The Salt-Inducible Kinases : Emerging Metabolic Regulators
Sakamoto, Kei ; Bultot, Laurent and Göransson, Olga LU
(2018)
In Trends in Endocrinology and Metabolism
29(12).
p.827-840
- Abstract
The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and... (More)
The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation.
(Less)
- author
- Sakamoto, Kei
; Bultot, Laurent
and Göransson, Olga
LU
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- AMP-activated protein kinase, AMPK, AMPK-related kinase, energy metabolism, gluconeogenesis, LKB1
- in
- Trends in Endocrinology and Metabolism
- volume
- 29
- issue
- 12
- pages
- 827 - 840
- publisher
- Elsevier
- external identifiers
-
- pmid:30385008
- scopus:85055532936
- ISSN
- 1043-2760
- DOI
- 10.1016/j.tem.2018.09.007
- language
- English
- LU publication?
- yes
- id
- 6930fddd-b22a-4edb-ada6-09d357228c98
- date added to LUP
- 2018-11-19 10:23:20
- date last changed
- 2025-05-01 10:13:08
@article{6930fddd-b22a-4edb-ada6-09d357228c98,
abstract = {{<p>The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation.</p>}},
author = {{Sakamoto, Kei and Bultot, Laurent and Göransson, Olga}},
issn = {{1043-2760}},
keywords = {{AMP-activated protein kinase; AMPK; AMPK-related kinase; energy metabolism; gluconeogenesis; LKB1}},
language = {{eng}},
number = {{12}},
pages = {{827--840}},
publisher = {{Elsevier}},
series = {{Trends in Endocrinology and Metabolism}},
title = {{The Salt-Inducible Kinases : Emerging Metabolic Regulators}},
url = {{http://dx.doi.org/10.1016/j.tem.2018.09.007}},
doi = {{10.1016/j.tem.2018.09.007}},
volume = {{29}},
year = {{2018}},
}