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Characterization of the subventricular zone neurogenic response to rat malignant brain tumors

Bexell, Daniel LU ; Gunnarsson, Salina LU ; Nordquist, J. and Bengzon, Johan LU (2007) In Neuroscience 147(3). p.824-832
Abstract
The subventricular zone (SVZ) is one of the neurogenic regions of the adult brain. We characterized the neurogenic response of the SVZ to the growth of brain tumors in the rat striatum. Abundant nestin positive cells, most likely representing reactive astrocytes, were found surrounding the tumor. However, we observed no substantial migration of nestin positive cells from the SVZ toward the tumor. Tumor growth resulted in decreased numbers of bromodeoxyuridine positive and Ki-67 positive proliferating cells and a concomitant increase in doublecortin and polysialylated neural cell adhesion molecule immunoreactivity within the SVZ. Neuroblasts were observed in high numbers in the area between the SVZ and the tumor, most likely pointing to the... (More)
The subventricular zone (SVZ) is one of the neurogenic regions of the adult brain. We characterized the neurogenic response of the SVZ to the growth of brain tumors in the rat striatum. Abundant nestin positive cells, most likely representing reactive astrocytes, were found surrounding the tumor. However, we observed no substantial migration of nestin positive cells from the SVZ toward the tumor. Tumor growth resulted in decreased numbers of bromodeoxyuridine positive and Ki-67 positive proliferating cells and a concomitant increase in doublecortin and polysialylated neural cell adhesion molecule immunoreactivity within the SVZ. Neuroblasts were observed in high numbers in the area between the SVZ and the tumor, most likely pointing to the SVZ as the principal source of these cells. Neuroblasts located between the SVZ and the tumor expressed the transcription factor Pbx, a marker for immature striatal neurons. However, no evidence of neuroblast differentiation into fully mature neurons was found. This study thus demonstrates increased neuroblast immunoreactivity within the SVZ ipsilateral to a brain tumor in the striatum. SVZ-derived neuroblasts attracted by the tumor adopt an immature striatal phenotype indicating a region specific reparative mechanism in response to a malignant tumor. (C) 2007 IBRO. Published by Elsevier Ltd. All rights reserved. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
neurogenesis, rat, glioma, doublecortin, brain tumor, neuroblast
in
Neuroscience
volume
147
issue
3
pages
824 - 832
publisher
Elsevier
external identifiers
  • wos:000248144900027
  • scopus:34347211047
ISSN
1873-7544
DOI
10.1016/j.neuroscience.2007.04.058
language
English
LU publication?
yes
id
4d84163b-8d4b-4ddc-9447-918ef0c0a0eb (old id 693151)
date added to LUP
2007-12-10 09:29:08
date last changed
2017-07-09 03:37:31
@article{4d84163b-8d4b-4ddc-9447-918ef0c0a0eb,
  abstract     = {The subventricular zone (SVZ) is one of the neurogenic regions of the adult brain. We characterized the neurogenic response of the SVZ to the growth of brain tumors in the rat striatum. Abundant nestin positive cells, most likely representing reactive astrocytes, were found surrounding the tumor. However, we observed no substantial migration of nestin positive cells from the SVZ toward the tumor. Tumor growth resulted in decreased numbers of bromodeoxyuridine positive and Ki-67 positive proliferating cells and a concomitant increase in doublecortin and polysialylated neural cell adhesion molecule immunoreactivity within the SVZ. Neuroblasts were observed in high numbers in the area between the SVZ and the tumor, most likely pointing to the SVZ as the principal source of these cells. Neuroblasts located between the SVZ and the tumor expressed the transcription factor Pbx, a marker for immature striatal neurons. However, no evidence of neuroblast differentiation into fully mature neurons was found. This study thus demonstrates increased neuroblast immunoreactivity within the SVZ ipsilateral to a brain tumor in the striatum. SVZ-derived neuroblasts attracted by the tumor adopt an immature striatal phenotype indicating a region specific reparative mechanism in response to a malignant tumor. (C) 2007 IBRO. Published by Elsevier Ltd. All rights reserved.},
  author       = {Bexell, Daniel and Gunnarsson, Salina and Nordquist, J. and Bengzon, Johan},
  issn         = {1873-7544},
  keyword      = {neurogenesis,rat,glioma,doublecortin,brain tumor,neuroblast},
  language     = {eng},
  number       = {3},
  pages        = {824--832},
  publisher    = {Elsevier},
  series       = {Neuroscience},
  title        = {Characterization of the subventricular zone neurogenic response to rat malignant brain tumors},
  url          = {http://dx.doi.org/10.1016/j.neuroscience.2007.04.058},
  volume       = {147},
  year         = {2007},
}