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Testosterone deficiency and metabolic disturbances in men who fathered a child by use of donated spermatozoa

Elenkov, Angel LU ; Zarén, Peter LU orcid ; Sundell, Bianca ; Lundin, Lovisa and Giwercman, Aleksander LU (2022) In Scientific Reports 12. p.1-6
Abstract

Dose-response association between level of impairment of semen quality and risk of morbidity or premature death has been reported. Therefore, it can be presumed that men utilizing donated spermatozoa, i.e. patients with non-obstructive azoospermia, are at highest risk for adverse health outcomes. To evaluate the risks of prescription of medications for common metabolic disturbances and testosterone replacement therapy (TRT) among men who father children with donated spermatozoa-who presumably do it due to severe impairment of fertility. We used Swedish nationwide register data on all fathers who had a live-born child between 2007 and 2014 in order to compare men who fathered children with donated spermatozoa to the ones who became... (More)

Dose-response association between level of impairment of semen quality and risk of morbidity or premature death has been reported. Therefore, it can be presumed that men utilizing donated spermatozoa, i.e. patients with non-obstructive azoospermia, are at highest risk for adverse health outcomes. To evaluate the risks of prescription of medications for common metabolic disturbances and testosterone replacement therapy (TRT) among men who father children with donated spermatozoa-who presumably do it due to severe impairment of fertility. We used Swedish nationwide register data on all fathers who had a live-born child between 2007 and 2014 in order to compare men who fathered children with donated spermatozoa to the ones who became fathers by using own gametes. Cox regression analysis was used in order to estimate the post-conception incidence of prescription of medicines for hypertension (HT), diabetes (type 1 and 2), dyslipidaemia (DLE) or TRT. Starting the follow up at time of conception, models were adjusted for age, educational level, and previous cancer treatment. In total 410,119 childbirths were included in the analysis. Among them, for 390 fathers donated spermatozoa were utilized. Fathers to children conceived with donated spermatozoa had higher risk for having TRT prescribed (HR: 18.14; 95%CI: 11.71-28.10; p ≪ 0.001). Same was true for DLE (HR: 2.08; 95%CI: 1.27-3.39; p = 0.003) but not diabetes. Fathers to children conceived by use of donated spermatozoa are at significantly increased risk for testosterone treatment and dyslipidaemia, necessitating stringent follow up and inclusion in prevention programs.

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Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Azoospermia, Child, Female, Hormone Replacement Therapy, Humans, Male, Semen Analysis, Spermatozoa, Testosterone/therapeutic use
in
Scientific Reports
volume
12
article number
14458
pages
1 - 6
publisher
Nature Publishing Group
external identifiers
  • pmid:36002478
  • scopus:85136454287
ISSN
2045-2322
DOI
10.1038/s41598-022-17864-y
language
English
LU publication?
yes
additional info
© 2022. The Author(s).
id
6a5c4ae7-6fde-4e9a-93db-f03552488149
date added to LUP
2022-09-22 10:29:56
date last changed
2024-06-10 11:45:59
@article{6a5c4ae7-6fde-4e9a-93db-f03552488149,
  abstract     = {{<p>Dose-response association between level of impairment of semen quality and risk of morbidity or premature death has been reported. Therefore, it can be presumed that men utilizing donated spermatozoa, i.e. patients with non-obstructive azoospermia, are at highest risk for adverse health outcomes. To evaluate the risks of prescription of medications for common metabolic disturbances and testosterone replacement therapy (TRT) among men who father children with donated spermatozoa-who presumably do it due to severe impairment of fertility. We used Swedish nationwide register data on all fathers who had a live-born child between 2007 and 2014 in order to compare men who fathered children with donated spermatozoa to the ones who became fathers by using own gametes. Cox regression analysis was used in order to estimate the post-conception incidence of prescription of medicines for hypertension (HT), diabetes (type 1 and 2), dyslipidaemia (DLE) or TRT. Starting the follow up at time of conception, models were adjusted for age, educational level, and previous cancer treatment. In total 410,119 childbirths were included in the analysis. Among them, for 390 fathers donated spermatozoa were utilized. Fathers to children conceived with donated spermatozoa had higher risk for having TRT prescribed (HR: 18.14; 95%CI: 11.71-28.10; p ≪ 0.001). Same was true for DLE (HR: 2.08; 95%CI: 1.27-3.39; p = 0.003) but not diabetes. Fathers to children conceived by use of donated spermatozoa are at significantly increased risk for testosterone treatment and dyslipidaemia, necessitating stringent follow up and inclusion in prevention programs.</p>}},
  author       = {{Elenkov, Angel and Zarén, Peter and Sundell, Bianca and Lundin, Lovisa and Giwercman, Aleksander}},
  issn         = {{2045-2322}},
  keywords     = {{Azoospermia; Child; Female; Hormone Replacement Therapy; Humans; Male; Semen Analysis; Spermatozoa; Testosterone/therapeutic use}},
  language     = {{eng}},
  pages        = {{1--6}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Testosterone deficiency and metabolic disturbances in men who fathered a child by use of donated spermatozoa}},
  url          = {{http://dx.doi.org/10.1038/s41598-022-17864-y}},
  doi          = {{10.1038/s41598-022-17864-y}},
  volume       = {{12}},
  year         = {{2022}},
}