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A Comparison of Tumor Biology in Primary Ductal Carcinoma In Situ Recurring as Invasive Carcinoma versus a New In Situ.

Zhou, Wenjing ; Johansson, Christine ; Jirström, Karin LU orcid ; Ringberg, Anita LU ; Blomqvist, Carl ; Amini, Rose-Marie ; Fjallskog, Marie-Louise and Wärnberg, Fredrik (2013) In International Journal of Breast Cancer 2013.
Abstract
Introduction. About half of all new ipsilateral events after a primary ductal carcinoma in situ (DCIS) are invasive carcinoma. We studied tumor markers in the primary DCIS in relation to type of event (invasive versus in situ). Methods. Two hundred and sixty-six women with a primary DCIS from two source populations, all with a known ipsilateral event, were included. All new events were regarded as recurrences. Patient and primary tumor characteristics (estrogen receptor (ER), progesterone receptor (PR), HER2, EGFR, and Ki67) were evaluated. Logistic regression was used to calculate odd ratios and 95% confidence intervals in univariate and multivariate analyses. Results. One hundred and thirty-six of the recurrences were invasive carcinoma... (More)
Introduction. About half of all new ipsilateral events after a primary ductal carcinoma in situ (DCIS) are invasive carcinoma. We studied tumor markers in the primary DCIS in relation to type of event (invasive versus in situ). Methods. Two hundred and sixty-six women with a primary DCIS from two source populations, all with a known ipsilateral event, were included. All new events were regarded as recurrences. Patient and primary tumor characteristics (estrogen receptor (ER), progesterone receptor (PR), HER2, EGFR, and Ki67) were evaluated. Logistic regression was used to calculate odd ratios and 95% confidence intervals in univariate and multivariate analyses. Results. One hundred and thirty-six of the recurrences were invasive carcinoma and 130 were in situ. The recurrence was more often invasive if the primary DCIS was ER+ (OR 2.5, 95% CI 1.2-5.1). Primary DCIS being HER2+ (OR 0.5, 95% CI 0.3-0.9), EGFR+ (OR 0.4, 95% CI 0.2-0.9), and ER95-/HER2+ (OR 0.2, 95% CI 0.1-0.6) had a lower risk of a recurrence being invasive. Conclusions. In this study, comparing type of recurrence after a DCIS showed that the ER-/HER2+ tumors were related to a recurrence being a new DCIS. And surprisingly, tumors being ER+, HER2-, and EGFR- were related to a recurrence being invasive cancer. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
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in
International Journal of Breast Cancer
volume
2013
article number
582134
publisher
Hindawi Limited
external identifiers
  • pmid:24490077
  • pmid:24490077
ISSN
2090-3170
DOI
10.1155/2013/582134
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Surgery Research Unit (013242220)
id
6aa9980d-15c8-4c88-90f1-964f60f10751 (old id 4335797)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24490077?dopt=Abstract
date added to LUP
2016-04-01 14:01:56
date last changed
2024-01-29 02:53:29
@article{6aa9980d-15c8-4c88-90f1-964f60f10751,
  abstract     = {{Introduction. About half of all new ipsilateral events after a primary ductal carcinoma in situ (DCIS) are invasive carcinoma. We studied tumor markers in the primary DCIS in relation to type of event (invasive versus in situ). Methods. Two hundred and sixty-six women with a primary DCIS from two source populations, all with a known ipsilateral event, were included. All new events were regarded as recurrences. Patient and primary tumor characteristics (estrogen receptor (ER), progesterone receptor (PR), HER2, EGFR, and Ki67) were evaluated. Logistic regression was used to calculate odd ratios and 95% confidence intervals in univariate and multivariate analyses. Results. One hundred and thirty-six of the recurrences were invasive carcinoma and 130 were in situ. The recurrence was more often invasive if the primary DCIS was ER+ (OR 2.5, 95% CI 1.2-5.1). Primary DCIS being HER2+ (OR 0.5, 95% CI 0.3-0.9), EGFR+ (OR 0.4, 95% CI 0.2-0.9), and ER95-/HER2+ (OR 0.2, 95% CI 0.1-0.6) had a lower risk of a recurrence being invasive. Conclusions. In this study, comparing type of recurrence after a DCIS showed that the ER-/HER2+ tumors were related to a recurrence being a new DCIS. And surprisingly, tumors being ER+, HER2-, and EGFR- were related to a recurrence being invasive cancer.}},
  author       = {{Zhou, Wenjing and Johansson, Christine and Jirström, Karin and Ringberg, Anita and Blomqvist, Carl and Amini, Rose-Marie and Fjallskog, Marie-Louise and Wärnberg, Fredrik}},
  issn         = {{2090-3170}},
  language     = {{eng}},
  publisher    = {{Hindawi Limited}},
  series       = {{International Journal of Breast Cancer}},
  title        = {{A Comparison of Tumor Biology in Primary Ductal Carcinoma In Situ Recurring as Invasive Carcinoma versus a New In Situ.}},
  url          = {{https://lup.lub.lu.se/search/files/3732792/4862822.pdf}},
  doi          = {{10.1155/2013/582134}},
  volume       = {{2013}},
  year         = {{2013}},
}