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α-l-FucosyItransferases in Human Serum from Donors of Different ABO, Secretor and Lewis Blood-Group Phenotypes

Schenkel-Brunner, Helmut ; Chester, Alan LU and Watkins, Winifred M (1972) In European Journal of Biochemistry 30(2). p.269-277
Abstract
The presence of α-l-fucosyltransferases in human serum of different ABO, secretor and Lewis blood-group phenotypes was investigated with guanosine diphosphate fucose as the sugar donor and low-molecular-weight oligosaccharides, or a macromolecular glycoprotein, as acceptors. In contrast to the α-2-l-fucosyltransferases in human milk, submaxillary glands and stomach mucosa that occur only in ABH secretors, an enzyme that transfers l-fucose to the C-2 position of non-reducing β-galactosyl residues was found in the serum of all normal ABO donors irrespective of their ABH secretor-nonsecretor status. The only sera in which the α-2-l-fucosyltransferase was not demonstrable were three examples of the blood group Bombay Oh phenotype and one... (More)
The presence of α-l-fucosyltransferases in human serum of different ABO, secretor and Lewis blood-group phenotypes was investigated with guanosine diphosphate fucose as the sugar donor and low-molecular-weight oligosaccharides, or a macromolecular glycoprotein, as acceptors. In contrast to the α-2-l-fucosyltransferases in human milk, submaxillary glands and stomach mucosa that occur only in ABH secretors, an enzyme that transfers l-fucose to the C-2 position of non-reducing β-galactosyl residues was found in the serum of all normal ABO donors irrespective of their ABH secretor-nonsecretor status. The only sera in which the α-2-l-fucosyltransferase was not demonstrable were three examples of the blood group Bombay Oh phenotype and one example of the Bh phenotype. An a-3-l-fucosyltransferase that conveyed L-fucose to the C-3 position in N-acetyl-d-glucosamine or d-glucose occurred in all the sera examined including those from donors of the Bombay Oh and Bh phenotypes. a-4-l-Fucosyltransferase activity was virtually absent from the sera, irrespective of the Lewis blood group of the donors. (Less)
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author
; and
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Biochemistry
volume
30
issue
2
pages
269 - 277
publisher
Wiley-Blackwell
external identifiers
  • pmid:4663380
  • scopus:0015406955
ISSN
0014-2956
DOI
10.1111/j.1432-1033.1972.tb02095.x
language
English
LU publication?
no
id
69293be7-86f6-424b-91bb-a53d91b6a7b4 (old id 1102560)
date added to LUP
2016-04-01 15:42:22
date last changed
2025-10-14 13:17:10
@article{69293be7-86f6-424b-91bb-a53d91b6a7b4,
  abstract     = {{The presence of α-l-fucosyltransferases in human serum of different ABO, secretor and Lewis blood-group phenotypes was investigated with guanosine diphosphate fucose as the sugar donor and low-molecular-weight oligosaccharides, or a macromolecular glycoprotein, as acceptors. In contrast to the α-2-l-fucosyltransferases in human milk, submaxillary glands and stomach mucosa that occur only in ABH secretors, an enzyme that transfers l-fucose to the C-2 position of non-reducing β-galactosyl residues was found in the serum of all normal ABO donors irrespective of their ABH secretor-nonsecretor status. The only sera in which the α-2-l-fucosyltransferase was not demonstrable were three examples of the blood group Bombay Oh phenotype and one example of the Bh phenotype. An a-3-l-fucosyltransferase that conveyed L-fucose to the C-3 position in N-acetyl-d-glucosamine or d-glucose occurred in all the sera examined including those from donors of the Bombay Oh and Bh phenotypes. a-4-l-Fucosyltransferase activity was virtually absent from the sera, irrespective of the Lewis blood group of the donors.}},
  author       = {{Schenkel-Brunner, Helmut and Chester, Alan and Watkins, Winifred M}},
  issn         = {{0014-2956}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{269--277}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{European Journal of Biochemistry}},
  title        = {{α-l-FucosyItransferases in Human Serum from Donors of Different ABO, Secretor and Lewis Blood-Group Phenotypes}},
  url          = {{http://dx.doi.org/10.1111/j.1432-1033.1972.tb02095.x}},
  doi          = {{10.1111/j.1432-1033.1972.tb02095.x}},
  volume       = {{30}},
  year         = {{1972}},
}