Antibody mimicking polymers as chiral stationary phases in HPLC
(1996) In Analytical Chemistry 68(11). p.1948-1953- Abstract
- Antibody-mimicking synthetic polymers, selective for various optically active amino acid derivatives and peptides, were prepared by noncovalent molecular imprinting. A novel approach, in which the branched, trifunctional cross-linkers pentaerythritol triacrylate and 2,2-bis(hydroxymethyl)butanol trimethacrylate were copolymerized with methacrylic acid, is described. The polymers were subsequently applied as chiral stationary phases in high-performance liquid chromatography. They were superior to previously reported noncovalent molecularly imprinted polymers used for chiral separations in that they showed considerably higher load capacity, increased selectivity, and better resolving capability.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1516091
- author
- Kempe, Maria LU
- organization
- publishing date
- 1996
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Analytical Chemistry
- volume
- 68
- issue
- 11
- pages
- 1948 - 1953
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- scopus:0030153492
- ISSN
- 1520-6882
- DOI
- 10.1021/ac9512160
- language
- English
- LU publication?
- yes
- id
- 6a39efc1-d951-4edf-a59e-1efacfe1890b (old id 1516091)
- date added to LUP
- 2016-04-01 12:35:01
- date last changed
- 2022-03-21 06:21:46
@article{6a39efc1-d951-4edf-a59e-1efacfe1890b,
abstract = {{Antibody-mimicking synthetic polymers, selective for various optically active amino acid derivatives and peptides, were prepared by noncovalent molecular imprinting. A novel approach, in which the branched, trifunctional cross-linkers pentaerythritol triacrylate and 2,2-bis(hydroxymethyl)butanol trimethacrylate were copolymerized with methacrylic acid, is described. The polymers were subsequently applied as chiral stationary phases in high-performance liquid chromatography. They were superior to previously reported noncovalent molecularly imprinted polymers used for chiral separations in that they showed considerably higher load capacity, increased selectivity, and better resolving capability.}},
author = {{Kempe, Maria}},
issn = {{1520-6882}},
language = {{eng}},
number = {{11}},
pages = {{1948--1953}},
publisher = {{The American Chemical Society (ACS)}},
series = {{Analytical Chemistry}},
title = {{Antibody mimicking polymers as chiral stationary phases in HPLC}},
url = {{http://dx.doi.org/10.1021/ac9512160}},
doi = {{10.1021/ac9512160}},
volume = {{68}},
year = {{1996}},
}