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Tumor-tracking radiotherapy of moving targets; verification using 3D polymer gel, 2D ion-chamber array and biplanar diode array

Ceberg, Sofie LU ; Af Rosenschöld, Per Munck LU orcid ; Cattell, Herbert ; Gustafsson, Helen LU ; Keall, Paul ; Korreman, Stine S. ; Medin, Joakim LU ; Nordström, Fredrik LU ; Persson, Gitte and Sawant, Amit , et al. (2010) In Journal of Physics: Conference Series 250(1). p.235-239
Abstract

The aim of this study was to carry out a dosimetric verification of a dynamic multileaf collimator (DMLC)-based tumor-tracking delivery during respiratory-like motion. The advantage of tumor-tracking radiation delivery is the ability to allow a tighter margin around the target by continuously following and adapting the dose delivery to its motion. However, there are geometric and dosimetric uncertainties associated with beam delivery system constraints and output variations, and several investigations have to be accomplished before a clinical integration of this tracking technique. Two types of delivery were investigated in this study I) a single beam perpendicular to a target with a one dimensional motion parallel to the MLC moving... (More)

The aim of this study was to carry out a dosimetric verification of a dynamic multileaf collimator (DMLC)-based tumor-tracking delivery during respiratory-like motion. The advantage of tumor-tracking radiation delivery is the ability to allow a tighter margin around the target by continuously following and adapting the dose delivery to its motion. However, there are geometric and dosimetric uncertainties associated with beam delivery system constraints and output variations, and several investigations have to be accomplished before a clinical integration of this tracking technique. Two types of delivery were investigated in this study I) a single beam perpendicular to a target with a one dimensional motion parallel to the MLC moving direction, and II) an intensity modulated arc delivery (RapidArc®) with a target motion diagonal to the MLC moving direction. The feasibility study (I) was made using an 2D ionisation chamber array and a true 3D polymer gel. The arc delivery (II) was verified using polymer gel and a biplanar diode array. Good agreement in absorbed dose was found between delivery to a static target and to a moving target with DMLC tracking using all three detector systems. However, due to the limited spatial resolution of the 2D array a detailed comparison was not possible. The RapidArc® plan delivery was successfully verified using the biplanar diode array and true 3D polymer gel, and both detector systems could verify that the DMLC-based tumor-tracking delivery system has a very good ability to account for respiratory target motion.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Physics: Conference Series
volume
250
issue
1
article number
012051
pages
5 pages
publisher
IOP Publishing
external identifiers
  • scopus:78650584020
ISSN
1742-6588
DOI
10.1088/1742-6596/250/1/012051
language
English
LU publication?
yes
id
69b639f2-a9fa-4004-acdb-a446b51409f9
date added to LUP
2019-06-20 11:12:01
date last changed
2025-04-04 15:27:07
@article{69b639f2-a9fa-4004-acdb-a446b51409f9,
  abstract     = {{<p>The aim of this study was to carry out a dosimetric verification of a dynamic multileaf collimator (DMLC)-based tumor-tracking delivery during respiratory-like motion. The advantage of tumor-tracking radiation delivery is the ability to allow a tighter margin around the target by continuously following and adapting the dose delivery to its motion. However, there are geometric and dosimetric uncertainties associated with beam delivery system constraints and output variations, and several investigations have to be accomplished before a clinical integration of this tracking technique. Two types of delivery were investigated in this study I) a single beam perpendicular to a target with a one dimensional motion parallel to the MLC moving direction, and II) an intensity modulated arc delivery (RapidArc®) with a target motion diagonal to the MLC moving direction. The feasibility study (I) was made using an 2D ionisation chamber array and a true 3D polymer gel. The arc delivery (II) was verified using polymer gel and a biplanar diode array. Good agreement in absorbed dose was found between delivery to a static target and to a moving target with DMLC tracking using all three detector systems. However, due to the limited spatial resolution of the 2D array a detailed comparison was not possible. The RapidArc® plan delivery was successfully verified using the biplanar diode array and true 3D polymer gel, and both detector systems could verify that the DMLC-based tumor-tracking delivery system has a very good ability to account for respiratory target motion.</p>}},
  author       = {{Ceberg, Sofie and Af Rosenschöld, Per Munck and Cattell, Herbert and Gustafsson, Helen and Keall, Paul and Korreman, Stine S. and Medin, Joakim and Nordström, Fredrik and Persson, Gitte and Sawant, Amit and Svatos, Michelle and Zimmerman, Jens and Bäck, Sven Å J. and Falk, Marianne}},
  issn         = {{1742-6588}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{235--239}},
  publisher    = {{IOP Publishing}},
  series       = {{Journal of Physics: Conference Series}},
  title        = {{Tumor-tracking radiotherapy of moving targets; verification using 3D polymer gel, 2D ion-chamber array and biplanar diode array}},
  url          = {{http://dx.doi.org/10.1088/1742-6596/250/1/012051}},
  doi          = {{10.1088/1742-6596/250/1/012051}},
  volume       = {{250}},
  year         = {{2010}},
}