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Quality of life among female childhood cancer survivors with and without premature ovarian insufficiency

Hjelmér, Ida LU ; Gustafsson Kylberg, Alicia ; Fridenborg, Anna ; Leijonhufvud, Irene LU ; Nyström, Anna LU ; Mörse, Helena LU ; Elfving, Maria LU ; Henic, Emir LU and Hannah, Nenonen LU (2023) In Journal of Cancer Survivorship 17(1). p.101-109
Abstract

Purpose: Due to an increase in survival, a growing population of childhood cancer survivors (CCS) is present. However, female CCS are at risk of developing premature ovarian insufficiency (POI) after cancer treatment. POI involves a decreased chance of conceiving and the increased infertility state has a large impact on affected individuals’ health and mental life. The objective of this study was to investigate health state and well-being among female CCS with and without POI and healthy controls (HC). Methods: Female CCS treated in southern Sweden between 1964 and 2008 were included. Each patient was matched with a HC. The final study population included 167 female CCS and 164 HC that were examined between October 2010 and January 2015... (More)

Purpose: Due to an increase in survival, a growing population of childhood cancer survivors (CCS) is present. However, female CCS are at risk of developing premature ovarian insufficiency (POI) after cancer treatment. POI involves a decreased chance of conceiving and the increased infertility state has a large impact on affected individuals’ health and mental life. The objective of this study was to investigate health state and well-being among female CCS with and without POI and healthy controls (HC). Methods: Female CCS treated in southern Sweden between 1964 and 2008 were included. Each patient was matched with a HC. The final study population included 167 female CCS and 164 HC that were examined between October 2010 and January 2015 at the Reproductive Medicine Centre at Skåne University Hospital in Malmö, Sweden. All participants, except for two HCs, answered an EQ-5D-3L questionnaire for measuring health state including a visual analogue scale (VAS) for estimating well-being. Results: There were 22 CCS with POI, none of the HC had POI. The mean health state differed among groups (unadjusted: P = 0.002; adjusted: P = 0.007). A difference in mean experienced well-being among groups was noted (unadjusted: P = 0.003; adjusted: P = 0.012). Lowest well-being was found in the CCS group with POI (P = 0.024). Conclusions: Female CCS have a significantly decreased health state and well-being. Female CCS with POI additionally have the lowest self-estimated well-being. Implications for Cancer Survivors: Female CCS with POI should be identified early in order to give them adequate information and support.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Childhood cancer survivors, Female, Premature ovarian insufficiency, Quality of life
in
Journal of Cancer Survivorship
volume
17
issue
1
pages
101 - 109
publisher
Springer
external identifiers
  • pmid:33469826
  • scopus:85099584101
ISSN
1932-2259
DOI
10.1007/s11764-021-00987-y
language
English
LU publication?
yes
id
6ab8d806-522f-4891-8ba8-a64f5b5a83f2
date added to LUP
2021-12-28 12:00:06
date last changed
2024-06-15 23:27:59
@article{6ab8d806-522f-4891-8ba8-a64f5b5a83f2,
  abstract     = {{<p>Purpose: Due to an increase in survival, a growing population of childhood cancer survivors (CCS) is present. However, female CCS are at risk of developing premature ovarian insufficiency (POI) after cancer treatment. POI involves a decreased chance of conceiving and the increased infertility state has a large impact on affected individuals’ health and mental life. The objective of this study was to investigate health state and well-being among female CCS with and without POI and healthy controls (HC). Methods: Female CCS treated in southern Sweden between 1964 and 2008 were included. Each patient was matched with a HC. The final study population included 167 female CCS and 164 HC that were examined between October 2010 and January 2015 at the Reproductive Medicine Centre at Skåne University Hospital in Malmö, Sweden. All participants, except for two HCs, answered an EQ-5D-3L questionnaire for measuring health state including a visual analogue scale (VAS) for estimating well-being. Results: There were 22 CCS with POI, none of the HC had POI. The mean health state differed among groups (unadjusted: P = 0.002; adjusted: P = 0.007). A difference in mean experienced well-being among groups was noted (unadjusted: P = 0.003; adjusted: P = 0.012). Lowest well-being was found in the CCS group with POI (P = 0.024). Conclusions: Female CCS have a significantly decreased health state and well-being. Female CCS with POI additionally have the lowest self-estimated well-being. Implications for Cancer Survivors: Female CCS with POI should be identified early in order to give them adequate information and support.</p>}},
  author       = {{Hjelmér, Ida and Gustafsson Kylberg, Alicia and Fridenborg, Anna and Leijonhufvud, Irene and Nyström, Anna and Mörse, Helena and Elfving, Maria and Henic, Emir and Hannah, Nenonen}},
  issn         = {{1932-2259}},
  keywords     = {{Childhood cancer survivors; Female; Premature ovarian insufficiency; Quality of life}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{101--109}},
  publisher    = {{Springer}},
  series       = {{Journal of Cancer Survivorship}},
  title        = {{Quality of life among female childhood cancer survivors with and without premature ovarian insufficiency}},
  url          = {{http://dx.doi.org/10.1007/s11764-021-00987-y}},
  doi          = {{10.1007/s11764-021-00987-y}},
  volume       = {{17}},
  year         = {{2023}},
}