa039d329,
abstract = {{Chemokine signaling has been implicated in directing colonization of the fetal thymus by hematopoietic precursors. However, the patterns of expression of the chemokine receptors responsible for directing thymic colonization by the earliest thymic migrants remain unknown. We have identified heterogeneity within the earliest thymus seeding cells based on chemokine receptor expression. By analyzing the first wave of progenitors to colonize the thymus at E12 of gestation, we show that multiple chemokine receptors are expressed by T-lymphoid precursors present within perithymic mesenchyme, while expression of chemokine ligands is limited to CCL21, CCL25 and CXCL12, which are located in distinct epithelial and mesenchymal compartments of the thymic/parathyroid anlagen. Collectively, these results identify multiple populations of T-lymphoid precursors colonizing the fetal thymus and provide evidence for several potential pathways mediating migration of precursors into the embryonic thymus.}},
author = {{Jenkinson, William E. and Rossi, Simona W. and Parnell, Sonia and Agace, William and Takahama, Yousuke and Jenkinson, Eric J. and Anderson, Graham}},
issn = {{1521-4141}},
keywords = {{chemokine receptor; colonization; T cell; thymus}},
language = {{eng}},
number = {{8}},
pages = {{2090--2096}},
publisher = {{John Wiley & Sons Inc.}},
series = {{European Journal of Immunology}},
title = {{Chemokine receptor expression defines heterogeneity in the earliest thymic migrants}},
url = {{http://dx.doi.org/10.1002/eji.200737212}},
doi = {{10.1002/eji.200737212}},
volume = {{37}},
year = {{2007}},
}