Advanced

Influence of vasoactive drugs on blood flow in subcutaneous tumors – an experimental study in rats

Hafström, Larsolof ; Persson, Bertil LU and Sundqvist, Kaj (1980) In Journal of Surgical Oncology 14(4). p.359-366
Abstract

Subcutaneously implanted tumors in Wistar and Lister rats were used as a model for the study of metastatic tumor blood flow and how it is affected by vasoactive drugs. Blood flow measurements were obtained using the labelled microsphere method and the reference organ technique. Microspheres (15‐μm) labelled with either 99Tcm or 51 Cr isotopes were injected intracardially and a reference sample was drawn simultaneously at constant speed. This was performed before and after the infusion of vasoactive drugs, and (as control), saline infusion. The drugs tested (adrenaline, noradrenaline, glucagon, histamine, and vasopressin) showed profound effects on central hemodynamic parameters and on muscle and skin... (More)

Subcutaneously implanted tumors in Wistar and Lister rats were used as a model for the study of metastatic tumor blood flow and how it is affected by vasoactive drugs. Blood flow measurements were obtained using the labelled microsphere method and the reference organ technique. Microspheres (15‐μm) labelled with either 99Tcm or 51 Cr isotopes were injected intracardially and a reference sample was drawn simultaneously at constant speed. This was performed before and after the infusion of vasoactive drugs, and (as control), saline infusion. The drugs tested (adrenaline, noradrenaline, glucagon, histamine, and vasopressin) showed profound effects on central hemodynamic parameters and on muscle and skin blood flow. The relative tumor blood flow, measured as the ratio between tumor and skin or tumor and muscle blood flow, was calculated. The results show that no enhancement of the relative tumor blood flow could be registered. In fact, a decrease in the tumor‐to‐muscle‐blood‐flow ratio was noted when noradrenaline was infused, and in the tumor‐to‐skin ratio when adrenaline was infused. Blood flow in subcutaneous tumors was four to five times that in muscle or skin. Tumor blood flow was also inversely related to the size of the tumor.

(Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
microspheres, tumor blood flow, vasoactive drugs
in
Journal of Surgical Oncology
volume
14
issue
4
pages
8 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:7442262
  • scopus:0018962597
ISSN
0022-4790
DOI
10.1002/jso.2930140410
language
English
LU publication?
yes
id
699dcbda-05c5-4451-ba15-be945af22871
date added to LUP
2020-08-15 17:28:25
date last changed
2021-01-03 03:13:56
@article{699dcbda-05c5-4451-ba15-be945af22871,
  abstract     = {<p>Subcutaneously implanted tumors in Wistar and Lister rats were used as a model for the study of metastatic tumor blood flow and how it is affected by vasoactive drugs. Blood flow measurements were obtained using the labelled microsphere method and the reference organ technique. Microspheres (15‐μm) labelled with either <sup>99</sup>Tc<sup>m</sup> or <sup>51</sup> Cr isotopes were injected intracardially and a reference sample was drawn simultaneously at constant speed. This was performed before and after the infusion of vasoactive drugs, and (as control), saline infusion. The drugs tested (adrenaline, noradrenaline, glucagon, histamine, and vasopressin) showed profound effects on central hemodynamic parameters and on muscle and skin blood flow. The relative tumor blood flow, measured as the ratio between tumor and skin or tumor and muscle blood flow, was calculated. The results show that no enhancement of the relative tumor blood flow could be registered. In fact, a decrease in the tumor‐to‐muscle‐blood‐flow ratio was noted when noradrenaline was infused, and in the tumor‐to‐skin ratio when adrenaline was infused. Blood flow in subcutaneous tumors was four to five times that in muscle or skin. Tumor blood flow was also inversely related to the size of the tumor.</p>},
  author       = {Hafström, Larsolof and Persson, Bertil and Sundqvist, Kaj},
  issn         = {0022-4790},
  language     = {eng},
  month        = {01},
  number       = {4},
  pages        = {359--366},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Surgical Oncology},
  title        = {Influence of vasoactive drugs on blood flow in subcutaneous tumors – an experimental study in rats},
  url          = {http://dx.doi.org/10.1002/jso.2930140410},
  doi          = {10.1002/jso.2930140410},
  volume       = {14},
  year         = {1980},
}