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The Salt-Inducible Kinases : Emerging Metabolic Regulators

Sakamoto, Kei; Bultot, Laurent and Göransson, Olga LU (2018) In Trends in Endocrinology and Metabolism 29(12). p.827-840
Abstract

The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and... (More)

The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
AMP-activated protein kinase, AMPK, AMPK-related kinase, energy metabolism, gluconeogenesis, LKB1
in
Trends in Endocrinology and Metabolism
volume
29
issue
12
pages
827 - 840
publisher
Elsevier
external identifiers
  • scopus:85055532936
ISSN
1043-2760
DOI
10.1016/j.tem.2018.09.007
language
English
LU publication?
yes
id
6930fddd-b22a-4edb-ada6-09d357228c98
date added to LUP
2018-11-19 10:23:20
date last changed
2019-10-15 06:50:42
@article{6930fddd-b22a-4edb-ada6-09d357228c98,
  abstract     = {<p>The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation.</p>},
  author       = {Sakamoto, Kei and Bultot, Laurent and Göransson, Olga},
  issn         = {1043-2760},
  keyword      = {AMP-activated protein kinase,AMPK,AMPK-related kinase,energy metabolism,gluconeogenesis,LKB1},
  language     = {eng},
  number       = {12},
  pages        = {827--840},
  publisher    = {Elsevier},
  series       = {Trends in Endocrinology and Metabolism},
  title        = {The Salt-Inducible Kinases : Emerging Metabolic Regulators},
  url          = {http://dx.doi.org/10.1016/j.tem.2018.09.007},
  volume       = {29},
  year         = {2018},
}