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The effect of head rotation on the geometry and hemodynamics of healthy vertebral arteries

Aristokleous, Nicolas LU ; Seimenis, Ioannis ; Georgiou, Georgios C ; Nicolaides, Andrew and Anayiotos, Andreas S (2015) In Annals of Biomedical Engineering 43(6). p.97-1287
Abstract

The geometric and hemodynamic characteristics of the left and right vertebral arteries (LVA, RVA) of six healthy volunteers were investigated for the supine (S) and the prone position (P) a common sleeping posture with head rotation. MRI images were used to reconstruct the subject specific three-dimensional solid models of the LVA and RVA from the level of the carotid bifurcation to the vertebrobasilar junction (VJ). Geometric parameters such as cross sectional area ratio, curvature, tortuosity and branch angle were estimated. MR-PCA was used to obtain the blood flow waveforms for the two positions and computational fluid dynamics (CFD) were used to assess the flow field in terms of wall shear stress (WSS) relative residence times (RRT)... (More)

The geometric and hemodynamic characteristics of the left and right vertebral arteries (LVA, RVA) of six healthy volunteers were investigated for the supine (S) and the prone position (P) a common sleeping posture with head rotation. MRI images were used to reconstruct the subject specific three-dimensional solid models of the LVA and RVA from the level of the carotid bifurcation to the vertebrobasilar junction (VJ). Geometric parameters such as cross sectional area ratio, curvature, tortuosity and branch angle were estimated. MR-PCA was used to obtain the blood flow waveforms for the two positions and computational fluid dynamics (CFD) were used to assess the flow field in terms of wall shear stress (WSS) relative residence times (RRT) and localized normalized helicity (LNH). Significant geometric changes but moderate flow changes were observed for both vertebral arteries with head rotation. The CFD results at the VJ show that head rotation causes changes in the WSS distribution, RRT and LNH. Further studies are warranted to assess the clinical significance of the results in terms of atherosclerosis development at the VJ and how the observed geometric changes may affect blood flow to the brain in healthy subjects and vertebral artery stenosis patients, and in terms of increased rapture susceptibility in vertebrobasilar aneurysm patients.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Blood Flow Velocity/physiology, Computer Simulation, Head, Humans, Magnetic Resonance Angiography, Male, Models, Cardiovascular, Movement/physiology, Prone Position/physiology, Radiography, Vertebral Artery/diagnostic imaging
in
Annals of Biomedical Engineering
volume
43
issue
6
pages
11 pages
publisher
Springer
external identifiers
  • pmid:26014360
  • scopus:84930766509
ISSN
1573-9686
DOI
10.1007/s10439-015-1340-5
language
English
LU publication?
no
id
69b8bc6b-4c08-4dc7-abcf-06038ee63e43
date added to LUP
2019-05-14 09:35:46
date last changed
2020-01-13 01:46:06
@article{69b8bc6b-4c08-4dc7-abcf-06038ee63e43,
  abstract     = {<p>The geometric and hemodynamic characteristics of the left and right vertebral arteries (LVA, RVA) of six healthy volunteers were investigated for the supine (S) and the prone position (P) a common sleeping posture with head rotation. MRI images were used to reconstruct the subject specific three-dimensional solid models of the LVA and RVA from the level of the carotid bifurcation to the vertebrobasilar junction (VJ). Geometric parameters such as cross sectional area ratio, curvature, tortuosity and branch angle were estimated. MR-PCA was used to obtain the blood flow waveforms for the two positions and computational fluid dynamics (CFD) were used to assess the flow field in terms of wall shear stress (WSS) relative residence times (RRT) and localized normalized helicity (LNH). Significant geometric changes but moderate flow changes were observed for both vertebral arteries with head rotation. The CFD results at the VJ show that head rotation causes changes in the WSS distribution, RRT and LNH. Further studies are warranted to assess the clinical significance of the results in terms of atherosclerosis development at the VJ and how the observed geometric changes may affect blood flow to the brain in healthy subjects and vertebral artery stenosis patients, and in terms of increased rapture susceptibility in vertebrobasilar aneurysm patients. </p>},
  author       = {Aristokleous, Nicolas and Seimenis, Ioannis and Georgiou, Georgios C and Nicolaides, Andrew and Anayiotos, Andreas S},
  issn         = {1573-9686},
  language     = {eng},
  number       = {6},
  pages        = {97--1287},
  publisher    = {Springer},
  series       = {Annals of Biomedical Engineering},
  title        = {The effect of head rotation on the geometry and hemodynamics of healthy vertebral arteries},
  url          = {http://dx.doi.org/10.1007/s10439-015-1340-5},
  doi          = {10.1007/s10439-015-1340-5},
  volume       = {43},
  year         = {2015},
}