Increased renal arterial resistance predicts the course of renal function in type 2 diabetes with microalbuminuria
(2006) In Diabetes 55(1). p.234-239- Abstract
- Type 2 diabetic patients often die because of end-stage renal failure, but no definitive reliable factor predicting long-term renal outcome has been identified. We tested whether a renal arterial resistance index (R/I) >= 80, using Doppler ultrasound technique, was predictive of worsening renal function. The primary end points of the study were 1) the course of glomerular filtration rate (GFR) and 2) the albumin excretion rate in 157 microalbuminuric, hypertensive, type 2 diabetic patients after a 7.8-year follow-up period (range 7.1-9.2). Kaplan-Meier curves for the primary end point (decrease of GFR 3.0 ml/min per 1.73 in per year) was two to three times more frequently observed in patients with R/I >= 80. Four- to fivefold fewer... (More)
- Type 2 diabetic patients often die because of end-stage renal failure, but no definitive reliable factor predicting long-term renal outcome has been identified. We tested whether a renal arterial resistance index (R/I) >= 80, using Doppler ultrasound technique, was predictive of worsening renal function. The primary end points of the study were 1) the course of glomerular filtration rate (GFR) and 2) the albumin excretion rate in 157 microalbuminuric, hypertensive, type 2 diabetic patients after a 7.8-year follow-up period (range 7.1-9.2). Kaplan-Meier curves for the primary end point (decrease of GFR 3.0 ml/min per 1.73 in per year) was two to three times more frequently observed in patients with R/I >= 80. Four- to fivefold fewer patients showed a regression to normoalbuminuria during the follow-up period from baseline microalbuminuria in the cohort with R/I >= 80. Overt proteinuria did develop in 24% of patients with R/I >= 80 and in 5% of patients with R/I <80 (P < 0.01). In conclusion, intrarenal arterial resistance appears to play a nontrivial role in deteriorating renal function in type 2 diabetic patients. R/I is a noninvasive diagnostic procedure, which strongly predicts the outcome of renal function in type 2 diabetic patients, even when GFR patterns are still normal. (Less)
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https://lup.lub.lu.se/record/693738
- author
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes
- volume
- 55
- issue
- 1
- pages
- 234 - 239
- publisher
- American Diabetes Association Inc.
- external identifiers
-
- wos:000234349500029
- pmid:16380498
- scopus:33644764917
- ISSN
- 1939-327X
- DOI
- 10.2337/diabetes.55.01.06.db05-0881
- language
- English
- LU publication?
- yes
- id
- 6f60ad27-59dc-47bb-9a42-790d89c6f559 (old id 693738)
- date added to LUP
- 2016-04-01 17:14:31
- date last changed
- 2022-03-30 21:30:14
@article{6f60ad27-59dc-47bb-9a42-790d89c6f559, abstract = {{Type 2 diabetic patients often die because of end-stage renal failure, but no definitive reliable factor predicting long-term renal outcome has been identified. We tested whether a renal arterial resistance index (R/I) >= 80, using Doppler ultrasound technique, was predictive of worsening renal function. The primary end points of the study were 1) the course of glomerular filtration rate (GFR) and 2) the albumin excretion rate in 157 microalbuminuric, hypertensive, type 2 diabetic patients after a 7.8-year follow-up period (range 7.1-9.2). Kaplan-Meier curves for the primary end point (decrease of GFR 3.0 ml/min per 1.73 in per year) was two to three times more frequently observed in patients with R/I >= 80. Four- to fivefold fewer patients showed a regression to normoalbuminuria during the follow-up period from baseline microalbuminuria in the cohort with R/I >= 80. Overt proteinuria did develop in 24% of patients with R/I >= 80 and in 5% of patients with R/I <80 (P < 0.01). In conclusion, intrarenal arterial resistance appears to play a nontrivial role in deteriorating renal function in type 2 diabetic patients. R/I is a noninvasive diagnostic procedure, which strongly predicts the outcome of renal function in type 2 diabetic patients, even when GFR patterns are still normal.}}, author = {{Nosadini, R and Velussi, M and Brocco, E and Abaterusso, C and Carraro, A and Piarulli, F and Morgia, G and Satta, A and Faedda, R and Abhyankar, Avinash and Luthman, Holger and Tonolo, G}}, issn = {{1939-327X}}, language = {{eng}}, number = {{1}}, pages = {{234--239}}, publisher = {{American Diabetes Association Inc.}}, series = {{Diabetes}}, title = {{Increased renal arterial resistance predicts the course of renal function in type 2 diabetes with microalbuminuria}}, url = {{http://dx.doi.org/10.2337/diabetes.55.01.06.db05-0881}}, doi = {{10.2337/diabetes.55.01.06.db05-0881}}, volume = {{55}}, year = {{2006}}, }