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Active and passive immunization for atherosclerosis

Chyu, Kuang-Yuh; Nilsson, Jan LU and Shah, Prediman K. (2007) In Current Opinion in Molecular Therapeutics 9(2). p.176-182
Abstract
This review summarizes experimental findings that highlight the role of immune mechanisms in atherosclerosis and the potential atheroprotective effects of active or passive immunization strategies. Immunomodulation therapy appears to be feasible and effective, suggesting that a vaccine for atherosclerosis can be developed for clinical testing. Given the increasing number of patients with atherosclerotic disease on current therapy, a new therapy is needed and an immunization strategy could provide such a possibility. Several questions regarding this approach remain unanswered, however, such as choice of optimal antigens, choice of most effective adjuvants, the optimal route of administration, durability of effects and safety, but cautious... (More)
This review summarizes experimental findings that highlight the role of immune mechanisms in atherosclerosis and the potential atheroprotective effects of active or passive immunization strategies. Immunomodulation therapy appears to be feasible and effective, suggesting that a vaccine for atherosclerosis can be developed for clinical testing. Given the increasing number of patients with atherosclerotic disease on current therapy, a new therapy is needed and an immunization strategy could provide such a possibility. Several questions regarding this approach remain unanswered, however, such as choice of optimal antigens, choice of most effective adjuvants, the optimal route of administration, durability of effects and safety, but cautious optimism remains that a vaccine-based approach has the potential to become a part of the armamentarium for atherosclerotic vascular disease. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
immunization, atherosclerosis, immune response, vaccination
in
Current Opinion in Molecular Therapeutics
volume
9
issue
2
pages
176 - 182
publisher
Thomson Reuters
external identifiers
  • wos:000248870700011
  • scopus:34247267297
ISSN
2040-3445
language
English
LU publication?
yes
id
641ea237-d1ac-47b6-8bf7-efb0652db9dc (old id 692767)
alternative location
http://www.biomedcentral.com/content/pdf/cd-780903.pdf
date added to LUP
2007-12-06 10:33:56
date last changed
2017-01-01 05:15:58
@article{641ea237-d1ac-47b6-8bf7-efb0652db9dc,
  abstract     = {This review summarizes experimental findings that highlight the role of immune mechanisms in atherosclerosis and the potential atheroprotective effects of active or passive immunization strategies. Immunomodulation therapy appears to be feasible and effective, suggesting that a vaccine for atherosclerosis can be developed for clinical testing. Given the increasing number of patients with atherosclerotic disease on current therapy, a new therapy is needed and an immunization strategy could provide such a possibility. Several questions regarding this approach remain unanswered, however, such as choice of optimal antigens, choice of most effective adjuvants, the optimal route of administration, durability of effects and safety, but cautious optimism remains that a vaccine-based approach has the potential to become a part of the armamentarium for atherosclerotic vascular disease.},
  author       = {Chyu, Kuang-Yuh and Nilsson, Jan and Shah, Prediman K.},
  issn         = {2040-3445},
  keyword      = {immunization,atherosclerosis,immune response,vaccination},
  language     = {eng},
  number       = {2},
  pages        = {176--182},
  publisher    = {Thomson Reuters},
  series       = {Current Opinion in Molecular Therapeutics},
  title        = {Active and passive immunization for atherosclerosis},
  volume       = {9},
  year         = {2007},
}