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Resveratrol promotes osteogenic differentiation of canine bone marrow mesenchymal stem cells through wnt/beta-catenin signaling pathway

Zhao, Xiao E. ; Yang, Zhenshan LU orcid ; Zhang, Hui ; Yao, Ge ; Liu, Jie ; Wei, Qiang and Ma, Baohua (2018) In Cellular Reprogramming 20(6). p.371-381
Abstract

Bone marrow mesenchymal stem cells (BMSCs) can transdifferentiate into different types of cells and may serve as a cell source for tissue engineering. Resveratrol has been shown to possess many benefits, including activation of osteogenesis. Furthermore, Wnt/β-catenin signaling has been known to promote osteogenic differentiation in many cells. In this study, we investigated the role of resveratrol in osteoblastic differentiation of canine BMSCs. Resveratrol treatment of canine BMSCs remarkably increased alkaline phosphatase activity and calcium nodules, inhibited the function of glycogen synthase kinase 3β, led to an increase in stabilization and nuclear accumulation of β-catenin, and upregulated expression of osteoblast-related marker... (More)

Bone marrow mesenchymal stem cells (BMSCs) can transdifferentiate into different types of cells and may serve as a cell source for tissue engineering. Resveratrol has been shown to possess many benefits, including activation of osteogenesis. Furthermore, Wnt/β-catenin signaling has been known to promote osteogenic differentiation in many cells. In this study, we investigated the role of resveratrol in osteoblastic differentiation of canine BMSCs. Resveratrol treatment of canine BMSCs remarkably increased alkaline phosphatase activity and calcium nodules, inhibited the function of glycogen synthase kinase 3β, led to an increase in stabilization and nuclear accumulation of β-catenin, and upregulated expression of osteoblast-related marker gene expression. In addition, resveratrol caused rapid activation of ERK1/2. Collectively, our results indicate that resveratrol promotes osteoblastic differentiation of canine BMSCs by activating the Wnt/β-catenin; ERK/MAPK signaling pathways are also involved in osteogenic differentiation of canine BMSCs.

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author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bone mesenchymal stem cells, Canine, Osteogenic differentiation, Resveratrol
in
Cellular Reprogramming
volume
20
issue
6
pages
11 pages
publisher
Mary Ann Liebert, Inc.
external identifiers
  • pmid:31251673
  • scopus:85058049964
ISSN
2152-4971
DOI
10.1089/cell.2018.0032
language
English
LU publication?
no
additional info
Funding Information: This study was supported by funds from the Natural Science Foundation of China, grant number: 31772818. Publisher Copyright: © 2018, Mary Ann Liebert, Inc., publishers 2018.
id
69ec56e2-d8bb-4306-b4c6-092236318613
date added to LUP
2024-02-28 14:59:22
date last changed
2024-03-30 09:29:15
@article{69ec56e2-d8bb-4306-b4c6-092236318613,
  abstract     = {{<p>Bone marrow mesenchymal stem cells (BMSCs) can transdifferentiate into different types of cells and may serve as a cell source for tissue engineering. Resveratrol has been shown to possess many benefits, including activation of osteogenesis. Furthermore, Wnt/β-catenin signaling has been known to promote osteogenic differentiation in many cells. In this study, we investigated the role of resveratrol in osteoblastic differentiation of canine BMSCs. Resveratrol treatment of canine BMSCs remarkably increased alkaline phosphatase activity and calcium nodules, inhibited the function of glycogen synthase kinase 3β, led to an increase in stabilization and nuclear accumulation of β-catenin, and upregulated expression of osteoblast-related marker gene expression. In addition, resveratrol caused rapid activation of ERK1/2. Collectively, our results indicate that resveratrol promotes osteoblastic differentiation of canine BMSCs by activating the Wnt/β-catenin; ERK/MAPK signaling pathways are also involved in osteogenic differentiation of canine BMSCs.</p>}},
  author       = {{Zhao, Xiao E. and Yang, Zhenshan and Zhang, Hui and Yao, Ge and Liu, Jie and Wei, Qiang and Ma, Baohua}},
  issn         = {{2152-4971}},
  keywords     = {{Bone mesenchymal stem cells; Canine; Osteogenic differentiation; Resveratrol}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{371--381}},
  publisher    = {{Mary Ann Liebert, Inc.}},
  series       = {{Cellular Reprogramming}},
  title        = {{Resveratrol promotes osteogenic differentiation of canine bone marrow mesenchymal stem cells through wnt/beta-catenin signaling pathway}},
  url          = {{http://dx.doi.org/10.1089/cell.2018.0032}},
  doi          = {{10.1089/cell.2018.0032}},
  volume       = {{20}},
  year         = {{2018}},
}