Diversified physiological sensory input connectivity questions the existence of distinct classes of spinal interneurons
(2022) In iScience 25(4).- Abstract
The spinal cord is engaged in all forms of motor performance but its functions are far from understood. Because network connectivity defines function, we explored the connectivity of muscular, tendon, and tactile sensory inputs among a wide population of spinal interneurons in the lower cervical segments. Using low noise intracellular whole cell recordings in the decerebrated, non-anesthetized cat in vivo, we could define mono-, di-, and trisynaptic inputs as well as the weights of each input. Whereas each neuron had a highly specific input, and each indirect input could moreover be explained by inputs in other recorded neurons, we unexpectedly also found the input connectivity of the spinal interneuron population to form a continuum.... (More)
The spinal cord is engaged in all forms of motor performance but its functions are far from understood. Because network connectivity defines function, we explored the connectivity of muscular, tendon, and tactile sensory inputs among a wide population of spinal interneurons in the lower cervical segments. Using low noise intracellular whole cell recordings in the decerebrated, non-anesthetized cat in vivo, we could define mono-, di-, and trisynaptic inputs as well as the weights of each input. Whereas each neuron had a highly specific input, and each indirect input could moreover be explained by inputs in other recorded neurons, we unexpectedly also found the input connectivity of the spinal interneuron population to form a continuum. Our data hence contrasts with the currently widespread notion of distinct classes of interneurons. We argue that this suggested diversified physiological connectivity, which likely requires a major component of circuitry learning, implies a more flexible functionality.
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- author
- Kohler, Matthias ; Bengtsson, Fredrik ; Stratmann, Philipp ; Röhrbein, Florian ; Knoll, Alois ; Albu-Schäffer, Alin and Jörntell, Henrik LU
- organization
- publishing date
- 2022-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Behavioral neuroscience, Biological sciences, Cellular neuroscience
- in
- iScience
- volume
- 25
- issue
- 4
- article number
- 104083
- publisher
- Elsevier
- external identifiers
-
- pmid:35372805
- scopus:85127128629
- ISSN
- 2589-0042
- DOI
- 10.1016/j.isci.2022.104083
- language
- English
- LU publication?
- yes
- id
- 699e390b-4aac-4751-b735-4977c9f092ad
- date added to LUP
- 2022-05-20 14:07:50
- date last changed
- 2024-06-27 13:40:01
@article{699e390b-4aac-4751-b735-4977c9f092ad,
abstract = {{<p>The spinal cord is engaged in all forms of motor performance but its functions are far from understood. Because network connectivity defines function, we explored the connectivity of muscular, tendon, and tactile sensory inputs among a wide population of spinal interneurons in the lower cervical segments. Using low noise intracellular whole cell recordings in the decerebrated, non-anesthetized cat in vivo, we could define mono-, di-, and trisynaptic inputs as well as the weights of each input. Whereas each neuron had a highly specific input, and each indirect input could moreover be explained by inputs in other recorded neurons, we unexpectedly also found the input connectivity of the spinal interneuron population to form a continuum. Our data hence contrasts with the currently widespread notion of distinct classes of interneurons. We argue that this suggested diversified physiological connectivity, which likely requires a major component of circuitry learning, implies a more flexible functionality.</p>}},
author = {{Kohler, Matthias and Bengtsson, Fredrik and Stratmann, Philipp and Röhrbein, Florian and Knoll, Alois and Albu-Schäffer, Alin and Jörntell, Henrik}},
issn = {{2589-0042}},
keywords = {{Behavioral neuroscience; Biological sciences; Cellular neuroscience}},
language = {{eng}},
number = {{4}},
publisher = {{Elsevier}},
series = {{iScience}},
title = {{Diversified physiological sensory input connectivity questions the existence of distinct classes of spinal interneurons}},
url = {{http://dx.doi.org/10.1016/j.isci.2022.104083}},
doi = {{10.1016/j.isci.2022.104083}},
volume = {{25}},
year = {{2022}},
}