Clinical and epidemiological aspects of invasive Streptococcus pyogenes infections in Denmark during 2003 and 2004
(2008) In Journal of Clinical Microbiology 46(1). p.79-86- Abstract
- Active surveillance of invasive group A streptococcal (GAS) infections was conducted in Denmark during
2003 and 2004 as a part of the Strep-EURO initiative. The main objective was to improve understanding of the
epidemiology of invasive GAS disease in Denmark. During the 2 years, 278 cases were reported, corresponding
to a mean annual incidence of 2.6 cases per 100,000 inhabitants. The vast majority of isolates, 253 (91%), were
from blood, with the remaining 25 (9%) being from cerebrospinal fluid, joints, or other normally sterile sites.
The mean case fatality rate (CFR) was 20%, with the rate being higher in patients more than 70 years of age
(36.5%). For streptococcal toxic shock... (More) - Active surveillance of invasive group A streptococcal (GAS) infections was conducted in Denmark during
2003 and 2004 as a part of the Strep-EURO initiative. The main objective was to improve understanding of the
epidemiology of invasive GAS disease in Denmark. During the 2 years, 278 cases were reported, corresponding
to a mean annual incidence of 2.6 cases per 100,000 inhabitants. The vast majority of isolates, 253 (91%), were
from blood, with the remaining 25 (9%) being from cerebrospinal fluid, joints, or other normally sterile sites.
The mean case fatality rate (CFR) was 20%, with the rate being higher in patients more than 70 years of age
(36.5%). For streptococcal toxic shock syndrome (STSS) and necrotizing fasciitis the CFRs were 53% and 25%,
respectively. Out of 16 T types recorded, three predominated: T28 (23%), T1 (22%), and the cluster T3/13/B3264
(14%). Among 29 different emm types, emm28 and emm1 accounted for 51% of strains, followed by emm3 (11%),
emm89 (7%), and emm12 (5.5%). Low resistance rates were detected for macrolide-lincosamide-streptogramin
B (MLSB) antibiotics (3%) and tetracycline (8%); two isolates exhibited coresistance to tetracycline and
macrolides. Of nine pyrogenic exotoxin (superantigen) genes examined, speA and speC were identified in 58%
and 40% of the strains, respectively; either of the genes was present in all strains causing STSS. Most strains
harbored speG (99%). ssa was present in 14% of the isolates only. In Denmark, as in comparable countries, GAS
invasive disease shows a sustained, high endemicity, with involvement of both established and emerging
streptococcal emm and T types. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/951571
- author
- Luca, Bogdan LU ; Ekelund, Kim ; van der Linden, Mark ; Staum-Kaltoft, Margit ; Hammerum, Anette and Jasir, Aftab LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- streptococcal toxic shock syndrome, Streptococcus pyogenes, invasive group A streptococcal disease, antibiotic resistance, necrotising fasciitis
- in
- Journal of Clinical Microbiology
- volume
- 46
- issue
- 1
- pages
- 79 - 86
- publisher
- American Society for Microbiology
- external identifiers
-
- wos:000252392200009
- scopus:38149141425
- pmid:17959766
- ISSN
- 1098-660X
- DOI
- 10.1128/JCM.01626-07
- language
- English
- LU publication?
- yes
- id
- 69ed5c32-86c8-428e-973c-14c5fc8dfe59 (old id 951571)
- date added to LUP
- 2016-04-01 13:03:05
- date last changed
- 2023-01-03 20:36:16
@article{69ed5c32-86c8-428e-973c-14c5fc8dfe59,
abstract = {{Active surveillance of invasive group A streptococcal (GAS) infections was conducted in Denmark during<br/><br>
2003 and 2004 as a part of the Strep-EURO initiative. The main objective was to improve understanding of the<br/><br>
epidemiology of invasive GAS disease in Denmark. During the 2 years, 278 cases were reported, corresponding<br/><br>
to a mean annual incidence of 2.6 cases per 100,000 inhabitants. The vast majority of isolates, 253 (91%), were<br/><br>
from blood, with the remaining 25 (9%) being from cerebrospinal fluid, joints, or other normally sterile sites.<br/><br>
The mean case fatality rate (CFR) was 20%, with the rate being higher in patients more than 70 years of age<br/><br>
(36.5%). For streptococcal toxic shock syndrome (STSS) and necrotizing fasciitis the CFRs were 53% and 25%,<br/><br>
respectively. Out of 16 T types recorded, three predominated: T28 (23%), T1 (22%), and the cluster T3/13/B3264<br/><br>
(14%). Among 29 different emm types, emm28 and emm1 accounted for 51% of strains, followed by emm3 (11%),<br/><br>
emm89 (7%), and emm12 (5.5%). Low resistance rates were detected for macrolide-lincosamide-streptogramin<br/><br>
B (MLSB) antibiotics (3%) and tetracycline (8%); two isolates exhibited coresistance to tetracycline and<br/><br>
macrolides. Of nine pyrogenic exotoxin (superantigen) genes examined, speA and speC were identified in 58%<br/><br>
and 40% of the strains, respectively; either of the genes was present in all strains causing STSS. Most strains<br/><br>
harbored speG (99%). ssa was present in 14% of the isolates only. In Denmark, as in comparable countries, GAS<br/><br>
invasive disease shows a sustained, high endemicity, with involvement of both established and emerging<br/><br>
streptococcal emm and T types.}},
author = {{Luca, Bogdan and Ekelund, Kim and van der Linden, Mark and Staum-Kaltoft, Margit and Hammerum, Anette and Jasir, Aftab}},
issn = {{1098-660X}},
keywords = {{streptococcal toxic shock syndrome; Streptococcus pyogenes; invasive group A streptococcal disease; antibiotic resistance; necrotising fasciitis}},
language = {{eng}},
number = {{1}},
pages = {{79--86}},
publisher = {{American Society for Microbiology}},
series = {{Journal of Clinical Microbiology}},
title = {{Clinical and epidemiological aspects of invasive Streptococcus pyogenes infections in Denmark during 2003 and 2004}},
url = {{http://dx.doi.org/10.1128/JCM.01626-07}},
doi = {{10.1128/JCM.01626-07}},
volume = {{46}},
year = {{2008}},
}