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Chemokine receptor expression defines heterogeneity in the earliest thymic migrants

Jenkinson, William E.; Rossi, Simona W.; Parnell, Sonia; Agace, William LU ; Takahama, Yousuke; Jenkinson, Eric J. and Anderson, Graham (2007) In European Journal of Immunology 37(8). p.2090-2096
Abstract
Chemokine signaling has been implicated in directing colonization of the fetal thymus by hematopoietic precursors. However, the patterns of expression of the chemokine receptors responsible for directing thymic colonization by the earliest thymic migrants remain unknown. We have identified heterogeneity within the earliest thymus seeding cells based on chemokine receptor expression. By analyzing the first wave of progenitors to colonize the thymus at E12 of gestation, we show that multiple chemokine receptors are expressed by T-lymphoid precursors present within perithymic mesenchyme, while expression of chemokine ligands is limited to CCL21, CCL25 and CXCL12, which are located in distinct epithelial and mesenchymal compartments of the... (More)
Chemokine signaling has been implicated in directing colonization of the fetal thymus by hematopoietic precursors. However, the patterns of expression of the chemokine receptors responsible for directing thymic colonization by the earliest thymic migrants remain unknown. We have identified heterogeneity within the earliest thymus seeding cells based on chemokine receptor expression. By analyzing the first wave of progenitors to colonize the thymus at E12 of gestation, we show that multiple chemokine receptors are expressed by T-lymphoid precursors present within perithymic mesenchyme, while expression of chemokine ligands is limited to CCL21, CCL25 and CXCL12, which are located in distinct epithelial and mesenchymal compartments of the thymic/parathyroid anlagen. Collectively, these results identify multiple populations of T-lymphoid precursors colonizing the fetal thymus and provide evidence for several potential pathways mediating migration of precursors into the embryonic thymus. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
chemokine receptor, colonization, T cell, thymus
in
European Journal of Immunology
volume
37
issue
8
pages
2090 - 2096
publisher
John Wiley & Sons
external identifiers
  • wos:000248936000005
  • scopus:34547895468
ISSN
1521-4141
DOI
10.1002/eji.200737212
language
English
LU publication?
yes
id
f1866e6f-6606-44f2-8e2e-6eaaa039d329 (old id 692645)
date added to LUP
2007-12-13 10:36:40
date last changed
2017-05-28 03:46:27
@article{f1866e6f-6606-44f2-8e2e-6eaaa039d329,
  abstract     = {Chemokine signaling has been implicated in directing colonization of the fetal thymus by hematopoietic precursors. However, the patterns of expression of the chemokine receptors responsible for directing thymic colonization by the earliest thymic migrants remain unknown. We have identified heterogeneity within the earliest thymus seeding cells based on chemokine receptor expression. By analyzing the first wave of progenitors to colonize the thymus at E12 of gestation, we show that multiple chemokine receptors are expressed by T-lymphoid precursors present within perithymic mesenchyme, while expression of chemokine ligands is limited to CCL21, CCL25 and CXCL12, which are located in distinct epithelial and mesenchymal compartments of the thymic/parathyroid anlagen. Collectively, these results identify multiple populations of T-lymphoid precursors colonizing the fetal thymus and provide evidence for several potential pathways mediating migration of precursors into the embryonic thymus.},
  author       = {Jenkinson, William E. and Rossi, Simona W. and Parnell, Sonia and Agace, William and Takahama, Yousuke and Jenkinson, Eric J. and Anderson, Graham},
  issn         = {1521-4141},
  keyword      = {chemokine receptor,colonization,T cell,thymus},
  language     = {eng},
  number       = {8},
  pages        = {2090--2096},
  publisher    = {John Wiley & Sons},
  series       = {European Journal of Immunology},
  title        = {Chemokine receptor expression defines heterogeneity in the earliest thymic migrants},
  url          = {http://dx.doi.org/10.1002/eji.200737212},
  volume       = {37},
  year         = {2007},
}