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Organic electrochemical neurons and synapses with ion mediated spiking

Harikesh, Padinhare Cholakkal ; Yang, Chi Yuan ; Tu, Deyu ; Gerasimov, Jennifer Y. ; Dar, Abdul Manan ; Armada-Moreira, Adam ; Massetti, Matteo ; Kroon, Renee ; Bliman, David LU and Olsson, Roger LU orcid , et al. (2022) In Nature Communications 13.
Abstract

Future brain-machine interfaces, prosthetics, and intelligent soft robotics will require integrating artificial neuromorphic devices with biological systems. Due to their poor biocompatibility, circuit complexity, low energy efficiency, and operating principles fundamentally different from the ion signal modulation of biology, traditional Silicon-based neuromorphic implementations have limited bio-integration potential. Here, we report the first organic electrochemical neurons (OECNs) with ion-modulated spiking, based on all-printed complementary organic electrochemical transistors. We demonstrate facile bio-integration of OECNs with Venus Flytrap (Dionaea muscipula) to induce lobe closure upon input stimuli. The OECNs can also be... (More)

Future brain-machine interfaces, prosthetics, and intelligent soft robotics will require integrating artificial neuromorphic devices with biological systems. Due to their poor biocompatibility, circuit complexity, low energy efficiency, and operating principles fundamentally different from the ion signal modulation of biology, traditional Silicon-based neuromorphic implementations have limited bio-integration potential. Here, we report the first organic electrochemical neurons (OECNs) with ion-modulated spiking, based on all-printed complementary organic electrochemical transistors. We demonstrate facile bio-integration of OECNs with Venus Flytrap (Dionaea muscipula) to induce lobe closure upon input stimuli. The OECNs can also be integrated with all-printed organic electrochemical synapses (OECSs), exhibiting short-term plasticity with paired-pulse facilitation and long-term plasticity with retention >1000 s, facilitating Hebbian learning. These soft and flexible OECNs operate below 0.6 V and respond to multiple stimuli, defining a new vista for localized artificial neuronal systems possible to integrate with bio-signaling systems of plants, invertebrates, and vertebrates.

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organization
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type
Contribution to journal
publication status
published
subject
in
Nature Communications
volume
13
article number
901 (2022)
publisher
Nature Publishing Group
external identifiers
  • scopus:85125156007
  • pmid:35194026
ISSN
2041-1723
DOI
10.1038/s41467-022-28483-6
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2022, The Author(s).
id
692bc990-63a1-43bf-85ab-d2dfc73c94fe
date added to LUP
2022-03-21 16:56:34
date last changed
2024-06-20 12:15:16
@article{692bc990-63a1-43bf-85ab-d2dfc73c94fe,
  abstract     = {{<p>Future brain-machine interfaces, prosthetics, and intelligent soft robotics will require integrating artificial neuromorphic devices with biological systems. Due to their poor biocompatibility, circuit complexity, low energy efficiency, and operating principles fundamentally different from the ion signal modulation of biology, traditional Silicon-based neuromorphic implementations have limited bio-integration potential. Here, we report the first organic electrochemical neurons (OECNs) with ion-modulated spiking, based on all-printed complementary organic electrochemical transistors. We demonstrate facile bio-integration of OECNs with Venus Flytrap (Dionaea muscipula) to induce lobe closure upon input stimuli. The OECNs can also be integrated with all-printed organic electrochemical synapses (OECSs), exhibiting short-term plasticity with paired-pulse facilitation and long-term plasticity with retention &gt;1000 s, facilitating Hebbian learning. These soft and flexible OECNs operate below 0.6 V and respond to multiple stimuli, defining a new vista for localized artificial neuronal systems possible to integrate with bio-signaling systems of plants, invertebrates, and vertebrates.</p>}},
  author       = {{Harikesh, Padinhare Cholakkal and Yang, Chi Yuan and Tu, Deyu and Gerasimov, Jennifer Y. and Dar, Abdul Manan and Armada-Moreira, Adam and Massetti, Matteo and Kroon, Renee and Bliman, David and Olsson, Roger and Stavrinidou, Eleni and Berggren, Magnus and Fabiano, Simone}},
  issn         = {{2041-1723}},
  language     = {{eng}},
  month        = {{02}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{Organic electrochemical neurons and synapses with ion mediated spiking}},
  url          = {{http://dx.doi.org/10.1038/s41467-022-28483-6}},
  doi          = {{10.1038/s41467-022-28483-6}},
  volume       = {{13}},
  year         = {{2022}},
}