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Shared genetic factors between osteoarthritis and cardiovascular disease may underlie common etiology

Magnusson, Karin LU ; Turkiewicz, Aleksandra LU ; Dell'Isola, Andrea LU and Englund, Martin LU orcid (2024) In Nature Communications 15(1).
Abstract

Osteoarthritis is one of the most common musculoskeletal diseases and increases the risk of severe cardiovascular disease, like heart attack and stroke. In some individuals, osteoarthritis and cardiovascular disease will co-occur. This co-occurrence might be due to shared risk factors, for example high age, lifestyle factors and/or a shared genetic liability for the two diseases. Here, we show that the correlation between osteoarthritis and cardiovascular disease can be explained by shared genetic factors, independent of high age and body weight, and also likely independent of lifestyle factors, like smoking and physical activity level. Findings suggest that genetic factors that are shared for osteoarthritis and cardiovascular disease... (More)

Osteoarthritis is one of the most common musculoskeletal diseases and increases the risk of severe cardiovascular disease, like heart attack and stroke. In some individuals, osteoarthritis and cardiovascular disease will co-occur. This co-occurrence might be due to shared risk factors, for example high age, lifestyle factors and/or a shared genetic liability for the two diseases. Here, we show that the correlation between osteoarthritis and cardiovascular disease can be explained by shared genetic factors, independent of high age and body weight, and also likely independent of lifestyle factors, like smoking and physical activity level. Findings suggest that genetic factors that are shared for osteoarthritis and cardiovascular disease may contribute to both diseases. Thus, the prevailing idea that osteoarthritis is predominantly a risk factor for cardiovascular disease is challenged. Our findings imply that the current diagnostic boundaries between these diseases may need to be re-evaluated.

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Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Humans, Osteoarthritis/genetics, Cardiovascular Diseases/genetics, Male, Female, Risk Factors, Middle Aged, Aged, Genetic Predisposition to Disease, Life Style, Smoking/adverse effects, Adult, Polymorphism, Single Nucleotide
in
Nature Communications
volume
15
issue
1
article number
9569
pages
10 pages
publisher
Nature Publishing Group
external identifiers
  • pmid:39500867
  • scopus:85208603447
ISSN
2041-1723
DOI
10.1038/s41467-024-53812-2
language
English
LU publication?
yes
additional info
© 2024. The Author(s).
id
6afad0ae-3644-4a92-9f8d-4236f7bea8fa
date added to LUP
2024-12-12 11:32:28
date last changed
2025-07-11 21:07:15
@article{6afad0ae-3644-4a92-9f8d-4236f7bea8fa,
  abstract     = {{<p>Osteoarthritis is one of the most common musculoskeletal diseases and increases the risk of severe cardiovascular disease, like heart attack and stroke. In some individuals, osteoarthritis and cardiovascular disease will co-occur. This co-occurrence might be due to shared risk factors, for example high age, lifestyle factors and/or a shared genetic liability for the two diseases. Here, we show that the correlation between osteoarthritis and cardiovascular disease can be explained by shared genetic factors, independent of high age and body weight, and also likely independent of lifestyle factors, like smoking and physical activity level. Findings suggest that genetic factors that are shared for osteoarthritis and cardiovascular disease may contribute to both diseases. Thus, the prevailing idea that osteoarthritis is predominantly a risk factor for cardiovascular disease is challenged. Our findings imply that the current diagnostic boundaries between these diseases may need to be re-evaluated.</p>}},
  author       = {{Magnusson, Karin and Turkiewicz, Aleksandra and Dell'Isola, Andrea and Englund, Martin}},
  issn         = {{2041-1723}},
  keywords     = {{Humans; Osteoarthritis/genetics; Cardiovascular Diseases/genetics; Male; Female; Risk Factors; Middle Aged; Aged; Genetic Predisposition to Disease; Life Style; Smoking/adverse effects; Adult; Polymorphism, Single Nucleotide}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{Shared genetic factors between osteoarthritis and cardiovascular disease may underlie common etiology}},
  url          = {{http://dx.doi.org/10.1038/s41467-024-53812-2}},
  doi          = {{10.1038/s41467-024-53812-2}},
  volume       = {{15}},
  year         = {{2024}},
}