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Impact of trigeminal and/or olfactory nerve stimulation on measures of inspiratory neural drive : Implications for breathlessness

Aucoin, Rachelle ; Lewthwaite, Hayley ; Ekström, Magnus LU orcid ; von Leupoldt, Andreas and Jensen, Dennis (2023) In Respiratory Physiology and Neurobiology 311.
Abstract

The perception of breathlessness is mechanistically linked to the awareness of increased inspiratory neural drive (IND). Stimulation of upper airway cold receptors on the trigeminal nerve (TGN) with TGN agonists such as menthol or cool air to the face/nose has been hypothesized to reduce breathlessness by decreasing IND. The aim of this systematic scoping review was to identify and summarize the results of studies in animals and humans reporting on the impact of TGN stimulation or blockade on measures of IND. Thirty-one studies were identified, including 19 in laboratory animals and 12 in human participants. Studies in laboratory animals consistently reported that as TGN activity increased, measures of IND decreased (e.g., phrenic nerve... (More)

The perception of breathlessness is mechanistically linked to the awareness of increased inspiratory neural drive (IND). Stimulation of upper airway cold receptors on the trigeminal nerve (TGN) with TGN agonists such as menthol or cool air to the face/nose has been hypothesized to reduce breathlessness by decreasing IND. The aim of this systematic scoping review was to identify and summarize the results of studies in animals and humans reporting on the impact of TGN stimulation or blockade on measures of IND. Thirty-one studies were identified, including 19 in laboratory animals and 12 in human participants. Studies in laboratory animals consistently reported that as TGN activity increased, measures of IND decreased (e.g., phrenic nerve activity). In humans, stimulation of the TGN with a stream of cool air to the face/nose decreased the sensitivity of the ventilatory chemoreflex response to hypercapnia. Otherwise, TGN stimulation with menthol or cool air to the face/note had no effect on measures of IND in humans. This review provides new insight into a potential neural mechanism of breathlessness relief with selected TGN agonists.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Breathlessness, Inspiratory neural drive, Nasal mucosa, Olfactory nerve, Trigeminal nerve, TRPM8 channels
in
Respiratory Physiology and Neurobiology
volume
311
article number
104035
publisher
Elsevier
external identifiers
  • scopus:85148085744
  • pmid:36792044
ISSN
1569-9048
DOI
10.1016/j.resp.2023.104035
language
English
LU publication?
yes
id
6a4e62da-5a8c-413a-864a-88bfcdec6da0
date added to LUP
2023-03-03 12:25:09
date last changed
2024-06-14 00:24:08
@article{6a4e62da-5a8c-413a-864a-88bfcdec6da0,
  abstract     = {{<p>The perception of breathlessness is mechanistically linked to the awareness of increased inspiratory neural drive (IND). Stimulation of upper airway cold receptors on the trigeminal nerve (TGN) with TGN agonists such as menthol or cool air to the face/nose has been hypothesized to reduce breathlessness by decreasing IND. The aim of this systematic scoping review was to identify and summarize the results of studies in animals and humans reporting on the impact of TGN stimulation or blockade on measures of IND. Thirty-one studies were identified, including 19 in laboratory animals and 12 in human participants. Studies in laboratory animals consistently reported that as TGN activity increased, measures of IND decreased (e.g., phrenic nerve activity). In humans, stimulation of the TGN with a stream of cool air to the face/nose decreased the sensitivity of the ventilatory chemoreflex response to hypercapnia. Otherwise, TGN stimulation with menthol or cool air to the face/note had no effect on measures of IND in humans. This review provides new insight into a potential neural mechanism of breathlessness relief with selected TGN agonists.</p>}},
  author       = {{Aucoin, Rachelle and Lewthwaite, Hayley and Ekström, Magnus and von Leupoldt, Andreas and Jensen, Dennis}},
  issn         = {{1569-9048}},
  keywords     = {{Breathlessness; Inspiratory neural drive; Nasal mucosa; Olfactory nerve; Trigeminal nerve; TRPM8 channels}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Respiratory Physiology and Neurobiology}},
  title        = {{Impact of trigeminal and/or olfactory nerve stimulation on measures of inspiratory neural drive : Implications for breathlessness}},
  url          = {{http://dx.doi.org/10.1016/j.resp.2023.104035}},
  doi          = {{10.1016/j.resp.2023.104035}},
  volume       = {{311}},
  year         = {{2023}},
}