Cystatin C-based equations for estimating glomerular filtration rate do not require race or sex coefficients.
Ottosson Frost, Carl ; Gille-Johnson, Per ; Blomstrand, Emanuel ; St-Aubin, Viggo ; Leion, Felicia and Grubb, Anders LU
(2022)
In Scandinavian Journal of Clinical & Laboratory Investigation
82(2).
p.162-166
- Abstract
- Estimation or measurement of glomerular filtration rate (GFR) is generally required for optimal treatment of patients. Plasma creatinine has been used for estimation of GFR since 1926 and plasma cystatin C since 1979. The creatinine level is strongly dependent upon muscle mass and as the average muscle mass of dif- ferent populations may vary, creatinine-based GFR-estimating equations have since 1999 used more than 10 different race coefficients to improve the diagnostic performance of such equations. But ‘race’ cannot be determined by biological measurements and is thus an ill-defined biological entity and controversial as it involves self-reporting and social considerations. In contrast, cystatin C-levels are virtually independent of... (More)
- Estimation or measurement of glomerular filtration rate (GFR) is generally required for optimal treatment of patients. Plasma creatinine has been used for estimation of GFR since 1926 and plasma cystatin C since 1979. The creatinine level is strongly dependent upon muscle mass and as the average muscle mass of dif- ferent populations may vary, creatinine-based GFR-estimating equations have since 1999 used more than 10 different race coefficients to improve the diagnostic performance of such equations. But ‘race’ cannot be determined by biological measurements and is thus an ill-defined biological entity and controversial as it involves self-reporting and social considerations. In contrast, cystatin C-levels are virtually independent of muscular mass and cystatin C-based GFR-estimating equations do not require race coefficients for reliable estimation of GFR. The use of cystatin C-based GFR-estimating equations, alone or in conjunction with creatinine-based GFR-estimating equations, is therefore highly recommended to eliminate the use of race coefficients in estimating GFR. Although sex is a more biology-oriented parameter than race, sex terms may in some cases be controversial, involving self-reporting and social considerations. However, sex terms are not required for adequate estimation of GFR using cystatin C-based equations. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/6969c4be-618f-47c3-96e4-7d2c936d43ed
- author
- Ottosson Frost, Carl
; Gille-Johnson, Per
; Blomstrand, Emanuel
; St-Aubin, Viggo
; Leion, Felicia
and Grubb, Anders
LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Creatinine, cystatin C, glomerular filtration rate, race, sex
- in
- Scandinavian Journal of Clinical & Laboratory Investigation
- volume
- 82
- issue
- 2
- pages
- 162 - 166
- publisher
- Informa Healthcare
- external identifiers
-
- pmid:35107398
- scopus:85124316093
- ISSN
- 1502-7686
- DOI
- 10.1080/00365513.2022.2031279
- language
- English
- LU publication?
- yes
- id
- 6969c4be-618f-47c3-96e4-7d2c936d43ed
- date added to LUP
- 2022-02-18 18:31:18
- date last changed
- 2023-03-25 02:08:43
@article{6969c4be-618f-47c3-96e4-7d2c936d43ed,
abstract = {{Estimation or measurement of glomerular filtration rate (GFR) is generally required for optimal treatment of patients. Plasma creatinine has been used for estimation of GFR since 1926 and plasma cystatin C since 1979. The creatinine level is strongly dependent upon muscle mass and as the average muscle mass of dif- ferent populations may vary, creatinine-based GFR-estimating equations have since 1999 used more than 10 different race coefficients to improve the diagnostic performance of such equations. But ‘race’ cannot be determined by biological measurements and is thus an ill-defined biological entity and controversial as it involves self-reporting and social considerations. In contrast, cystatin C-levels are virtually independent of muscular mass and cystatin C-based GFR-estimating equations do not require race coefficients for reliable estimation of GFR. The use of cystatin C-based GFR-estimating equations, alone or in conjunction with creatinine-based GFR-estimating equations, is therefore highly recommended to eliminate the use of race coefficients in estimating GFR. Although sex is a more biology-oriented parameter than race, sex terms may in some cases be controversial, involving self-reporting and social considerations. However, sex terms are not required for adequate estimation of GFR using cystatin C-based equations.}},
author = {{Ottosson Frost, Carl and Gille-Johnson, Per and Blomstrand, Emanuel and St-Aubin, Viggo and Leion, Felicia and Grubb, Anders}},
issn = {{1502-7686}},
keywords = {{Creatinine, cystatin C, glomerular filtration rate, race, sex}},
language = {{eng}},
number = {{2}},
pages = {{162--166}},
publisher = {{Informa Healthcare}},
series = {{Scandinavian Journal of Clinical & Laboratory Investigation}},
title = {{Cystatin C-based equations for estimating glomerular filtration rate do not require race or sex coefficients.}},
url = {{http://dx.doi.org/10.1080/00365513.2022.2031279}},
doi = {{10.1080/00365513.2022.2031279}},
volume = {{82}},
year = {{2022}},
}