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The complex cytological features of synovial sarcoma in fine needle aspirates, an analysis of four illustrative cases

Åkerman, Måns LU and Domanski, Henryk LU (2007) In Cytopathology 18(4). p.234-240
Abstract
Objective: The cytological features of conventional monophasic spindle cell and biphasic synovial sarcoma have been defined in detail in several large series. The cytology of rare morphological variants, especially the subtypes of poorly differentiated synovial sarcoma, are insufficiently evaluated and diagnostically difficult to define. The objective of the present study was to call attention to the variable cytology of rare variants of synovial sarcoma. Furthermore, adjunctive diagnostic methods, necessary for a correct diagnosis, are discussed. Methods: Aspirates from four synovial sarcomas, with cytological features, which differed from those of conventional synovial sarcoma and from each other, were retrieved from our files and... (More)
Objective: The cytological features of conventional monophasic spindle cell and biphasic synovial sarcoma have been defined in detail in several large series. The cytology of rare morphological variants, especially the subtypes of poorly differentiated synovial sarcoma, are insufficiently evaluated and diagnostically difficult to define. The objective of the present study was to call attention to the variable cytology of rare variants of synovial sarcoma. Furthermore, adjunctive diagnostic methods, necessary for a correct diagnosis, are discussed. Methods: Aspirates from four synovial sarcomas, with cytological features, which differed from those of conventional synovial sarcoma and from each other, were retrieved from our files and re-evaluated. Results: In three of the cases a correct diagnosis was not obtained from routinely stained aspirates. In the fourth case, the correct diagnosis was established by a combination of cytomorphology, immunocytochemistry and fluorescence in situ hybridization (FISH) performed on the aspirated material. Conclusion: Ancillary diagnostic methods are necessary in the examination of aspiration smears from synovial sarcoma, especially of morphological variants with a cytomorphology that differs from conventional spindle-cell monophasic and biphasic tumours. Immunocytochemistry and molecular genetic examinations (reverse transcriptase polymerase chain reaction or FISH) are the methods of choice. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
block, immunohistochemistry, fine needle aspiration, synovial sarcoma, cytology, cytodiagnosis cell, molecular genetics synovial sarcoma, fine, needle aspiration, cytodiagnosis cell block, molecular genetics
in
Cytopathology
volume
18
issue
4
pages
234 - 240
publisher
Wiley-Blackwell
external identifiers
  • wos:000248592300005
  • scopus:34447500176
ISSN
1365-2303
DOI
10.1111/j.1365-2303.2007.00458.x
language
English
LU publication?
yes
id
b61811f4-5a47-41e2-89ab-ce0a0a6990f7 (old id 692764)
date added to LUP
2007-12-11 13:32:40
date last changed
2017-08-13 03:31:43
@article{b61811f4-5a47-41e2-89ab-ce0a0a6990f7,
  abstract     = {Objective: The cytological features of conventional monophasic spindle cell and biphasic synovial sarcoma have been defined in detail in several large series. The cytology of rare morphological variants, especially the subtypes of poorly differentiated synovial sarcoma, are insufficiently evaluated and diagnostically difficult to define. The objective of the present study was to call attention to the variable cytology of rare variants of synovial sarcoma. Furthermore, adjunctive diagnostic methods, necessary for a correct diagnosis, are discussed. Methods: Aspirates from four synovial sarcomas, with cytological features, which differed from those of conventional synovial sarcoma and from each other, were retrieved from our files and re-evaluated. Results: In three of the cases a correct diagnosis was not obtained from routinely stained aspirates. In the fourth case, the correct diagnosis was established by a combination of cytomorphology, immunocytochemistry and fluorescence in situ hybridization (FISH) performed on the aspirated material. Conclusion: Ancillary diagnostic methods are necessary in the examination of aspiration smears from synovial sarcoma, especially of morphological variants with a cytomorphology that differs from conventional spindle-cell monophasic and biphasic tumours. Immunocytochemistry and molecular genetic examinations (reverse transcriptase polymerase chain reaction or FISH) are the methods of choice.},
  author       = {Åkerman, Måns and Domanski, Henryk},
  issn         = {1365-2303},
  keyword      = {block,immunohistochemistry,fine needle aspiration,synovial sarcoma,cytology,cytodiagnosis cell,molecular genetics synovial sarcoma,fine,needle aspiration,cytodiagnosis cell block,molecular genetics},
  language     = {eng},
  number       = {4},
  pages        = {234--240},
  publisher    = {Wiley-Blackwell},
  series       = {Cytopathology},
  title        = {The complex cytological features of synovial sarcoma in fine needle aspirates, an analysis of four illustrative cases},
  url          = {http://dx.doi.org/10.1111/j.1365-2303.2007.00458.x},
  volume       = {18},
  year         = {2007},
}