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Asymmetric ring-opening of epoxides catalyzed by metal–salen complexes

Lidskog, Anna LU ; Li, Yutang LU and Wärnmark, Kenneth LU (2020) In Catalysts 10(6).
Abstract

The asymmetric ring-opening of epoxides is an important reaction in organic synthesis, since it allows for the enantioselective installation of two vicinal functional groups with specific stereochemistry within one step from a highly available starting material. An effective class of catalysts for the asymmetric ring-opening of epoxides is metal–salen complexes. This review summarizes the development of metal–salen catalyzed enantioselective desymmetrization of meso-epoxides and kinetic resolution of epoxides with various nucleophiles, including the design and application of both homogeneous- and heterogeneous epoxide-opening catalysts as well as multi-metallic covalent and supramolecular catalytic systems.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Asymmetric catalysis, Epoxide, Kinetic resolution, Ring-opening, Salen complexes
in
Catalysts
volume
10
issue
6
article number
705
publisher
MDPI AG
external identifiers
  • scopus:85089116461
ISSN
2073-4344
DOI
10.3390/catal10060705
language
English
LU publication?
yes
id
695ae940-ef35-496e-ba5a-111be2f2dfd1
date added to LUP
2020-08-18 13:16:48
date last changed
2025-10-14 10:43:50
@article{695ae940-ef35-496e-ba5a-111be2f2dfd1,
  abstract     = {{<p>The asymmetric ring-opening of epoxides is an important reaction in organic synthesis, since it allows for the enantioselective installation of two vicinal functional groups with specific stereochemistry within one step from a highly available starting material. An effective class of catalysts for the asymmetric ring-opening of epoxides is metal–salen complexes. This review summarizes the development of metal–salen catalyzed enantioselective desymmetrization of meso-epoxides and kinetic resolution of epoxides with various nucleophiles, including the design and application of both homogeneous- and heterogeneous epoxide-opening catalysts as well as multi-metallic covalent and supramolecular catalytic systems.</p>}},
  author       = {{Lidskog, Anna and Li, Yutang and Wärnmark, Kenneth}},
  issn         = {{2073-4344}},
  keywords     = {{Asymmetric catalysis; Epoxide; Kinetic resolution; Ring-opening; Salen complexes}},
  language     = {{eng}},
  number       = {{6}},
  publisher    = {{MDPI AG}},
  series       = {{Catalysts}},
  title        = {{Asymmetric ring-opening of epoxides catalyzed by metal–salen complexes}},
  url          = {{http://dx.doi.org/10.3390/catal10060705}},
  doi          = {{10.3390/catal10060705}},
  volume       = {{10}},
  year         = {{2020}},
}