Active and passive immunization for atherosclerosis
(2007) In Current Opinion in Molecular Therapeutics 9(2). p.176-182- Abstract
- This review summarizes experimental findings that highlight the role of immune mechanisms in atherosclerosis and the potential atheroprotective effects of active or passive immunization strategies. Immunomodulation therapy appears to be feasible and effective, suggesting that a vaccine for atherosclerosis can be developed for clinical testing. Given the increasing number of patients with atherosclerotic disease on current therapy, a new therapy is needed and an immunization strategy could provide such a possibility. Several questions regarding this approach remain unanswered, however, such as choice of optimal antigens, choice of most effective adjuvants, the optimal route of administration, durability of effects and safety, but cautious... (More)
- This review summarizes experimental findings that highlight the role of immune mechanisms in atherosclerosis and the potential atheroprotective effects of active or passive immunization strategies. Immunomodulation therapy appears to be feasible and effective, suggesting that a vaccine for atherosclerosis can be developed for clinical testing. Given the increasing number of patients with atherosclerotic disease on current therapy, a new therapy is needed and an immunization strategy could provide such a possibility. Several questions regarding this approach remain unanswered, however, such as choice of optimal antigens, choice of most effective adjuvants, the optimal route of administration, durability of effects and safety, but cautious optimism remains that a vaccine-based approach has the potential to become a part of the armamentarium for atherosclerotic vascular disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/692767
- author
- Chyu, Kuang-Yuh ; Nilsson, Jan LU and Shah, Prediman K.
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- immunization, atherosclerosis, immune response, vaccination
- in
- Current Opinion in Molecular Therapeutics
- volume
- 9
- issue
- 2
- pages
- 176 - 182
- publisher
- Thomson Reuters
- external identifiers
-
- wos:000248870700011
- scopus:34247267297
- ISSN
- 2040-3445
- language
- English
- LU publication?
- yes
- id
- 641ea237-d1ac-47b6-8bf7-efb0652db9dc (old id 692767)
- alternative location
- http://www.biomedcentral.com/content/pdf/cd-780903.pdf
- date added to LUP
- 2016-04-01 12:34:32
- date last changed
- 2022-01-27 07:00:39
@article{641ea237-d1ac-47b6-8bf7-efb0652db9dc, abstract = {{This review summarizes experimental findings that highlight the role of immune mechanisms in atherosclerosis and the potential atheroprotective effects of active or passive immunization strategies. Immunomodulation therapy appears to be feasible and effective, suggesting that a vaccine for atherosclerosis can be developed for clinical testing. Given the increasing number of patients with atherosclerotic disease on current therapy, a new therapy is needed and an immunization strategy could provide such a possibility. Several questions regarding this approach remain unanswered, however, such as choice of optimal antigens, choice of most effective adjuvants, the optimal route of administration, durability of effects and safety, but cautious optimism remains that a vaccine-based approach has the potential to become a part of the armamentarium for atherosclerotic vascular disease.}}, author = {{Chyu, Kuang-Yuh and Nilsson, Jan and Shah, Prediman K.}}, issn = {{2040-3445}}, keywords = {{immunization; atherosclerosis; immune response; vaccination}}, language = {{eng}}, number = {{2}}, pages = {{176--182}}, publisher = {{Thomson Reuters}}, series = {{Current Opinion in Molecular Therapeutics}}, title = {{Active and passive immunization for atherosclerosis}}, url = {{http://www.biomedcentral.com/content/pdf/cd-780903.pdf}}, volume = {{9}}, year = {{2007}}, }