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Increased renal arterial resistance predicts the course of renal function in type 2 diabetes with microalbuminuria

Nosadini, R ; Velussi, M ; Brocco, E ; Abaterusso, C ; Carraro, A ; Piarulli, F ; Morgia, G ; Satta, A ; Faedda, R and Abhyankar, Avinash LU , et al. (2006) In Diabetes 55(1). p.234-239
Abstract
Type 2 diabetic patients often die because of end-stage renal failure, but no definitive reliable factor predicting long-term renal outcome has been identified. We tested whether a renal arterial resistance index (R/I) >= 80, using Doppler ultrasound technique, was predictive of worsening renal function. The primary end points of the study were 1) the course of glomerular filtration rate (GFR) and 2) the albumin excretion rate in 157 microalbuminuric, hypertensive, type 2 diabetic patients after a 7.8-year follow-up period (range 7.1-9.2). Kaplan-Meier curves for the primary end point (decrease of GFR 3.0 ml/min per 1.73 in per year) was two to three times more frequently observed in patients with R/I >= 80. Four- to fivefold fewer... (More)
Type 2 diabetic patients often die because of end-stage renal failure, but no definitive reliable factor predicting long-term renal outcome has been identified. We tested whether a renal arterial resistance index (R/I) >= 80, using Doppler ultrasound technique, was predictive of worsening renal function. The primary end points of the study were 1) the course of glomerular filtration rate (GFR) and 2) the albumin excretion rate in 157 microalbuminuric, hypertensive, type 2 diabetic patients after a 7.8-year follow-up period (range 7.1-9.2). Kaplan-Meier curves for the primary end point (decrease of GFR 3.0 ml/min per 1.73 in per year) was two to three times more frequently observed in patients with R/I >= 80. Four- to fivefold fewer patients showed a regression to normoalbuminuria during the follow-up period from baseline microalbuminuria in the cohort with R/I >= 80. Overt proteinuria did develop in 24% of patients with R/I >= 80 and in 5% of patients with R/I <80 (P < 0.01). In conclusion, intrarenal arterial resistance appears to play a nontrivial role in deteriorating renal function in type 2 diabetic patients. R/I is a noninvasive diagnostic procedure, which strongly predicts the outcome of renal function in type 2 diabetic patients, even when GFR patterns are still normal. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes
volume
55
issue
1
pages
234 - 239
publisher
American Diabetes Association Inc.
external identifiers
  • wos:000234349500029
  • pmid:16380498
  • scopus:33644764917
ISSN
1939-327X
DOI
10.2337/diabetes.55.01.06.db05-0881
language
English
LU publication?
yes
id
6f60ad27-59dc-47bb-9a42-790d89c6f559 (old id 693738)
date added to LUP
2016-04-01 17:14:31
date last changed
2021-03-24 04:39:34
@article{6f60ad27-59dc-47bb-9a42-790d89c6f559,
  abstract     = {Type 2 diabetic patients often die because of end-stage renal failure, but no definitive reliable factor predicting long-term renal outcome has been identified. We tested whether a renal arterial resistance index (R/I) &gt;= 80, using Doppler ultrasound technique, was predictive of worsening renal function. The primary end points of the study were 1) the course of glomerular filtration rate (GFR) and 2) the albumin excretion rate in 157 microalbuminuric, hypertensive, type 2 diabetic patients after a 7.8-year follow-up period (range 7.1-9.2). Kaplan-Meier curves for the primary end point (decrease of GFR 3.0 ml/min per 1.73 in per year) was two to three times more frequently observed in patients with R/I &gt;= 80. Four- to fivefold fewer patients showed a regression to normoalbuminuria during the follow-up period from baseline microalbuminuria in the cohort with R/I &gt;= 80. Overt proteinuria did develop in 24% of patients with R/I &gt;= 80 and in 5% of patients with R/I &lt;80 (P &lt; 0.01). In conclusion, intrarenal arterial resistance appears to play a nontrivial role in deteriorating renal function in type 2 diabetic patients. R/I is a noninvasive diagnostic procedure, which strongly predicts the outcome of renal function in type 2 diabetic patients, even when GFR patterns are still normal.},
  author       = {Nosadini, R and Velussi, M and Brocco, E and Abaterusso, C and Carraro, A and Piarulli, F and Morgia, G and Satta, A and Faedda, R and Abhyankar, Avinash and Luthman, Holger and Tonolo, G},
  issn         = {1939-327X},
  language     = {eng},
  number       = {1},
  pages        = {234--239},
  publisher    = {American Diabetes Association Inc.},
  series       = {Diabetes},
  title        = {Increased renal arterial resistance predicts the course of renal function in type 2 diabetes with microalbuminuria},
  url          = {http://dx.doi.org/10.2337/diabetes.55.01.06.db05-0881},
  doi          = {10.2337/diabetes.55.01.06.db05-0881},
  volume       = {55},
  year         = {2006},
}