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Effect of fasting hyperglycemia and insulin resistance on bone turnover markers in children aged 9–11 years

Bilinski, Wojciech J. ; Szternel, Lukasz ; Siodmiak, Joanna ; Krintus, Magdalena ; Paradowski, Przemyslaw T. ; Domagalski, Krzysztof and Sypniewska, Grazyna (2021) In Journal of Diabetes and its Complications 35(10).
Abstract

Aim: Impaired regulation of glucose metabolism in childhood adversely affects bone health. We assessed the effect of fasting hyperglycemia and insulin resistance on bone turnover markers in prepubertal children with normal glycemia (<100 mg/dL) and fasting hyperglycemia (100-125 mg/dL). Methods: Glucose, hemoglobin A1c, IGF-I (insulin-like growth factor I), iP1NP (N-terminal propeptide of type I procollagen), CTX-1 (C-terminal telopeptide of type I collagen) and insulin were measured. Bone turnover index (BTI) and HOMA-IR (homeostasis model assessment) were calculated. Results: Bone resorption marker (CTX) levels were decreased by 26.5% in boys with hyperglycemia, though only 7% in girls. Hyperglycemia had no effect on the bone... (More)

Aim: Impaired regulation of glucose metabolism in childhood adversely affects bone health. We assessed the effect of fasting hyperglycemia and insulin resistance on bone turnover markers in prepubertal children with normal glycemia (<100 mg/dL) and fasting hyperglycemia (100-125 mg/dL). Methods: Glucose, hemoglobin A1c, IGF-I (insulin-like growth factor I), iP1NP (N-terminal propeptide of type I procollagen), CTX-1 (C-terminal telopeptide of type I collagen) and insulin were measured. Bone turnover index (BTI) and HOMA-IR (homeostasis model assessment) were calculated. Results: Bone resorption marker (CTX) levels were decreased by 26.5% in boys with hyperglycemia, though only 7% in girls. Hyperglycemia had no effect on the bone formation marker iP1NP. IGF-1, the best predictor of bone marker variance accounted for 25% of iP1NP and 5% of CTX variance. Girls presented significantly higher BTI indicating the predominance of bone formation over resorption. Insulin resistance significantly decreased CTX. In girls, HOMA-IR and IGF-1 predicted 15% of CTX variance. Conslusions: Fasting hyperglycemia and insulin resistance in children impact bone turnover suppressing bone resorption. Hyperglycemia decreased resorption, particularly in boys, while suppression of resorption by insulin resistance was more pronounced in girls. We suggest that the progression of disturbances accompanying prediabetes, may interfere with bone modelling and be deleterious to bone quality in later life.

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author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bone turnover markers, Hyperglycemia, Insulin resistance, Osteoblasts, Osteoclasts
in
Journal of Diabetes and its Complications
volume
35
issue
10
article number
108000
publisher
Elsevier
external identifiers
  • scopus:85112137684
  • pmid:34384707
ISSN
1056-8727
DOI
10.1016/j.jdiacomp.2021.108000
language
English
LU publication?
no
id
6b0fec1c-4a01-4347-9975-997acbe78244
date added to LUP
2021-09-24 12:00:32
date last changed
2024-06-15 16:50:46
@article{6b0fec1c-4a01-4347-9975-997acbe78244,
  abstract     = {{<p>Aim: Impaired regulation of glucose metabolism in childhood adversely affects bone health. We assessed the effect of fasting hyperglycemia and insulin resistance on bone turnover markers in prepubertal children with normal glycemia (&lt;100 mg/dL) and fasting hyperglycemia (100-125 mg/dL). Methods: Glucose, hemoglobin A1c, IGF-I (insulin-like growth factor I), iP1NP (N-terminal propeptide of type I procollagen), CTX-1 (C-terminal telopeptide of type I collagen) and insulin were measured. Bone turnover index (BTI) and HOMA-IR (homeostasis model assessment) were calculated. Results: Bone resorption marker (CTX) levels were decreased by 26.5% in boys with hyperglycemia, though only 7% in girls. Hyperglycemia had no effect on the bone formation marker iP1NP. IGF-1, the best predictor of bone marker variance accounted for 25% of iP1NP and 5% of CTX variance. Girls presented significantly higher BTI indicating the predominance of bone formation over resorption. Insulin resistance significantly decreased CTX. In girls, HOMA-IR and IGF-1 predicted 15% of CTX variance. Conslusions: Fasting hyperglycemia and insulin resistance in children impact bone turnover suppressing bone resorption. Hyperglycemia decreased resorption, particularly in boys, while suppression of resorption by insulin resistance was more pronounced in girls. We suggest that the progression of disturbances accompanying prediabetes, may interfere with bone modelling and be deleterious to bone quality in later life.</p>}},
  author       = {{Bilinski, Wojciech J. and Szternel, Lukasz and Siodmiak, Joanna and Krintus, Magdalena and Paradowski, Przemyslaw T. and Domagalski, Krzysztof and Sypniewska, Grazyna}},
  issn         = {{1056-8727}},
  keywords     = {{Bone turnover markers; Hyperglycemia; Insulin resistance; Osteoblasts; Osteoclasts}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{10}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Diabetes and its Complications}},
  title        = {{Effect of fasting hyperglycemia and insulin resistance on bone turnover markers in children aged 9–11 years}},
  url          = {{http://dx.doi.org/10.1016/j.jdiacomp.2021.108000}},
  doi          = {{10.1016/j.jdiacomp.2021.108000}},
  volume       = {{35}},
  year         = {{2021}},
}