A population-based study on serious inpatient bacterial infections in patients with chronic lymphocytic leukemia and their impact on survival
(2020) In European Journal of Haematology 105(5). p.547-554- Abstract
Objective: Infections in chronic lymphocytic leukemia (CLL) have been thoroughly investigated in the setting of clinical trials and single-center studies. However, large cohort studies on real-world data and studies on temporal trends are lacking. We performed a nationwide study on serious bacterial infections in CLL. Methods: Using high-quality Swedish government-based registries, 13 009 CLL patients diagnosed in 1982-2013 and their 49 380 matched controls were included. Results: Overall, CLL patients had an increased risk of serious inpatient bacterial infections with a hazard ratio (HR) 5.32 and 95% confidence interval (95% CI) 5.11-5.53, and the highest risk was observed for septicemia (HR 6.91, 95% CI 6.46-7.39) and lung infections... (More)
Objective: Infections in chronic lymphocytic leukemia (CLL) have been thoroughly investigated in the setting of clinical trials and single-center studies. However, large cohort studies on real-world data and studies on temporal trends are lacking. We performed a nationwide study on serious bacterial infections in CLL. Methods: Using high-quality Swedish government-based registries, 13 009 CLL patients diagnosed in 1982-2013 and their 49 380 matched controls were included. Results: Overall, CLL patients had an increased risk of serious inpatient bacterial infections with a hazard ratio (HR) 5.32 and 95% confidence interval (95% CI) 5.11-5.53, and the highest risk was observed for septicemia (HR 6.91, 95% CI 6.46-7.39) and lung infections (5.91, 5.64-6.18). The risk of serious inpatient bacterial infections decreased overtime with HR 0.87 (0.81-0.94) and HR 0.76 (0.70-0.82) in 1993-2002 and 2003-2013, respectively, compared to 1982-1992. CLL patients had an increased risk of death following a serious inpatient bacterial infection compared to matched CLL patients, and the risk was highest in the first 12 months after the infection (HR 5.48, 95% CI 5.11-5.90). Conclusion: We have, in this nationwide study, characterized the risk of serious bacterial infections in CLL patients and, importantly, depicted that the risk has decreased overtime.
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- author
- Steingrímsson, Vilhjálmur ; Gíslason, Gauti K. ; Aspelund, Thor ; Turesson, Ingemar LU ; Björkholm, Magnus ; Landgren, Ola and Kristinsson, Sigurdur Y.
- publishing date
- 2020-06-23
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- chronic lymphocytic leukemia, immunology and infectious diseases, lymphoproliferative diseases
- in
- European Journal of Haematology
- volume
- 105
- issue
- 5
- pages
- 547 - 554
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85087754278
- pmid:32575150
- ISSN
- 0902-4441
- DOI
- 10.1111/ejh.13477
- language
- English
- LU publication?
- no
- id
- 69d2eed4-c836-43bf-86a2-0822a4692a8b
- date added to LUP
- 2020-07-24 08:33:39
- date last changed
- 2024-04-03 11:53:40
@article{69d2eed4-c836-43bf-86a2-0822a4692a8b,
abstract = {{<p>Objective: Infections in chronic lymphocytic leukemia (CLL) have been thoroughly investigated in the setting of clinical trials and single-center studies. However, large cohort studies on real-world data and studies on temporal trends are lacking. We performed a nationwide study on serious bacterial infections in CLL. Methods: Using high-quality Swedish government-based registries, 13 009 CLL patients diagnosed in 1982-2013 and their 49 380 matched controls were included. Results: Overall, CLL patients had an increased risk of serious inpatient bacterial infections with a hazard ratio (HR) 5.32 and 95% confidence interval (95% CI) 5.11-5.53, and the highest risk was observed for septicemia (HR 6.91, 95% CI 6.46-7.39) and lung infections (5.91, 5.64-6.18). The risk of serious inpatient bacterial infections decreased overtime with HR 0.87 (0.81-0.94) and HR 0.76 (0.70-0.82) in 1993-2002 and 2003-2013, respectively, compared to 1982-1992. CLL patients had an increased risk of death following a serious inpatient bacterial infection compared to matched CLL patients, and the risk was highest in the first 12 months after the infection (HR 5.48, 95% CI 5.11-5.90). Conclusion: We have, in this nationwide study, characterized the risk of serious bacterial infections in CLL patients and, importantly, depicted that the risk has decreased overtime.</p>}},
author = {{Steingrímsson, Vilhjálmur and Gíslason, Gauti K. and Aspelund, Thor and Turesson, Ingemar and Björkholm, Magnus and Landgren, Ola and Kristinsson, Sigurdur Y.}},
issn = {{0902-4441}},
keywords = {{chronic lymphocytic leukemia; immunology and infectious diseases; lymphoproliferative diseases}},
language = {{eng}},
month = {{06}},
number = {{5}},
pages = {{547--554}},
publisher = {{Wiley-Blackwell}},
series = {{European Journal of Haematology}},
title = {{A population-based study on serious inpatient bacterial infections in patients with chronic lymphocytic leukemia and their impact on survival}},
url = {{http://dx.doi.org/10.1111/ejh.13477}},
doi = {{10.1111/ejh.13477}},
volume = {{105}},
year = {{2020}},
}