α-l-FucosyItransferases in Human Serum from Donors of Different ABO, Secretor and Lewis Blood-Group Phenotypes
(1972) In European Journal of Biochemistry 30(2). p.269-277- Abstract
- The presence of α-l-fucosyltransferases in human serum of different ABO, secretor and Lewis blood-group phenotypes was investigated with guanosine diphosphate fucose as the sugar donor and low-molecular-weight oligosaccharides, or a macromolecular glycoprotein, as acceptors. In contrast to the α-2-l-fucosyltransferases in human milk, submaxillary glands and stomach mucosa that occur only in ABH secretors, an enzyme that transfers l-fucose to the C-2 position of non-reducing β-galactosyl residues was found in the serum of all normal ABO donors irrespective of their ABH secretor-nonsecretor status. The only sera in which the α-2-l-fucosyltransferase was not demonstrable were three examples of the blood group Bombay Oh phenotype and one... (More)
- The presence of α-l-fucosyltransferases in human serum of different ABO, secretor and Lewis blood-group phenotypes was investigated with guanosine diphosphate fucose as the sugar donor and low-molecular-weight oligosaccharides, or a macromolecular glycoprotein, as acceptors. In contrast to the α-2-l-fucosyltransferases in human milk, submaxillary glands and stomach mucosa that occur only in ABH secretors, an enzyme that transfers l-fucose to the C-2 position of non-reducing β-galactosyl residues was found in the serum of all normal ABO donors irrespective of their ABH secretor-nonsecretor status. The only sera in which the α-2-l-fucosyltransferase was not demonstrable were three examples of the blood group Bombay Oh phenotype and one example of the Bh phenotype. An a-3-l-fucosyltransferase that conveyed L-fucose to the C-3 position in N-acetyl-d-glucosamine or d-glucose occurred in all the sera examined including those from donors of the Bombay Oh and Bh phenotypes. a-4-l-Fucosyltransferase activity was virtually absent from the sera, irrespective of the Lewis blood group of the donors. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1102560
- author
- Schenkel-Brunner, Helmut ; Chester, Alan LU and Watkins, Winifred M
- publishing date
- 1972
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Biochemistry
- volume
- 30
- issue
- 2
- pages
- 269 - 277
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:4663380
- scopus:0015406955
- ISSN
- 0014-2956
- DOI
- 10.1111/j.1432-1033.1972.tb02095.x
- language
- English
- LU publication?
- no
- id
- 69293be7-86f6-424b-91bb-a53d91b6a7b4 (old id 1102560)
- date added to LUP
- 2016-04-01 15:42:22
- date last changed
- 2021-06-20 04:26:45
@article{69293be7-86f6-424b-91bb-a53d91b6a7b4, abstract = {{The presence of α-l-fucosyltransferases in human serum of different ABO, secretor and Lewis blood-group phenotypes was investigated with guanosine diphosphate fucose as the sugar donor and low-molecular-weight oligosaccharides, or a macromolecular glycoprotein, as acceptors. In contrast to the α-2-l-fucosyltransferases in human milk, submaxillary glands and stomach mucosa that occur only in ABH secretors, an enzyme that transfers l-fucose to the C-2 position of non-reducing β-galactosyl residues was found in the serum of all normal ABO donors irrespective of their ABH secretor-nonsecretor status. The only sera in which the α-2-l-fucosyltransferase was not demonstrable were three examples of the blood group Bombay Oh phenotype and one example of the Bh phenotype. An a-3-l-fucosyltransferase that conveyed L-fucose to the C-3 position in N-acetyl-d-glucosamine or d-glucose occurred in all the sera examined including those from donors of the Bombay Oh and Bh phenotypes. a-4-l-Fucosyltransferase activity was virtually absent from the sera, irrespective of the Lewis blood group of the donors.}}, author = {{Schenkel-Brunner, Helmut and Chester, Alan and Watkins, Winifred M}}, issn = {{0014-2956}}, language = {{eng}}, number = {{2}}, pages = {{269--277}}, publisher = {{Wiley-Blackwell}}, series = {{European Journal of Biochemistry}}, title = {{α-l-FucosyItransferases in Human Serum from Donors of Different ABO, Secretor and Lewis Blood-Group Phenotypes}}, url = {{http://dx.doi.org/10.1111/j.1432-1033.1972.tb02095.x}}, doi = {{10.1111/j.1432-1033.1972.tb02095.x}}, volume = {{30}}, year = {{1972}}, }