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Low sex hormone-binding globulin is associated with hypertension: a cross-sectional study in a Swedish population

Daka, Bledar; Rosen, Thord; Jansson, Per Anders; Larsson, Charlotte A LU ; Råstam, Lennart LU and Lindblad, Ulf (2013) In BMC Cardiovascular Disorders 13.
Abstract
Background: The aim of this study was to investigate the association of sex hormone-binding globulin (SHBG) and hypertension in a Swedish population. Methods: The study is based on a random sample of a Swedish population of men and women aged 30-74 years (n=2,816). Total testosterone, oestradiol and SHBG were measured in 2,782 participants. Free androgen index was then calculated according to the formula FAI=100 x (Total testosterone)/SHBG. Hypertension was diagnosed according to JNC7. Results: In men, but not in women, significant association between SHBG and both diastolic (diastolic blood pressure: beta=-0.143 p<0.001) and systolic blood pressure (systolic blood pressure beta=-0.114 p<0.001) was found. The association was still... (More)
Background: The aim of this study was to investigate the association of sex hormone-binding globulin (SHBG) and hypertension in a Swedish population. Methods: The study is based on a random sample of a Swedish population of men and women aged 30-74 years (n=2,816). Total testosterone, oestradiol and SHBG were measured in 2,782 participants. Free androgen index was then calculated according to the formula FAI=100 x (Total testosterone)/SHBG. Hypertension was diagnosed according to JNC7. Results: In men, but not in women, significant association between SHBG and both diastolic (diastolic blood pressure: beta=-0.143 p<0.001) and systolic blood pressure (systolic blood pressure beta=-0.114 p<0.001) was found. The association was still significant after adjusting for age, body mass index (BMI), homeostatic model assessment insulin resistance (HOMA-IR), triglycerides, high density lipoproteins (HDL) and C-reactive protein (CRP) (diastolic blood pressure: beta=-0.113 p<0.001; systolic blood pressure beta=-0.093 p=0.001). An inverse association was observed between SHBG and hypertension in both men (B=-0.024 p<0.001) and women (B=-0.022 p<0.001). The association was still significant in women older than 50 years after adjustments for age, BMI, physical activity, CRP and alcohol consumption (B=-0.014, p=0.008). Conclusion: In conclusion, these results show a strong association between SHBG and blood pressure independent of major determinants of high blood pressure. This association might be addressed to direct effects of SHBG in endothelial cells through the receptor for SHBG. If this is confirmed by other observational and experimental studies, it might become a new field for the development of therapies for lowering blood pressure. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Sex hormone binding globulin (SHBG), Testosterone, Gender, Hypertension, BMI
in
BMC Cardiovascular Disorders
volume
13
publisher
BioMed Central
external identifiers
  • wos:000319509100001
  • scopus:84876160807
ISSN
1471-2261
DOI
10.1186/1471-2261-13-30
language
English
LU publication?
yes
id
69a98ebc-e85d-41ef-8a9e-73ca3242938b (old id 3932277)
date added to LUP
2013-08-01 07:40:15
date last changed
2019-07-07 03:49:08
@article{69a98ebc-e85d-41ef-8a9e-73ca3242938b,
  abstract     = {Background: The aim of this study was to investigate the association of sex hormone-binding globulin (SHBG) and hypertension in a Swedish population. Methods: The study is based on a random sample of a Swedish population of men and women aged 30-74 years (n=2,816). Total testosterone, oestradiol and SHBG were measured in 2,782 participants. Free androgen index was then calculated according to the formula FAI=100 x (Total testosterone)/SHBG. Hypertension was diagnosed according to JNC7. Results: In men, but not in women, significant association between SHBG and both diastolic (diastolic blood pressure: beta=-0.143 p&lt;0.001) and systolic blood pressure (systolic blood pressure beta=-0.114 p&lt;0.001) was found. The association was still significant after adjusting for age, body mass index (BMI), homeostatic model assessment insulin resistance (HOMA-IR), triglycerides, high density lipoproteins (HDL) and C-reactive protein (CRP) (diastolic blood pressure: beta=-0.113 p&lt;0.001; systolic blood pressure beta=-0.093 p=0.001). An inverse association was observed between SHBG and hypertension in both men (B=-0.024 p&lt;0.001) and women (B=-0.022 p&lt;0.001). The association was still significant in women older than 50 years after adjustments for age, BMI, physical activity, CRP and alcohol consumption (B=-0.014, p=0.008). Conclusion: In conclusion, these results show a strong association between SHBG and blood pressure independent of major determinants of high blood pressure. This association might be addressed to direct effects of SHBG in endothelial cells through the receptor for SHBG. If this is confirmed by other observational and experimental studies, it might become a new field for the development of therapies for lowering blood pressure.},
  articleno    = {30},
  author       = {Daka, Bledar and Rosen, Thord and Jansson, Per Anders and Larsson, Charlotte A and Råstam, Lennart and Lindblad, Ulf},
  issn         = {1471-2261},
  keyword      = {Sex hormone binding globulin (SHBG),Testosterone,Gender,Hypertension,BMI},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {BMC Cardiovascular Disorders},
  title        = {Low sex hormone-binding globulin is associated with hypertension: a cross-sectional study in a Swedish population},
  url          = {http://dx.doi.org/10.1186/1471-2261-13-30},
  volume       = {13},
  year         = {2013},
}