Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Differential expression of viral agents in lymphoma tissues of patients with ABC diffuse large B-cell lymphoma from high and low endemic infectious disease regions

Högfeldt, Therese ; Jaing, Crystal ; McLoughlin, Kevin ; Thissen, James ; Gardner, Shea ; Bahnassy, Abeer A. ; Gharizadeh, Baback ; Lundahl, Joachim ; Österborg, Anders and Porwit, Anna LU , et al. (2016) In Oncology Letters 12(4). p.2782-2788
Abstract

Diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin’s lymphoma (NHL) in adults, accounts for approximately 30-40% of newly diagnosed lymphomas worldwide. Environmental factors, such as viruses and bacteria, may contribute to cancer development through chronic inflammation and the integration of oncogenes, and have previously been indicated in cervical cancer, hepatocellular carcinoma, gastric cancer and lymphoproliferative disorders. In the present study, the presence of microbial agents was analyzed in the lymphoma tissue of patients with activated B-cell like (ABC) DLBCL. The present study compared two groups of patients from geographically varied regions that possess a difference in the prevalence of viral and... (More)

Diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin’s lymphoma (NHL) in adults, accounts for approximately 30-40% of newly diagnosed lymphomas worldwide. Environmental factors, such as viruses and bacteria, may contribute to cancer development through chronic inflammation and the integration of oncogenes, and have previously been indicated in cervical cancer, hepatocellular carcinoma, gastric cancer and lymphoproliferative disorders. In the present study, the presence of microbial agents was analyzed in the lymphoma tissue of patients with activated B-cell like (ABC) DLBCL. The present study compared two groups of patients from geographically varied regions that possess a difference in the prevalence of viral and other microbial agents. The patient populations were from Sweden (a low endemic infectious disease region) and Egypt (a high endemic infectious disease region). A differential expression of several viruses in lymphoma tissues was noted when comparing Swedish and Egyptian patients. JC polyomavirus (JCV) was detected in Swedish and Egyptian patients and, uniquely, the complete hepatitis B virus (HBV) genome was detected only in Egyptian lymphoma patients. None of these viruses were detected in control lymph tissues from Sweden or Egypt. In total, 38% of the Egyptian patients were found to have HBV surface antigens (HBsAgs) in their serum; however, HBsAgs were not found in any of the Swedish patients. The percentage of serum HBsAgs in Egyptian patients with ABC DLBCL was significantly increased compared with the general Egyptian population (P<0.05). The present study may support a notion that viral agents, including JCV and HBV, may be involved in the tumorigenesis of DLBCL in regions of high infectious disease.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; and (Less)
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Gene array, Hepatitis B virus, Lymphoma and Hodgkin disease, Molecular genetics, Virus
in
Oncology Letters
volume
12
issue
4
pages
7 pages
publisher
Spandidos Publications
external identifiers
  • scopus:84983388463
ISSN
1792-1074
DOI
10.3892/ol.2016.5012
language
English
LU publication?
no
id
69466f6d-ff15-4a16-94ff-3c022d0e2c9a
date added to LUP
2019-05-22 09:38:47
date last changed
2022-01-31 20:32:50
@article{69466f6d-ff15-4a16-94ff-3c022d0e2c9a,
  abstract     = {{<p>Diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin’s lymphoma (NHL) in adults, accounts for approximately 30-40% of newly diagnosed lymphomas worldwide. Environmental factors, such as viruses and bacteria, may contribute to cancer development through chronic inflammation and the integration of oncogenes, and have previously been indicated in cervical cancer, hepatocellular carcinoma, gastric cancer and lymphoproliferative disorders. In the present study, the presence of microbial agents was analyzed in the lymphoma tissue of patients with activated B-cell like (ABC) DLBCL. The present study compared two groups of patients from geographically varied regions that possess a difference in the prevalence of viral and other microbial agents. The patient populations were from Sweden (a low endemic infectious disease region) and Egypt (a high endemic infectious disease region). A differential expression of several viruses in lymphoma tissues was noted when comparing Swedish and Egyptian patients. JC polyomavirus (JCV) was detected in Swedish and Egyptian patients and, uniquely, the complete hepatitis B virus (HBV) genome was detected only in Egyptian lymphoma patients. None of these viruses were detected in control lymph tissues from Sweden or Egypt. In total, 38% of the Egyptian patients were found to have HBV surface antigens (HBsAgs) in their serum; however, HBsAgs were not found in any of the Swedish patients. The percentage of serum HBsAgs in Egyptian patients with ABC DLBCL was significantly increased compared with the general Egyptian population (P&lt;0.05). The present study may support a notion that viral agents, including JCV and HBV, may be involved in the tumorigenesis of DLBCL in regions of high infectious disease.</p>}},
  author       = {{Högfeldt, Therese and Jaing, Crystal and McLoughlin, Kevin and Thissen, James and Gardner, Shea and Bahnassy, Abeer A. and Gharizadeh, Baback and Lundahl, Joachim and Österborg, Anders and Porwit, Anna and Zekri, Abdel Rahman N. and Khaled, Hussein M. and Mellstedt, Håkan and Moshfegh, Ali}},
  issn         = {{1792-1074}},
  keywords     = {{Gene array; Hepatitis B virus; Lymphoma and Hodgkin disease; Molecular genetics; Virus}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{4}},
  pages        = {{2782--2788}},
  publisher    = {{Spandidos Publications}},
  series       = {{Oncology Letters}},
  title        = {{Differential expression of viral agents in lymphoma tissues of patients with ABC diffuse large B-cell lymphoma from high and low endemic infectious disease regions}},
  url          = {{http://dx.doi.org/10.3892/ol.2016.5012}},
  doi          = {{10.3892/ol.2016.5012}},
  volume       = {{12}},
  year         = {{2016}},
}