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Mechanism of enterovirus involvement in epidemic neuropathy : hypothesis regarding pathophysiology

Lago, P M ; Guzmán, M G ; Sarmiento, L LU ; Pérez, A B ; Alvarez, M ; Capó, V ; Avalos, I and Flores, G K (2001) In Medical Hypotheses 56(3). p.47-339
Abstract

During the epidemic of optic and peripheral neuropathy which occurred in Cuba in 1992-1993, viruses antigenically related to the Coxsackie viruses were isolated from cerebrospinal fluid of patients. Concurrently with the virologic studies, epidemiologic, toxicologic, nutritional, immunologic, and histopathologic investigations were also carried out. Although it was demonstrated that the illness was associated with toxic and nutritional risk factors, it has not been possible to identify a specific etiology for the symptoms observed. Taking into consideration the results obtained in all of the various investigations, we have formulated an integral, multifactorial hypothesis which attempts to explain a pathophysiologic mechanism by which... (More)

During the epidemic of optic and peripheral neuropathy which occurred in Cuba in 1992-1993, viruses antigenically related to the Coxsackie viruses were isolated from cerebrospinal fluid of patients. Concurrently with the virologic studies, epidemiologic, toxicologic, nutritional, immunologic, and histopathologic investigations were also carried out. Although it was demonstrated that the illness was associated with toxic and nutritional risk factors, it has not been possible to identify a specific etiology for the symptoms observed. Taking into consideration the results obtained in all of the various investigations, we have formulated an integral, multifactorial hypothesis which attempts to explain a pathophysiologic mechanism by which the viruses isolated could participate in the pathogenesis of the illness. We propose that the viral agents produce a persistent infection, and the possibility that they may act as mediator of an autoimmune pathogenic process.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Coxsackievirus Infections/epidemiology, Cuba/epidemiology, Enterovirus/isolation & purification, Humans, Models, Biological, Models, Neurological, Optic Nerve Diseases/epidemiology, Peripheral Nervous System Diseases/epidemiology
in
Medical Hypotheses
volume
56
issue
3
pages
9 pages
publisher
Churchill Livingstone
external identifiers
  • scopus:0035040877
  • pmid:11359357
ISSN
0306-9877
DOI
10.1054/mehy.2000.1222
language
English
LU publication?
no
additional info
Copyright 2001 Harcourt Publishers Ltd.
id
6977475f-11cd-4a0f-86f1-8689de2f3a80
date added to LUP
2019-07-08 15:13:38
date last changed
2019-12-10 08:12:05
@article{6977475f-11cd-4a0f-86f1-8689de2f3a80,
  abstract     = {<p>During the epidemic of optic and peripheral neuropathy which occurred in Cuba in 1992-1993, viruses antigenically related to the Coxsackie viruses were isolated from cerebrospinal fluid of patients. Concurrently with the virologic studies, epidemiologic, toxicologic, nutritional, immunologic, and histopathologic investigations were also carried out. Although it was demonstrated that the illness was associated with toxic and nutritional risk factors, it has not been possible to identify a specific etiology for the symptoms observed. Taking into consideration the results obtained in all of the various investigations, we have formulated an integral, multifactorial hypothesis which attempts to explain a pathophysiologic mechanism by which the viruses isolated could participate in the pathogenesis of the illness. We propose that the viral agents produce a persistent infection, and the possibility that they may act as mediator of an autoimmune pathogenic process.</p>},
  author       = {Lago, P M and Guzmán, M G and Sarmiento, L and Pérez, A B and Alvarez, M and Capó, V and Avalos, I and Flores, G K},
  issn         = {0306-9877},
  language     = {eng},
  number       = {3},
  pages        = {47--339},
  publisher    = {Churchill Livingstone},
  series       = {Medical Hypotheses},
  title        = {Mechanism of enterovirus involvement in epidemic neuropathy : hypothesis regarding pathophysiology},
  url          = {http://dx.doi.org/10.1054/mehy.2000.1222},
  doi          = {10.1054/mehy.2000.1222},
  volume       = {56},
  year         = {2001},
}