131I-labelled anti-CD22 MAb (LL2) in patients with B-cell lymphomas failing chemotherapy. Treatment outcome, haematological toxicity and bone marrow absorbed dose estimates.
(2002) In Acta Oncologica 41(3). p.297-303- Abstract
- The experience with radioimmunotherapy in B-cell lymphomas using the rapidly internalizing antibody, anti-CD22 (LL2), is limited. In this study we investigated the efficacy and toxicity of 131I-labelled-LL2 for radioimmunotherapy in patients with B-cell lymphomas that failed one or two cytostatic regimens. Eleven patients were treated with one or repeated cycles of 131I-anti-CD22 antibody, 1330 MBq/m2 (36 mCi/m2). Six of the 11 treated patients demonstrated an objective response, three of them with complete remission. All follicular (3 patients) and transformed lymphomas (2 patients) responded compared to one of four diffuse large B-cell lymphomas. Two out of six responders exhibited event-free survival (EFS), which was comparable with or... (More)
- The experience with radioimmunotherapy in B-cell lymphomas using the rapidly internalizing antibody, anti-CD22 (LL2), is limited. In this study we investigated the efficacy and toxicity of 131I-labelled-LL2 for radioimmunotherapy in patients with B-cell lymphomas that failed one or two cytostatic regimens. Eleven patients were treated with one or repeated cycles of 131I-anti-CD22 antibody, 1330 MBq/m2 (36 mCi/m2). Six of the 11 treated patients demonstrated an objective response, three of them with complete remission. All follicular (3 patients) and transformed lymphomas (2 patients) responded compared to one of four diffuse large B-cell lymphomas. Two out of six responders exhibited event-free survival (EFS), which was comparable with or longer than the EFS following primary anthracycline-containing chemotherapy. Non-haematological toxicity was mild. Haematological toxicity was associated with pretreatment clinical characteristics but not with estimated absorbed bone marrow doses. Objective remission following treatment with 131I-anti-CD22 can be achieved in patients with various subtypes of B-cell lymphomas, failing standard chemotherapy. Follicular or transformed lymphomas seem particularly responsive. Haematological toxicity seems to be dependent on the functional status of the bone marrow before radioimmunotherapy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/110119
- author
- Lindén, Ola LU ; Tennvall, Jan LU ; Hindorf, Cecilia LU ; Cavallin-Ståhl, Eva LU ; Lindner, Karl-Johan ; Ohlsson, Tomas G LU ; Wingårdh, Karin LU and Strand, Sven-Erik LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Oncologica
- volume
- 41
- issue
- 3
- pages
- 297 - 303
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000177014000010
- pmid:12195750
- scopus:0035984437
- ISSN
- 1651-226X
- DOI
- 10.1080/02841860260088854
- language
- English
- LU publication?
- yes
- id
- 6abe27e2-a350-402e-9fbc-edf732400a85 (old id 110119)
- alternative location
- http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=12195750&ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
- date added to LUP
- 2016-04-01 16:44:38
- date last changed
- 2022-01-28 21:50:26
@article{6abe27e2-a350-402e-9fbc-edf732400a85,
abstract = {{The experience with radioimmunotherapy in B-cell lymphomas using the rapidly internalizing antibody, anti-CD22 (LL2), is limited. In this study we investigated the efficacy and toxicity of 131I-labelled-LL2 for radioimmunotherapy in patients with B-cell lymphomas that failed one or two cytostatic regimens. Eleven patients were treated with one or repeated cycles of 131I-anti-CD22 antibody, 1330 MBq/m2 (36 mCi/m2). Six of the 11 treated patients demonstrated an objective response, three of them with complete remission. All follicular (3 patients) and transformed lymphomas (2 patients) responded compared to one of four diffuse large B-cell lymphomas. Two out of six responders exhibited event-free survival (EFS), which was comparable with or longer than the EFS following primary anthracycline-containing chemotherapy. Non-haematological toxicity was mild. Haematological toxicity was associated with pretreatment clinical characteristics but not with estimated absorbed bone marrow doses. Objective remission following treatment with 131I-anti-CD22 can be achieved in patients with various subtypes of B-cell lymphomas, failing standard chemotherapy. Follicular or transformed lymphomas seem particularly responsive. Haematological toxicity seems to be dependent on the functional status of the bone marrow before radioimmunotherapy.}},
author = {{Lindén, Ola and Tennvall, Jan and Hindorf, Cecilia and Cavallin-Ståhl, Eva and Lindner, Karl-Johan and Ohlsson, Tomas G and Wingårdh, Karin and Strand, Sven-Erik}},
issn = {{1651-226X}},
language = {{eng}},
number = {{3}},
pages = {{297--303}},
publisher = {{Taylor & Francis}},
series = {{Acta Oncologica}},
title = {{131I-labelled anti-CD22 MAb (LL2) in patients with B-cell lymphomas failing chemotherapy. Treatment outcome, haematological toxicity and bone marrow absorbed dose estimates.}},
url = {{http://dx.doi.org/10.1080/02841860260088854}},
doi = {{10.1080/02841860260088854}},
volume = {{41}},
year = {{2002}},
}