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Proopiomelanocortin and melanocortin receptors in the adult rat retino-tectal system and their regulation after optic nerve transection

Lindqvist, Niclas LU ; Näpänkangas, Ulla; Lindblom, Jonas and Hallböök, Finn (2003) In European Journal of Pharmacology 482(1-3). p.85-94
Abstract

The aim of this study was to characterise the expression of the melanocortin system in the normal and injured rat visual system. Using real-time polymerase chain reaction and immunohistochemistry, we detected melanocortin MC3, MC4 and MC5 receptors and proopiomelanocortin in adult retina and superior colliculus. Melanocortin MC4 receptor mRNA was the most abundant receptor. Melanocortin MC3, MC4 and MC5 receptors were localised to the ganglion cell and inner nuclear layers and the melanocortin MC3 and MC4 receptors were localised to retinal ganglion cells. Transection of the optic nerve leads to ganglion cell death and both melanocortin... (More)

The aim of this study was to characterise the expression of the melanocortin system in the normal and injured rat visual system. Using real-time polymerase chain reaction and immunohistochemistry, we detected melanocortin MC3, MC4 and MC5 receptors and proopiomelanocortin in adult retina and superior colliculus. Melanocortin MC4 receptor mRNA was the most abundant receptor. Melanocortin MC3, MC4 and MC5 receptors were localised to the ganglion cell and inner nuclear layers and the melanocortin MC3 and MC4 receptors were localised to retinal ganglion cells. Transection of the optic nerve leads to ganglion cell death and both melanocortin receptor and proopiomelanocortin expression decreased in superior colliculus after transection whereas the expression was unchanged or even increased in the retina. α-Melanocyte-stimulating hormone elicited neurite outgrowth from embryonic retinal explants. Together, these data implicate a role for the melanocortin system in the adult rat retina and that melanocortins can stimulate neurite growth from retinal neurons.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Axotomy, Injury, Melanocortin receptor, mRNA expression, POMC (proopiomelanocortin), Retina
in
European Journal of Pharmacology
volume
482
issue
1-3
pages
10 pages
publisher
Elsevier
external identifiers
  • scopus:0345167916
ISSN
0014-2999
DOI
10.1016/j.ejphar.2003.10.011
language
English
LU publication?
no
id
6957783c-8412-498a-a36d-666bf334db20
date added to LUP
2017-06-02 15:18:12
date last changed
2017-06-26 09:18:21
@article{6957783c-8412-498a-a36d-666bf334db20,
  abstract     = {<p>The aim of this study was to characterise the expression of the melanocortin system in the normal and injured rat visual system. Using real-time polymerase chain reaction and immunohistochemistry, we detected melanocortin MC<sub>3</sub>, MC<sub>4</sub> and MC<sub>5</sub> receptors and proopiomelanocortin in adult retina and superior colliculus. Melanocortin MC<sub>4</sub> receptor mRNA was the most abundant receptor. Melanocortin MC<sub>3</sub>, MC<sub>4</sub> and MC<sub>5</sub> receptors were localised to the ganglion cell and inner nuclear layers and the melanocortin MC<sub>3</sub> and MC<sub>4</sub> receptors were localised to retinal ganglion cells. Transection of the optic nerve leads to ganglion cell death and both melanocortin receptor and proopiomelanocortin expression decreased in superior colliculus after transection whereas the expression was unchanged or even increased in the retina. α-Melanocyte-stimulating hormone elicited neurite outgrowth from embryonic retinal explants. Together, these data implicate a role for the melanocortin system in the adult rat retina and that melanocortins can stimulate neurite growth from retinal neurons.</p>},
  author       = {Lindqvist, Niclas and Näpänkangas, Ulla and Lindblom, Jonas and Hallböök, Finn},
  issn         = {0014-2999},
  keyword      = {Axotomy,Injury,Melanocortin receptor,mRNA expression,POMC (proopiomelanocortin),Retina},
  language     = {eng},
  month        = {12},
  number       = {1-3},
  pages        = {85--94},
  publisher    = {Elsevier},
  series       = {European Journal of Pharmacology},
  title        = {Proopiomelanocortin and melanocortin receptors in the adult rat retino-tectal system and their regulation after optic nerve transection},
  url          = {http://dx.doi.org/10.1016/j.ejphar.2003.10.011},
  volume       = {482},
  year         = {2003},
}