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Sperm DNA fragmentation index and cumulative live birth rate in a cohort of 2,713 couples undergoing assisted reproduction treatment

Vončina, Sladjana Malić ; Stenqvist, Amelie LU ; Bungum, Mona ; Schyman, Tommy and Giwercman, Aleksander LU (2021) In Fertility and Sterility 116(6). p.1483-1490
Abstract

Objective: To study how the choice of the first assisted reproductive technology treatment type affects the cumulative live birth rate (CLBR) in couples with high sperm DNA fragmentation index (DFI). Design: Longitudinal cohort study. Setting: University-affiliated fertility clinic. Patient(s): A total of 2,713 infertile couples who underwent assisted reproductive technology treatment between 2007 and 2017 were included in the study. All in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatments (up to three fresh treatments and all associated frozen-thawed embryo transfers) offered to the couples by the public health care system were included, in total 5,422 cycles. Intervention(s): None. Main Outcome Measure(s):... (More)

Objective: To study how the choice of the first assisted reproductive technology treatment type affects the cumulative live birth rate (CLBR) in couples with high sperm DNA fragmentation index (DFI). Design: Longitudinal cohort study. Setting: University-affiliated fertility clinic. Patient(s): A total of 2,713 infertile couples who underwent assisted reproductive technology treatment between 2007 and 2017 were included in the study. All in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatments (up to three fresh treatments and all associated frozen-thawed embryo transfers) offered to the couples by the public health care system were included, in total 5,422 cycles. Intervention(s): None. Main Outcome Measure(s): The primary outcome was the CLBR. The secondary outcomes were the fertilization rate and the miscarriage rate. The IVF and ICSI groups were defined according to the method applied in the first treatment cycle. Result(s): In the IVF group, the CLBR values were higher for couples with normal DFI compared with those for couples with high DFI (≥20%) (48.1% vs. 41.6% for conservative CLBR estimate and 55.6% vs. 51.4% for optimal CLBR estimate after adjustment for female age, respectively). No DFI-dependent difference was seen in the ICSI group. Conclusion(s): Our results demonstrated that a high DFI predicts a statistically significantly lower CLBR if IVF and not ICSI is applied in the first cycle of assisted reproduction.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
assisted reproduction, cumulative live birth rate, fertilization rate, sperm chromatin structure assay, Sperm DNA fragmentation
in
Fertility and Sterility
volume
116
issue
6
pages
1483 - 1490
publisher
Elsevier
external identifiers
  • scopus:85112036226
  • pmid:34376283
ISSN
0015-0282
DOI
10.1016/j.fertnstert.2021.06.049
language
English
LU publication?
yes
id
6a6f4aa3-aacf-4303-83e4-12dfe27918b3
date added to LUP
2021-09-02 17:07:05
date last changed
2024-09-22 23:35:08
@article{6a6f4aa3-aacf-4303-83e4-12dfe27918b3,
  abstract     = {{<p>Objective: To study how the choice of the first assisted reproductive technology treatment type affects the cumulative live birth rate (CLBR) in couples with high sperm DNA fragmentation index (DFI). Design: Longitudinal cohort study. Setting: University-affiliated fertility clinic. Patient(s): A total of 2,713 infertile couples who underwent assisted reproductive technology treatment between 2007 and 2017 were included in the study. All in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatments (up to three fresh treatments and all associated frozen-thawed embryo transfers) offered to the couples by the public health care system were included, in total 5,422 cycles. Intervention(s): None. Main Outcome Measure(s): The primary outcome was the CLBR. The secondary outcomes were the fertilization rate and the miscarriage rate. The IVF and ICSI groups were defined according to the method applied in the first treatment cycle. Result(s): In the IVF group, the CLBR values were higher for couples with normal DFI compared with those for couples with high DFI (≥20%) (48.1% vs. 41.6% for conservative CLBR estimate and 55.6% vs. 51.4% for optimal CLBR estimate after adjustment for female age, respectively). No DFI-dependent difference was seen in the ICSI group. Conclusion(s): Our results demonstrated that a high DFI predicts a statistically significantly lower CLBR if IVF and not ICSI is applied in the first cycle of assisted reproduction.</p>}},
  author       = {{Vončina, Sladjana Malić and Stenqvist, Amelie and Bungum, Mona and Schyman, Tommy and Giwercman, Aleksander}},
  issn         = {{0015-0282}},
  keywords     = {{assisted reproduction; cumulative live birth rate; fertilization rate; sperm chromatin structure assay; Sperm DNA fragmentation}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1483--1490}},
  publisher    = {{Elsevier}},
  series       = {{Fertility and Sterility}},
  title        = {{Sperm DNA fragmentation index and cumulative live birth rate in a cohort of 2,713 couples undergoing assisted reproduction treatment}},
  url          = {{http://dx.doi.org/10.1016/j.fertnstert.2021.06.049}},
  doi          = {{10.1016/j.fertnstert.2021.06.049}},
  volume       = {{116}},
  year         = {{2021}},
}