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Napsin A (TA02) is a useful alternative to thyroid transcription factor-1 (TTF-1) for the identification of pulmonary adenocarcinoma cells in pleural effusions

Dejmek, Annika LU ; Naucler, Pontus LU ; Smedjeback, Anita; Kato, Harubumi; Maeda, Masahiro; Yashima, Koichi; Maeda, Junichi and Hirano, Takashi (2007) In Diagnostic Cytopathology 35(8). p.493-497
Abstract
The purpose of this study was to test napsin A as a diagnostic marker of metastatic lung adenocarcinoma in pleural effusions, and to compare its performance with TTF-1. Napsin A and TTF-1 reactivities were determined immunohistochemically on.formalin-fixed paraffin embedded cell blocks from 50 pleural effusion (5 mesotheliomas, 10 mesothelial proliferations, 12 pulmonary, and 23 nonpulmonary metastases). The results were evaluated separately, and correlated to the final diagnoses. Concordant results were obtained in 48150 cases. TTF-1 and Napsin A were positive in 8112 and 10112 pulmonary adenocarcinomas, respectively. Both markers were negative in 42 cases, including two lung carcinomas. Napsin reactivity was found in more than 75% of the... (More)
The purpose of this study was to test napsin A as a diagnostic marker of metastatic lung adenocarcinoma in pleural effusions, and to compare its performance with TTF-1. Napsin A and TTF-1 reactivities were determined immunohistochemically on.formalin-fixed paraffin embedded cell blocks from 50 pleural effusion (5 mesotheliomas, 10 mesothelial proliferations, 12 pulmonary, and 23 nonpulmonary metastases). The results were evaluated separately, and correlated to the final diagnoses. Concordant results were obtained in 48150 cases. TTF-1 and Napsin A were positive in 8112 and 10112 pulmonary adenocarcinomas, respectively. Both markers were negative in 42 cases, including two lung carcinomas. Napsin reactivity was found in more than 75% of the tumor cells in 9110 positive cases, whereas TTF-1 reactivity was seen in more than 75% of the tumor cells in 218 positive cases only (P < 0.05). This makes napsin A an alternative to TTF-1 in cytological diagnosis of effusions in which tumor cells may be scanty. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
immunocytochemistry, effusion, adenocarcinoma, lung, Napsin A, TTF-1
in
Diagnostic Cytopathology
volume
35
issue
8
pages
493 - 497
publisher
John Wiley & Sons
external identifiers
  • wos:000248817400006
  • scopus:34547928161
ISSN
8755-1039
DOI
10.1002/dc.20667
language
English
LU publication?
yes
id
b29ae066-fc18-41eb-a8d7-0606f535394a (old id 692715)
date added to LUP
2007-12-07 09:41:34
date last changed
2017-09-10 03:42:16
@article{b29ae066-fc18-41eb-a8d7-0606f535394a,
  abstract     = {The purpose of this study was to test napsin A as a diagnostic marker of metastatic lung adenocarcinoma in pleural effusions, and to compare its performance with TTF-1. Napsin A and TTF-1 reactivities were determined immunohistochemically on.formalin-fixed paraffin embedded cell blocks from 50 pleural effusion (5 mesotheliomas, 10 mesothelial proliferations, 12 pulmonary, and 23 nonpulmonary metastases). The results were evaluated separately, and correlated to the final diagnoses. Concordant results were obtained in 48150 cases. TTF-1 and Napsin A were positive in 8112 and 10112 pulmonary adenocarcinomas, respectively. Both markers were negative in 42 cases, including two lung carcinomas. Napsin reactivity was found in more than 75% of the tumor cells in 9110 positive cases, whereas TTF-1 reactivity was seen in more than 75% of the tumor cells in 218 positive cases only (P &lt; 0.05). This makes napsin A an alternative to TTF-1 in cytological diagnosis of effusions in which tumor cells may be scanty.},
  author       = {Dejmek, Annika and Naucler, Pontus and Smedjeback, Anita and Kato, Harubumi and Maeda, Masahiro and Yashima, Koichi and Maeda, Junichi and Hirano, Takashi},
  issn         = {8755-1039},
  keyword      = {immunocytochemistry,effusion,adenocarcinoma,lung,Napsin A,TTF-1},
  language     = {eng},
  number       = {8},
  pages        = {493--497},
  publisher    = {John Wiley & Sons},
  series       = {Diagnostic Cytopathology},
  title        = {Napsin A (TA02) is a useful alternative to thyroid transcription factor-1 (TTF-1) for the identification of pulmonary adenocarcinoma cells in pleural effusions},
  url          = {http://dx.doi.org/10.1002/dc.20667},
  volume       = {35},
  year         = {2007},
}